Suppression of channel conductance by diacetyl monoxime in guinea pig and embryonic chick cardiomyocytes

Acta Pharmacologica Sinica

Volumn 17, Issue 3, 1996, Pages 201-206

  Sada, Hideaki ^a   Ban, Takashi ^a   Sperelakis, Nicholas ^b  

^a YAMAGUCHI UNIVERSITY   (Japan)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

calcium channels; cultured cells; diacetyl monoxime; myocardium; oximes; patch clamp techniques; potassium channels; sodium channels

Indexed keywords

CALCIUM CHANNEL; DIACETYL OXIME; ION CHANNEL; PHOSPHATASE; POTASSIUM CHANNEL; SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHICKEN; CONTROLLED STUDY; DEPHOSPHORYLATION; EMBRYO; GUINEA PIG; HEART MUSCLE CELL; ION CONDUCTANCE; NONHUMAN; POTASSIUM CURRENT; SODIUM CURRENT; VOLTAGE CLAMP;

ANIMALS; CALCIUM CHANNELS; CELLS, CULTURED; CHICK EMBRYO; CHOLINESTERASE REACTIVATORS; DIACETYL; GUINEA PIGS; ION CHANNELS; MEMBRANE POTENTIALS; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SODIUM CHANNELS;

EID: 0029895975     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Sellin LC, McArdle JJ. Multiple effects of 2,3-butanedione monoxime. Pharmacol Toxicol 1994; 74: 305-13.
2. Huang G-J, McArdle JJ. Novel suppression of an L-type calcium channel in neurones of murine dorsal root ganglia by 2,3-butanedione monoxime. J Physiol (Lond) 1992; 447: 257-74.
3. Chapman RA. The effect of oximes on the dihydropyridine sensitive Ca current of isolated guinea-pig ventricular myocytes. Pflügers Arch 1993; 422: 325-31.
4. Sperelakis N. Regulation of calcium slow channels of hearts by cyclic nucleotides and effects of ischemia. Adv Pharmacol 1994; 31: 1-24.
5. Matsuda JJ, Lee H, Shibata EF. Enhancement of rabbit cardiac sodium channels by β-adrenergic stimulation. Circ Res 1992; 70: 199-207.
6. + channels in endothelial cells. Circ Res 1993; 73: 492-5.
7. Sada H, Kojima M, Sperelakis N. Fast inward current properties of voltage-clamped ventricular cells of embryonic chick heart. Am J Physiol 1988; 255: H541-53.
8. Mitra R, Morad M. A uniform enzymatic method for dissociation of myocytes from hearts and stomachs of vertebrates. Am J Physiol 1985; 249: H1056-60.
9. Wiggins JR, Reiser J, Fitzpatrick DF, Bergey JL. Inotropic actions of diacetyl monoxime in cat ventricular muscle. J Pharmacol Exp Ther 1980; 212: 217-24.
10. Bergey JL, Reiser J, Wiggins JR, Freeman AR. Oximers: 'enzymatic' slow channel antagonists in canine cardiac Purkinje fibers? Eur J pharmacol 1981; 71: 307-19.
11. Li T, Sperelakis N, Teneick RE, Solaro RJ. Effects of diacetyl monoxime on cardiac excitation-contraction coupling. J Pharmacol Exp Ther 1985; 232: 688-95.
12. Sada H, Sada S, Sperelakis N. Effects of diacetyl monoxime (DAM) on slow and fast action potentials of young and old embryonic chick hearts and rabbit hearts. Eur J Pharmacol 1985; 112: 145-52.
13. Mömer SEJN, Wohlfart B. The action of 2, 3-butanedione-monoxime on the inotropic state in guinea-pig myocardium. Acta Physiol Scand 1991; 142: 211-9.
14. Coulombe A, Lefevre IA, Deroubaix E, Thuringer D, Coraboeuf E. Effect of 2, 3-butanedione 2-monoxime on slow inward and transient outward currents in rat ventricular myocytes. J Mol Cell Cardiol 1990; 22: 921-32.