No evidence for mediation of ischemic preconditioning by alpha1-adrenergic signal transduction pathway or protein kinase C in the isolated rat heart

Cardiovascular Drugs and Therapy

Volumn 10, Issue 2, 1996, Pages 125-136

  Moolman, Johannes Albertus ^a   Genade, Sonia ^a   Tromp, Erna ^a   Lochner, Amanda ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

Alpha1 adrenergic signal transduction; Prazosin; Preconditioning; Protein kinase C

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; CHELERYTHRINE; LACTIC ACID; PHENYLEPHRINE; PRAZOSIN; PROTEIN KINASE C;

ANIMAL TISSUE; ARTICLE; DRUG ACTIVATION; HEART FUNCTION; ISCHEMIA; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ADRENERGIC ALPHA-ANTAGONISTS; ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; CARDIAC OUTPUT; CYCLIC AMP; ENERGY METABOLISM; HEART; INDOLES; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MALEIMIDES; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; PHENANTHRIDINES; PHOSPHATES; PRAZOSIN; PROTEIN KINASE C; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION;

EID: 0029896421     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00823590     Document Type: Article

References (35)

1. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-1136.
2. Liu GS, Thornton J, Van Winkle DM, Stanley AWH, Olsson RA, Downey JM. Protection against infarction afforded by preconditioning is mediated by A-1 adenosine receptors in rabbit heart. Circulation 1991;84:350-356.
3. Lasley RD, Anderson GM, Mentzer RM. Ischaemic and hypoxic preconditioning enhance postischaemic recovery of function in the rat heart. Cardiovasc Res 1993;27:565-570.
4. Cave AC, Colis CS, Downey JM, Hearse D. Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart. Cardiovasc Res 1993;27:663-668.
5. 1 receptor activation. Basic Res Cardiol 1993; 88:576-593.
6. Banerjee A, Locke-Winter C, Rogers K, et al. Preconditioning against myocardial dysfunction after ischaemia and reperfusion by an alpha-1 adrenergic mechanism. Circ Res 1993;73:656-670.
7. Bankwala Z, Hale SL, Kloner RA. Alpha adrenoreceptor stimulation with exogenous norepinephrine or release of endogenous norepinephrine mimics ischemic preconditioning (abstract). Circulation 1994;90:1023-1028.
8. Hu K, Nattel A. Signal transduction underlying ischemic preconditioning in rat hearts (abstract). Circulation 1994; 90:1-108.
9. Tsuchida A, Liu Y, Cohen MV, Downey JM. Alpha-1 adrenergic agonists precondition rabbit ischemic myocardium independent of adenosine by direct activation of protein kinase C. Circ Res 1994;75:576-585.
10. Thornton JD, Daly JF, Cohen MV, Yang X, Downey JM. Catecholamines can induce adenosine receptor-mediated protection of the myocardium but do not participate in ischemic preconditioning in the rabbit. Circ Res 1993;73: 649-655.
11. Toombs CF, Wiltse AL, Shebuski RJ. Ischemic preconditioning fails to limit infarct size in reserpinized rabbit myocardium. Circulation 1993;88[part1]:2351-2358.
12. Cave AC, Apstein CS. Inhibition of protein kinase C abolishes preconditioning against contractile dysfunction in the isolated perfused rat heart (abstract). Circulation 1994;90: I-208.
13. Ytrehus K, Liu Y, Downey JM. Preconditioning protects ischemic rabbit heart by protein kinase C activation. Am J Physiol 1994;286:H1145-H1152.
14. Armstrong S, Downey JM, Ganote CE. Preconditioning of isolated rabbit cardiomyocytes: Induction by metabolic stress and blockade by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor. Cardiovasc Res 1994;28:72-77.
15. Speechly-Dick ME, Mocanu MM, Yellon DM. Protein kinase C. Its role in ischemic preconditioning in the rat. Circ Res 1994;75:586-590.
