Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat

Pharmacology Biochemistry and Behavior

Volumn 54, Issue 2, 1996, Pages 377-383

  Desole, Maria S ^a   Esposito, Giovanni ^a   Fresu, Luigia ^a   Migheli, Rossana ^a   Sircana, Sara ^a   Delogu, Rosaria ^a   Miele, Maddalena ^a   Miele, Egidio ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

Allopurinol; Brainstem; MPTP; Oxidative stress; Rat; Striatum

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; 5 HYDROXYINDOLEACETIC ACID; ALLOPURINOL; ASCORBIC ACID; DEHYDROASCORBIC ACID; DIHYDROXYPHENYLACETIC ACID; DOPAMINE; GLUTATHIONE; HOMOVANILLIC ACID; HYPOXANTHINE; NORADRENALIN; SEROTONIN; URIC ACID; XANTHINE; XANTHINE OXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG DISPOSITION; DRUG POTENTIATION; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEUROPHARMACOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0029894966     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02161-2     Document Type: Article

References (35)

1. Adams, Jr., J. D.; Odunze, I. N. Oxygen free radicals and Parkinson's disease. Free Rad. Biol. Med. 10:161-169; 1991.
2. Anderson, M. E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113:348-355; 1985.
3. Bates, T. E.; Heales, S. J. R.; Davies, S. E. C.; Boakye, P.; Clark, J. B. Effects of 1-methyl-4-phenylpiridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. J. Neurochem. 63:640-648; 1994.
4. Becker, B. B. Towards the physiological function of uric acid. Free Rad. Biol. Med. 14:615-631; 1993.
5. Bondy, S. C.; LeBel, C. P. The relationship between excitotoxicity and oxidative stress in the central nervous system. Free Rad. Biol. Med. 14:633-642; 1993.
6. Caskey, C. T.; Ashton, D. N.; Wyngaarden, J.B. Enzymology of feed-back inhibition of glutamine phosphoribosylpyropfosphate amidotransferase by purine ribonucleotides. J. Biol. Chem. 239: 2570-2579; 1964.
7. Chan, P.; DeLanney, R. E.; Irwin, I.; Langston, J. R.; Di Monte, D. Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain. J. Neurochem. 57:348-351; 1991.
8. Chiueh, C. C.; Markey, S. P.; Burns, R. S.; Johannessen, J. P.; Pert, A.; Kopin, I. J. Neurochemical and behavioral effects of systemic and intranigral administration on N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the rat. Eur. J. Pharmacol. 100: 189-194; 1984.
9. Church, W. H.; Ward, V. L. Uric acid is reduced in the substantia nigra in Parkinson's disease: effects on dopamine oxidation. Brain Res. Bull. 33:419-425; 1994.
10. Desole, M. S.; Esposito, G.; Enrico, P.; Miele, M.; Fresu, L.; De Natale, G.; Miele, E.; Grella, G. Effects of ageing on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxic effects on striatum and brainstem in the rat. Neurosci. Lett. 159:143-146; 1993.
11. +) levels in the striatal synaptosomes of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated rat. Neurosci. Lett. 161:121-123; 1993.
12. Desole, M. S.; Esposito, G.; Migheli, R.; Fresu, L.; Sircana, S.; Miele, M.; De Natale, G.; Miele, E. Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neurosci. Lett. 182:73-76; 1995.
13. Desole, M. S.; Miele, M.; Esposito, G.; Fresu, L. G.; Migheli, R.; Zangani, D.; Sircana, S.; Grella, G.; Miele, E. Neuronal antioxidant system and MPTP-induced oxidative stress in the striatum and brainstem of the rat. Pharmacol. Biochem. Behav. 51: 581-592; 1995.
