Increased radiosensitivity by a combination of 9-cis-retinoic acid and interferon-γ in breast cancer cells

Gynecologic Oncology

Volumn 61, Issue 3, 1996, Pages 387-394

  Windbichler, Gudrun H ^a   Hensler, Emil ^a   Widschwendter, Martin ^a   Posch, Andrea ^a   Daxenbichler, Günter ^a   Fritsch, Esther ^a   Marth, Christian ^a  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; ALPHA INTERFERON; BIOLOGICAL RESPONSE MODIFIER; ISOTRETINOIN; RECOMBINANT GAMMA INTERFERON;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG POTENTIATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; UTERINE CERVIX CARCINOMA;

EID: 0029895197     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.1996.0162     Document Type: Article

References (46)

1. Lippman, S. M., Parkinson, D. R., Itri, L. M., Weber, R. S., Schantz, S. P., Ota, D. M., Schusterman, M. A., Krakoff, I. H., Gutterman, J. U., and Hong, W. K. 13-cis-Retinoic acid and interferon-α 2a: Effective combination therapy for advanced squamous cell carcinoma of the skin, J. Natl. Cancer Inst. 84, 235-241 (1992).
2. Lippman, S. M., Kavanagh, J. J., Paredes-Espinoza, M., Delgadillo-Madrueño, F., Paredes-Casillas, P., Hong, W. K., Holdener, E. E., and Krakoff, I. H. 13-cis-Retinoic acid plus interferon-α 2a: Highly active systemic therapy for squamous cell carcinoma of the cervix, J. Natl. Cancer Inst. 84, 241-245 (1992).
3. Lippman, S. M., Kavanagh, J. J., Paredes-Espinoza, M., Delgadillo-Madrueño, F., Paredes-Casillas, P., Hong, W. K., Massimini, G., Holdener, E. E., and Krakoff, I. H. 13-cis-Retinoic acid plus interferon-α 2a in locally advanced squamous cell carcinoma of the cervix, J. Natl. Cancer Inst. 85, 499-500 (1993).
4. Bollag, W., and Holdener, E. E. Retinoids in cancer prevention and therapy, Ann. Oncol. 3, 513-526 (1992).
5. Smith, M. A., Parkinson, D. R., Cheson, B. D., and Friedman, M. A. Retinoids in cancer therapy, J. Clin. Oncol. 10, 839-864 (1992).
6. Baron, S., Tyring, S. K., Fleischmann, W. R., Coppenhaver, D. H., Niesel, D. W., Klimpel, G. R., Stanton, G. J., and Hughes, T. K. The interferons: Mechanisms of action and clinical applications, JAMA 266, 1375-1383 (1991).
7. Aguet, M., Dembritz, Z., and Merlin, G. Molecular cloning and expression of the human interferon-γ receptor, Cell 55, 273-280 (1988).
8. Petkovich, M. Regulation of gene expression by vitamin A: The role of nuclear retinoic acid receptors, Annu. Rev. Nutr. 12, 443-471 (1992).
9. Wuarin, L., Verity, M. A., and Sidell, N. Effects of interferon-gamma and its interaction with retinoic acid on human neuroblastoma differentiation, Int. J. Cancer 48, 136-141 (1991).
10. Cornaglia-Ferraris, P., Mariottini, G. L., and Ponzoni, M. γ-Interferon and retinoic acid synergize in inhibiting the growth of human neuroblastoma cells in nude mice, Cancer Lett. 61, 215-220 (1991).
11. Hemmi, H., and Breitman, T. R. Combinations of recombinant human interferons and retinoic acid synergistically induce differentiation of the human promyelocytic leukemia cell line HL-60, Blood 69, 501-507 (1987).
12. Grant, S., Bhalla, K., Weinstein, I. B., Pestka, S., Mileno, M. D., and Fisher, P. B. Recombinant human interferon sensitized resistant myeloid leukemic cells to induction of terminal differentiation, Biochem. Biophys. Res. Commun. 130, 379-388 (1985).
13. Peck, R., and Bollag, W. Potentiation of retinoid-induced differentiation of HL-60 and U937 cell lines by cytokines, Eur. J. Cancer 27, 53-57 (1991).