16. Mitchell MB, Meng X, Ao L, Brown JM, Harken AH, Banerjee A. Preconditioning of isolated rat heart is mediated by protein kinase C. Cire Res 1995;76:73-81.
17. Weselcouch E, Baird AJ, Sleph PG, Dzwonckzyk S, Murray HN, Grover GJ. Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart. Cardiovasc Res 1995;29:126-132.
18. Ardell JL, Yang X-M, Thornton JD, Swafford A, Cohen MV, Downey JM. Depletion of norepinephrine by chronic surgical sympathectomy does not block preconditioning from ischemic preconditioning (abstract). Circulation 1994; 90:I-108.
19. Kolocassides K, Galiñanes M. The specific protein kinase C inhibitor chelerythrine fails to inhibit ischemic preconditioning in the rat heart. Circulation 1994;90:I-208.
20. 1 adrenoreceptor stimulation (abstract). Circulation 1993;88(Suppl):1-43.
21. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructral damage during a sustained ischemic episode. Circ Res 1990;66:913-931.
22. Moolman JA, Genade S, Winterbach R, Harper IS, Williams K, Lochner A. Preconditioning with a single short episode of global ischemia in the isolated rat heart: Effect on structure, mechanical function, and energy metabolism for various durations of sustained global ischemia. Cardiovasc Drugs Ther 1995;9:103-115.
23. Kannengiesser GJ, Opie LH, Van der Werff TJ. Impaired cardiac work and oxygen uptake after reperfusion of regionally ischemic myocardium. J Mol Cell Cardiol 1979;11: 197-207.
24. Lampbrecht W, Trautschold I. ATP: Determination with hexokinase and glucose-6-phosphate dehydrogenase. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis, 2nd English ed. New York: Academic Press, 1974:2105.
25. Victor T, Bester AJ, Lochner A. A sensitive and rapid method for separating adenine nucleotides and creatine phosphate by ion-pair-reversed-phase high-performance liquid chromatography. J Chromatogr 1987;389:339-344.
26. Hattingh, PW. The Role of β-adrenergic Blockers and Calcium Antagonists on the Inotropy of the Isolated Rat Heart After Cardioplegic Arrest. PhD thesis, University of Stellenboch, Tygerberg, South Africa, 1991.
27. Nayler WG, Gordon M, Stephens DJ, Sturrock WJ. The protective effect of prazosin on the ischaemic and reperfused myocardium. J Mol Cell Cardiol 1985;17:685-699.
28. Endoh M, Brodde OE, Schumann HJ. Relationship between the level of cAMP and the contactile force under the stimulation of alpha- and beta-adrenoreceptors by phenylephrine in the isolated rabbit papillary muscle. Naunyn Schmiedebergs Arch Pharmacol 1976;295:109-1015.
29. Schömig A, Dart AM, Dietz R, Mayer E, Kübler W. Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release. Circ Res 1984;55:689-701.
30. Vogt A, Barancik M, Weihrauch D, Arras M, Podzuweit T, Schaper W. Protein kinase C inhibitors reduce infarct size in pig hearts in vivo. Circulation 1994;90:I-647
31. Kolocassides KG, Galiñanes M, Hearse DJ. The protein kinase C inhibitor polymyxin B blocks the functional protection of preconditioning but not the acceleration of ischaemic contracture. J Mol Cell Cardiol 1995;27:A155.
32. Gillman AG, Goodman LS, Rail TW, Murad F. The Pharmacological Basis of Therapeutics, 7th ed. New York: Mac-Millan, 1985:1191-1192.
33. Weinbrenner CE, Simonis G, Marquetant R, Strasser RH. Selective regulation of calcium-dependent and calcium independent subtypes of protein-kinase C in acute and prolonged myocardial ischemia (abstract). Circulation 1993; 88(Suppl):I-101.
34. 1-receptor-independent activation of protein kinase C in acute myocardial ischaemia. Mechanisms for sensitization of the adenyl cyclase system. Circ Res 1992;70:1304-1312.
35. 1-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem 1993;268:15374-15380.