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Volumn 7, Issue 1, 1996, Pages 21-28

Protein folding, nucleation phenomena and delayed neurodegeneration in Alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid; APP; Plaques; Prion; Protein folding

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E;

EID: 0029894683     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.1996.7.1.21     Document Type: Review
Times cited : (6)

References (61)
  • 1
    • 0025779179 scopus 로고
    • Solution structures of beta peptide and its constituent fragments: Relation to amyloid deposition
    • Barrow CJ, Zagorski MG. Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition. Science 1991; 253: 179-182.
    • (1991) Science , vol.253 , pp. 179-182
    • Barrow, C.J.1    Zagorski, M.G.2
  • 2
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid beta protein toxicity
    • Behl C, Davis JB, Lesley R, Schubert D. Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 1994; 77: 817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 3
    • 0002089018 scopus 로고
    • Clinical genetics of familial Alzheimer's disease
    • Terry RD, Katzman R, Bick KL, eds, New York: Raven Press
    • Bird TD. Clinical genetics of familial Alzheimer's disease. In: Terry RD, Katzman R, Bick KL, eds, Alzheimer's Disease. New York: Raven Press, 1994.
    • (1994) Alzheimer's Disease
    • Bird, T.D.1
  • 4
    • 0345557724 scopus 로고
    • Diagnosis of Alzheimer's disease - Development of cytoskeletal changes and staging of Alzheimer related intraneuronal pathology
    • Braak H, Braak E. Diagnosis of Alzheimer's disease - development of cytoskeletal changes and staging of Alzheimer related intraneuronal pathology. Neurobiol Aging 1994; 15: S141.
    • (1994) Neurobiol Aging , vol.15
    • Braak, H.1    Braak, E.2
  • 7
    • 0027526419 scopus 로고
    • Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
    • Cai XD, Golde TE, Younkin SG. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 1993; 259: 514-516.
    • (1993) Science , vol.259 , pp. 514-516
    • Cai, X.D.1    Golde, T.E.2    Younkin, S.G.3
  • 10
    • 0027177237 scopus 로고
    • The cellular pathology associated with Alzheimer beta-amyloid deposits in non-demented aged individuals
    • Coria F, Moreno A, Rubio I, Garcia MA, Morato E, Mayor F, Jr. The cellular pathology associated with Alzheimer beta-amyloid deposits in non-demented aged individuals. Neuropathol Appl Neurobiol 1993; 19: 261-268.
    • (1993) Neuropathol Appl Neurobiol , vol.19 , pp. 261-268
    • Coria, F.1    Moreno, A.2    Rubio, I.3    Garcia, M.A.4    Morato, E.5    Mayor Jr., F.6
  • 11
    • 0027410176 scopus 로고
    • Beta A4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 French centenarians
    • Delaere P, He Y, Fayet G, Duyckaerts C, Hauw JJ. Beta A4 deposits are constant in the brain of the oldest old: an immunocytochemical study of 20 French centenarians. Neurobiol Aging 1993; 14: 191-194.
    • (1993) Neurobiol Aging , vol.14 , pp. 191-194
    • Delaere, P.1    He, Y.2    Fayet, G.3    Duyckaerts, C.4    Hauw, J.J.5
  • 12
    • 0025210629 scopus 로고
    • Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease
    • Dickson DW, Wertkin A, Mattiace LA, Fier E, Kress Y, Davies P, Yen SH. Ubiquitin immunoelectron microscopy of dystrophic neurites in cerebellar senile plaques of Alzheimer's disease. Acta Neuropathol 1990; 79: 486-493.
    • (1990) Acta Neuropathol , vol.79 , pp. 486-493
    • Dickson, D.W.1    Wertkin, A.2    Mattiace, L.A.3    Fier, E.4    Kress, Y.5    Davies, P.6    Yen, S.H.7
  • 13
    • 0026730350 scopus 로고
    • Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation
    • Dyrks T, Dyrks E, Hartmann T, Masters C, Beyreuther K. Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation. J Biol Chem 1992; 267: 18210-18217.
