Internally standardized simultaneous assay of gallopamil enantiomers in human plasma by means of high performance liquid chromatography

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 18, Issue 4, 1996, Pages 279-285

  Kern, R ^a  

^a Biochemistry ^*  (Germany)

Author keywords

Ca2+ antagonist; Chiral assay; Enantiomers; Gallopamil; HPLC; Human plasma

Indexed keywords

GALLOPAMIL; LU 30029; LU 33923; LU 33924; UNCLASSIFIED DRUG;

ARTICLE; DRUG DETERMINATION; DRUG ISOLATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PLASMA; RACEMIC MIXTURE;

1-PROPANOL; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GALLOPAMIL; HEXANES; HUMANS; HYDROGEN-ION CONCENTRATION; PREDICTIVE VALUE OF TESTS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SODIUM HYDROXIDE; STEREOISOMERISM;

EID: 0029896077     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Bender, F., Meesmann, W. Therapie mit Gallopamil. Steinkopf Verlag: Darmstadt 1987.
2. Ariens, E.J. Stereochemistry, a basis fur sophisticated nonsense in pharmacokinetics and clinical pharmacology. Eur J Clin Pharmacol 1984, 26: 663-8.
3. Ariens, E.J., Mohr, K. Stereochemische Irrwege in der Pharmakotherapie. Deutsch Med Wochen 1985, 100 (45): 1741.
4. Walle, T., Walle, U.K. Pharmacokinetic parameters obtained with racemates. Trends Pharmacol Sci 1986, 4: 155-8.
5. Weymann, J., Bühler, V., Hege, H.G. et al. Metabolism of the calcium antagonist gallopamil in man. Arzneim-Forsch/Drug Res 1989, 39 (5): 605-7.