14. Bollag, W., Majewski, S., and Jablonska, S. Cancer combination chemotherapy with retinoids: Experimental rationale, Leukemia 8, 1453-1457 (1994).
15. Fontana, J. A. Interaction of retinoids and tamoxifen on the inhibition of human mammary carcinoma cell proliferation, Exp. Cell Biol. 55, 136-144 (1987).
16. Marth, C., Böck, G., and Daxenbichler, G. Effect of 4-hydroxyphenyl-retinamide and retinoic acid on proliferation and cell cycle of cultured human breast cancer cells, J. Natl. Cancer Inst. 75, 871-875 (1985).
17. Lotan, R. Suppression of squamous cell carcinoma growth and differentiation by retinoids, Cancer Res. 54(Suppl.), 1987s-1990s (1994).
18. Toma, S., Monteghirfo, S., Tasso, P., Nicolo, G., Spadini, N., Palumbo, R., and Molina, F. Antiproliferative and synergistic effect of interferon alpha-2a, retinoids and their association in established human cancer cell lines, Cancer Lett. 82, 209-216 (1994).
19. Marth, C., Daxenbichler, G., and Dapunt, O. Synergistic antiproliferative effect of human recombinant interferons and retinoic acid in cultured breast cancer cells, J. Natl. Cancer Inst. 77, 1197-1202 (1986).
20. Marth, C., Zech, J., Böck, G., Mayer, I., and Daxenbichler, G. Effects of retinoids and interferon-gamma on cultured breast cancer cells in comparison with tumor necrosis factor alpha, Int. J. Cancer 40, 840-845 (1987).
21. Lippman, S. M., Glisson, B. S., Kavanagh, J. J., Lotan, R., Hong, W. K., Paredes-Espinoza, M., Hittelman, W. N., Holdener, E. E., and Krakoff, I. H. Retinoic acid and interferon combination studies in human cancer, Eur. J. Cancer 29A(Suppl 5), 9-13 (1993).
22. Widschwendter, M., Daxenbichler, G., Dapunt, O., and Marth, C. Effects of retinoic acid and γ-interferon on expression of retinoic acid receptor and cellular retinoic acid-binding protein in breast cancer cells, Cancer Res. 55, 2135-2139 (1995).
23. Marth, C., Widschwendter, M., and Daxenbichler, G. Mechanism of synergistic action of all-trans-or 9-cis-retinoic acid and interferons in breast cancer cells, J. Steroid Biochem. Mol. Biol. 47, 123-126 (1993).
24. Sachs, L. Angewandte Statistik, Springer-Verlag, Berlin/Heidelberg/ New York (1992).
25. Fertil, B., Dertinger, H., Courdi, A., and Malaise, E. P. Mean inactivation dose: A useful concept for intercomparison of human cell survival curves, Radiat. Res. 99, 73-84 (1984).
26. Angioli, R., Sevin, B. U., Perras, J. P., Untch, M., Koechli, O. R., Nguyen, H. N., Steren, A., Schwade, J. G., Villani, C., and Averette, H. E. In vitro potentiation of radiation cytotoxicity by recombinant interferons in cervical cancer cell lines, Cancer 71, 3717-3725 (1993).
27. 2-M phase of the cell cycle, Cancer Res. 47, 4338-4341 (1987).
28. Rutz, H. P., and Little, J. B. Modification of radiosensitivity and recovery from X-ray damage in vitro by retinoic acid, Int. J. Radiat. Oncol. Biol. Phys. 16, 1285-1288 (1989).
29. Hoffmann, W., Schiller, U., Rodemann, H. P., and Bamberg, M. Vitamin A in cancer treatment: Impact of clinical and preclinical data on radio-oncology, Strahlenther. Onkol. 171, 106-112 (1995).
30. Kardamakis, D., Gillies, N. E., Souhami, R. L., and Bewerley, P. C. Recombinant human interferon alpha-2b enhances the radiosensitivity of small cell lung cancer in vitro, Anticancer Res. 9, 1041-1044 (1989).
31. Hong, W. K., Lippman, S. M., Itri, L. M., Karp, D. D., Lee, J. S., Byers, R. M., Schantz, S. P., Kramer, A. M., Lotan, R., Peters, L. J., Dimery, I. W., Brown, B. W., and Goepfert, H. Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck, N. Engl. J. Med. 323, 795-801 (1990).