14. Forno, L. S.; Langston, J. W.; DeLanney, L. E.; Irwin I.; Ricaurte, G. A. Locus coeruleus lesions and eosinophilic inclusions in MPTP-treated monkeys. Ann. Neurol. 20:449-455; 1986.
15. Hallman, H.; Olson, L.; Johnsson, G. Neurotoxicity of the meperidine analogue N-methyM-phenyl-1,2,6-tetrahydropyridine on brain catecholamine neurons in the mouse. Eur. J. Pharmacol. 97:133-136; 1984.
16. Jarvis, M. F.; Wagner, G. C. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the rat: characterization and age-dependent effects. Synapse 5:104-112; 1990.
17. +) induces oxidative stress in rodent. Life Sci. 38:743-749; 1986.
18. Kelley, W. N.; Rosenbloom, F. M.; Miller, J.; Seegmiller, J. E. An enzymatic basis for variation in response to allopurinol. N. Engl. J. Med. 278:287-293; 1986.
19. Lam, D. K. C.; Daniel, P. M. The influx of ascorbic acid into the rat brain. Quart. J. Exp. Physiol. 71:483-490; 1986.
20. MacGregor, M. J.; Higgins, M. J.; Stone, T. W. Ascorbate or allopurinol protect against kainate-induced neurotoxicity. Br. J. Pharmacol. 112:281P; 1994.
21. Majewska, M. D.; Bell, J. A.; London, E. D. Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate. Brain Res. 537:328-332; 1990.
22. Martenson, J.; Meister, A. Glutathione deficiency decrease tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects. Proc. Natl. Acad. Sci. 88:4656-4660; 1991.
23. Miele, M.; Esposito G.; Sircana, S.; Zangani, D.; Migheli, R.; Fresu, M. L.; Desole, M. S. Effetcs of allopurinol on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurochemical changes in the striatum and in the brainstem of the rat. Neurosci. Lett 183:155-158; 1995.
24. Niki, E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am. J. Clin. Nutr. 54:1119S-1124S; 1991.
25. Pellegrini-Giampietro, E.; Cherici, G.; Alesiani, M.; Carlà, V.; Moroni, F. Excitatory amino acid release from rat hippocampal slices as a consequence of free-radical formation. J. Neurochem. 51:1960-1963; 1988.
26. Rossetti, Z. L.; Sotgiu, A.; Sharp, D. E.; Hadjicostantinou, M. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro. Biochem. Pharmacol. 37:4573-4574; 1988.
27. Scotcher, K. P.; Irwin, I.; DeLanney, L. E.; Langstom, J. W.; Di Monte, D. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on ATP level in mouse brain synaptosomes. J. Neurochem. 54:1295-1301; 1990.
28. Sevanian, A.; Davies, K. J. A.; Hochstein, P. Serum urate as an antioxidant for ascorbic acid. Am. J. Clin. Nutr. 54:129S-134S; 1991.
29. Shenk, J. O.; Miller, E.; Gaddis, R.; Adams, R. N. Homeostatic control of ascorbate concentrations in CNS extracellular fluid. Brain Res. 253:353-356; 1982.
30. Spector, R.; Lorenzo, A. V. Specificity of ascorbic acid transport system of the central nervous system. Amer. J. Physiol. 226: 1468-1473; 1974.
31. +) nigral toxicity in the rat by prior decortication or MK-801 treatment. A stereological estimate of neuronal loss. Neurobiol. Aging 14:295-301; 1993.
32. + neurotoxicity by N-methyl-D-aspartate antagonists. Nature 349:414-418; 1991.
33. Wallace, R. A.; Boldry, R.; Schmittgen, T.; Miller, D.; Uretsky, N. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on monoamine neurotransmitters in mouse brain and heart. Life Sci. 35:285-291; 1984.
34. + in vivo. Eur. J. Pharmacol. 243:241-247; 1993.
35. Yu, T. F.; Gutman, A. B. Effect of allopurinol on serun and urinary uric acid in primary and secondary gout. Am. J. Med. 37: 885-898; 1964.