Guidance of ganciclovir therapy with pp65 antigenemia in cytomegalovirus-free recipients of livers from seropositive donors

Transplantation

Volumn 61, Issue 11, 1996, Pages 1659-1660

  Grossi, Paolo ^a,b   Kusne, Shimon ^a   Rinaldo, Charles ^c   St George, Kirsten ^c   Magnone, Mario ^a   Rakela, Jorge ^a   Fung, John ^a   Starzl, Thomas E ^a,d  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOMEGALOVIRUS ANTIBODY; GANCICLOVIR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PREDNISONE; TACROLIMUS; VIRUS ANTIGEN;

ANTIBODY TITER; ARTICLE; CYTOMEGALOVIRUS INFECTION; DONOR; HUMAN; IMMUNOFLUORESCENCE; IMMUNOSUPPRESSIVE TREATMENT; INTRAVENOUS DRUG ADMINISTRATION; LIVER; PRIORITY JOURNAL; RECIPIENT; RECURRENT DISEASE; VIRUS CULTURE; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CYTOMEGALOVIRUS INFECTIONS; GANCICLOVIR; HUMANS; LIVER TRANSPLANTATION; PHOSPHOPROTEINS; TISSUE DONORS; VIRAL MATRIX PROTEINS;

EID: 0029897418     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Rifkind D, Starzl TE, Marchioro TL, Waddell WR, Rolands DT Jr, Hill RB Jr. Transplantation pneumonia. JAMA 1964; 189: 808.
2. Rubin RH. Infection in the organ transplant recipient. In: Rubin RH, Young LS, eds. Clinical approach to infection in the compromised host. New York: Plenum, 1994: 629.
3. Martin M, Manez R, Linden P, et al. A prospective randomized trial comparing ganciclovir-high dose acyclovir to high dose acyclovir for prevention of cytomegalovirus disease in adult liver transplant recipients. Transplantation 1994; 58: 779.
4. Snydman DR, Werner BG, Dougherty NN, et al. Cytomegalovirus immunoglobulin prophylaxis in liver transplantation. Ann Intern Med 1993; 119: 984.
5. Rubin RH. Preemptive therapy in immunocompromised hosts. N Engl J Med 1991; 324: 1057.
6. The TH, Van Der Ploeg M, Van Der Berg AP, Vlieger AM, Van Der Giessen M, Van Son WJ. Direct detection of cytomegalovirus in peripheral blood leukocytes: a review of the antigenemia assay and polymerase chain reaction. Transplantation 1992; 54: 193.
7. Grossi P, Minoli L, Percivalle E, Irish W, Vigano M, Gerna G. Clinical and virological monitoring of human cytomegalovirus infection in 294 heart transplant recipients. Transplantation 1995; 59: 847.
8. Van der Bij W, Schirm J, Torensma R, Van Son WJ, Tegzess AM. Comparison between viremia and antigenemia for detection of cytomegalovirus in blood. J Clin Microbiol 1988; 26: 2531.
9. Revello MG, Percivalle E, Zavattoni M, Parea M, Grossi P, Gerna G. Detection of human cytomegalovirus immediate-early antigen in leukocyte as a marker of viremia in immunocompro-mised patients. J Med Virol 1989; 29: 88.
10. Starzl TE, Demetris AJ, Trucco M, et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993; 17: 1127.
11. Taylor-Wiedeman J, Sissons JGP, Borysiewicz LK, Sinclair JH. Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells. J Gen Virol 1991; 72: 2059.
12. Gerna G, Revello MG, Percivalle E, Morini F. Comparison of different immunostaining techniques and monoclonal antibodies to the lower matrix phosphoprotein (pp65) for optimal quantitation of human cytomegalovirus antigenemia. J Clin Microbiol 1992; 30: 1232.
13. Gerna G, Furione M, Baldanti F, Sarasini A. Comparative quantitation of human cytomegalovirus DNA in blood leukocytes and plasma of transplant and AIDS patients. J Clin Microbiol 1994; 32: 2709.
14. Gerna G, Zipeto D, Percivalle E, et al. Human cytomegalovirus infection of the major leukocyte subpopulations and evidence for initial viral replication in polymorphonuclear leukocytes from viremic patients. J Infect Dis 1992; 166: 1236.
15. Percivalle E, Revello MG, Vago L, Morini F, Gerna G. Circulating endothelial giant cells permissive for human cytomegalovirus (HCMV) are detected in disseminated HCMV infections with organ involvement. J Clin Invest 1993; 92: 663.