32. Anzano, M. A., Byers, S. W., Smith, J. M., Peer, C. W., Mullen, L. T., Brown, C. C., Roberts, A. B., and Sporn, M. B. Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen, Cancer Res. 54, 4614-4617 (1994).
33. Lee, J. S., Newman, R. A., Lippman, S. M., Huber, M. H., Minor, T., Raber, M. N., Krakoff, I. H., and Hong, W. K. Phase I evaluation of all-trans-retinoic acid in adults with solid tumors, J. Clin. Oncol. 11, 959-966 (1993).
34. Quesada, J. R., Reuben, J., Manning, J. T., Hersh, E. M., and Gutterman, J. U. Alpha interferon for induction of remission in hairy cell leukemia, N. Engl. J. Med. 310, 15-18 (1984).
35. Vokes, E. E. The promise of biochemical modulation in combined modality therapy, Semin. Oncol. 21(Suppl. 14), 29-33 (1994).
36. McDonald, S., Chang, A. Y., Rubin, P., Wallenberg, J., Kim, I. S., Sobel, S., Smith, J., Keng, P., and Muhs, A. Combined betaseron R (recombinant human interferon beta) and radiation for inoperable non-small cell lung cancer, Int. J. Radiat. Oncol. Biol. Phys. 27, 613-619 (1993).
37. Torrisi, J., Berg, C., Harter, K., Lvovsky, E., Yeung, K., Wolley, P., Bonnem, E., and Dritschilo, A. Phase I combined modality clinical trial of alpha-2-interferon and radiotherapy, Int. J. Radiat. Oncol. Biol. Phys. 12, 1453-1456 (1986).
38. Maasilta, P., Holsti, L. R., Halme, M., Kivisaari, L., Cantell, K., and Mattson, K. Natural alpha-interferon in combination with hyperfractionated radiotherapy in the treatment of non-small cell lung cancer, Int. J. Radiat. Oncol. Biol. Phys. 23, 863-868 (1992).
39. Shaw, E. G., Deming, R. L., Creagan, E. T., Nair, S., Su, J. Q., Levitt, R., Steen, P. D., Wiesenfeld, M., and Mailliard, J. A. Pilot study of human recombinant interferon gamma and accelerated hyperfractionated thoracic radiation therapy in patients with unresectable stage IIIA/ B nonsmall cell lung cancer, Int. J. Radiat. Oncol. Biol. Phys. 31, 827-831 (1995).
40. Hallum, A. V., 3rd, Alberts, D. S., Lippman, S. M., Inclan, L., Shamdas, G. J., Childers, J. M., Surwit, E. A., Modiano, M., and Hatch, K. D. Phase II study of 13-cis-retinoic acid plus interferon-α2a in heavily pretreated squamous carcinoma of the cervix, Gynecol. Oncol. 56, 382-386 (1995).
41. Lippman, S. M., Kavanagh, J. J., Paredes, M., Delgadillo, F., Hong, W. K., Figuerda, F., Olguin, A., Freedman, R. S., Massimini, G., Holdener, E. E., and Krakoff, I. H. 13-cis-Retinoic acid (13cRA), interferon-α2a (IFN-α2a) and radiotherapy for locally advanced cancer of the cervix, Proc. Am. Soc. Clin. Oncol. 12, 257 (1993). [Abstract 816]
42. Mason, K. A., and Tofilon, P. J. Unexpected radiation protection with 13-cis-retinoic acid plus interferon α-2a, Cancer Chemother. Pharmacol. 33, 435-437 (1994).
43. Ortaldo, J. R., and McCoy, J. L. Protective effects of interferon in mice previously exposed to lethal irradiation, Radiat. Res. 81, 262-266 (1980).
44. Neta, R., and Oppenheim, J. J. Cytokines in therapy of radiation injury, Blood 72, 1093-1095 (1988).
45. Majewski, S., Szmurlo, A., Marczak, M., Jablonska, S., and Bollag, W. Synergistic effect of retinoids and interferon a on tumor-induced angiogenesis: Anti-angiogenic effect on HPV-harboring tumor cell lines, Int. J. Cancer 57, 81-85 (1994).
46. Ahn, W. S., Lippman, S. M., Kavanagh, J. J., Silva, E. G., Hong, W. K., Krakoff, I. H., and Hittelman, W. N. Biological basis of response of cervical squamous cell carcinoma to alpha interferon and 13-cis-retinoic acid, Proc. Am. Assoc. Cancer Res. 34 (1993). [Abstract 446]