A randomized controlled study of the effect of bedside leucocyte depletion on the immunosuppressive effect of whole blood transfusion in patients undergoing elective colorectal surgery

British Journal of Surgery

Volumn 83, Issue 7, 1996, Pages 973-977

  Jensen, L S ^a   Hokland, M ^b   Nielsen, H J ^c  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CLINICAL TRIAL; COLORECTAL SURGERY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; WOUND INFECTION;

ADULT; AGED; AGED, 80 AND OVER; BLOOD TRANSFUSION; CD4-CD8 RATIO; COLONIC DISEASES; FEMALE; HUMANS; IMMUNE TOLERANCE; INTERLEUKIN-6; LEUKAPHERESIS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; RECEPTORS, INTERLEUKIN-2; RECTAL DISEASES; SURGICAL PROCEDURES, ELECTIVE; TIME FACTORS; TRANSPLANTATION IMMUNOLOGY;

EID: 0029896704     PISSN: 00071323     EISSN: None     Source Type: Journal    
DOI: 10.1002/bjs.1800830727     Document Type: Article

References (25)

1. Jensen LS, Andersen AJ, Christiansen PM et al. Post-operative infection and natural killer cell function following blood transfusion in patients undergoing elective colorectal surgery. Br J Surg 1992; 79: 513-16.
2. Nichols RL, Smith JW, Klein DB et al. Risk of infection after penetrating abdominal trauma. N Engl J Med 1984; 311: 1065-70.
3. Tartter PI. Blood transfusion and infectious complications following colorectal cancer surgery. Br J Surg 1988; 75: 789-92.
4. Houbiers JGA, Brand A, van de Watering LMG et al. Randomised controlled trial comparing transfusion of leucocyte-depleted or buffy-coat-depleted blood in surgery for colorectal cancer. Lancet 1994; 344: 573-8.
5. Vignali SA, Braga M, Radaelli G, DiCarlo V. Blood transfusion and postoperative infections in patients with cancer. Arch Surg 1993; 128: 115-19.
6. Miholic J, Hudec M, Domanig E et al. Risk factors for severe bacterial infections after valve replacement and aortocoronary bypass operations: analysis of 246 cases by logistic regression. Ann Thorac Surg 1985; 40: 224-8.
7. Triulzi DJ, Vanek K, Ryan DH, Blumberg N. A clinical and immunologic study of blood transfusion and postoperative bacterial infection in spinal surgery. Transfusion 1992; 32: 517-24.
8. Maetani S, Nishikawa T, Tobe TT, Hirakawa A. Role of blood transfusion in organ system failure following major abdominal surgery. Ann Surg 1986; 203: 275-81.
9. Agarwal N, Murphy JG, Cayten G, Stahl WM. Blood transfusion increases the risk of infection after trauma. Arch Surg 1993; 128: 171-7.
10. Nielsen HJ, Hammer JH, Moesgaard F, Kehlet H. Comparison of the effects of SAG-M and whole-blood transfusions on postoperative suppression of delayed hypersensitivity. Can J Surg 1991; 34: 146-50.
11. Kerman RH, Van Buren CT, Payne W et al. Influence of blood transfusion on immune responsiveness. Transplant Proc 1982; 14: 335-7.
12. Gascon P, Zoumbos NC, Young NS. Immunologic abnormalities in patients receiving multiple blood transfusions. Ann Intern Med 1984; 100: 173-7.
13. Kaplan J, Sarnaik S, Gitlin J, Lusher J. Diminished helper/ suppressor lymphocyte ratios and natural killer activity in recipients of repeated blood transfusions. Blood 1984; 64: 308-10.
14. Gafter Uzi, Kalechman Y, Sredni B. Induction of a subpopulation of suppressor cells by a single blood transfusion. Kidney Int 1992; 41: 143-8.
15. Fernandez LA, MacSween JM, You CK, Gorelick M. Immunologic changes after blood transfusion in patients undergoing vascular surgery. Am J Surg 1992; 163: 263-9.
16. Nielsen HJ, Hammer JH, Moesgaard F, Kehlet H. Ranitidine prevents postoperative transfusion-induced depression of delayed hypersensitivity. Surgery 1989; 105: 711-17.
17. Nielsen HJ. Detrimental effects of perioperative blood transfusion. Br J Surg 1995; 82: 582-7.
18. Nielsen HJ, Pedersen BK, Moesgaard F, Haahr PM, Kehlet H. Effect of ranitidine on postoperative suppression of natural killer cell activity and delayed hypersensitivity. Acta Chirurgica Scandinavica 1989; 155: 377-82.
19. Nielsen HJ, Mynster T, Jensen S, Hammer J, Nielsen H. Effect of ranitidine on soluble interleukin 2 receptors and CD8 molecules in surgical patients. Br J Surg 1994; 81: 1747-51.
20. Rasmussen LA, Nielsen HJ, Soørensen S et al. Ranitidine reduces postoperative interleukin-6 induced C-reactive protein synthesis. J Am Coll Surg 1995; 181: 138-44.
21. Salo M. Effects of anaesthesia and surgery on the immune response. Acta Anaesthesiol Scand 1992; 36: 201-20.
22. Cue JI, Peyton JC, Malangoni MA. Does blood transfusion or hemorrhagic shock induce immunosuppression? J Trauma 1992; 32: 613-17.
23. Blumberg N, Heal JM. Effects of transfusion on immune function. Cancer recurrence and infection. Arch Pathol Lab Med 1994; 118: 371-9.
24. Nielsen HJ, Edvardsen L, Vangsgaard K, Dybkjær E, Skov PS. Time-dependent histamine release from stored human blood products. Br J Surg 1996; 83: 257-62.
25. Persijn GG, Cohen B, Lansbergen Q, van Rood JJ Retrospective and prospective studies on the effect of blood transfusions in renal transplantation in The Netherlands. Transplantation 1979; 28: 396-401.