    • (1992) J Biol Chem , vol.267 , pp. 18210-18217
    • Dyrks, T.1    Dyrks, E.2    Hartmann, T.3    Masters, C.4    Beyreuther, K.5
  • 14
    • 0028872558 scopus 로고
    • Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: Implications for the pathogenesis and treatment of Alzheimer disease
    • Evans KC, Berger EP, Cho CG, Weisgraber KH, Lansbury PT. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease. Proc Natl Acad Sci USA 1995; 92: 763-767.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 763-767
    • Evans, K.C.1    Berger, E.P.2    Cho, C.G.3    Weisgraber, K.H.4    Lansbury, P.T.5
  • 15
    • 0028012879 scopus 로고
    • Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G→T change at position 2149 of the amyloid precursor protein gene
    • Farlow M, Murrell J, Ghetti B, Unverzagt F, Zeldenrust S, Benson M. Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G→T change at position 2149 of the amyloid precursor protein gene. Neurology 1994; 44: 105-111.
    • (1994) Neurology , vol.44 , pp. 105-111
    • Farlow, M.1    Murrell, J.2    Ghetti, B.3    Unverzagt, F.4    Zeldenrust, S.5    Benson, M.6
  • 17
    • 0026539090 scopus 로고
    • Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
    • Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 1992; 255: 728-730.
    • (1992) Science , vol.255 , pp. 728-730
    • Golde, T.E.1    Estus, S.2    Younkin, L.H.3    Selkoe, D.J.4    Younkin, S.G.5
  • 18
    • 0023132387 scopus 로고
    • Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease
    • Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 1987; 235: 877-880.
    • (1987) Science , vol.235 , pp. 877-880
    • Goldgaber, D.1    Lerman, M.I.2    McBride, O.W.3    Saffiotti, U.4    Gajdusek, D.C.5
  • 19
    • 0026325645 scopus 로고
    • Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion
    • Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. J Neurosci 1991; 11: 3783-3793.
    • (1991) J Neurosci , vol.11 , pp. 3783-3793
    • Haass, C.1    Hung, A.Y.2    Selkoe, D.J.3
  • 21
    • 0025275241 scopus 로고
    • Molecular determinants of amyloid deposition in Alzheimer's disease: Conformational studies of synthetic beta-protein fragments
    • Halverson K, Fraser PE, Kirschner DA, Lansbury PT, Jr. Molecular determinants of amyloid deposition in Alzheimer's disease: conformational studies of synthetic beta-protein fragments. Biochemistry 1990; 29: 2639-2644.
    • (1990) Biochemistry , vol.29 , pp. 2639-2644
    • Halverson, K.1    Fraser, P.E.2    Kirschner, D.A.3    Lansbury Jr., P.T.4
  • 23
    • 0028919919 scopus 로고
    • Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome
    • Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down syndrome. Ann Neurol 1995; 37: 294-299.
    • (1995) Ann Neurol , vol.37 , pp. 294-299
    • Iwatsubo, T.1    Mann, D.M.2    Odaka, A.3    Suzuki, N.4    Ihara, Y.5
  • 24
    • 0027425060 scopus 로고
    • The C-terminus of the beta protein is critical in amyloidogenesis
    • Jarrett JT, Berger EP, Lansbury PT Jr. The C-terminus of the beta protein is critical in amyloidogenesis. Ann NY Acad Sci 1993; 695: 144-148.
    • (1993) Ann NY Acad Sci , vol.695 , pp. 144-148
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury Jr., P.T.3
  • 25
    • 0027195933 scopus 로고
    • Seeding "one-dimensional crystallization" of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
    • Jarrett JT, Lansbury PT Jr. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell 1993; 73: 1055-1058.
    • (1993) Cell , vol.73 , pp. 1055-1058
    • Jarrett, J.T.1    Lansbury Jr., P.T.2
  • 26
    • 0024232950 scopus 로고
    • Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging
    • Joachim CL, Duffy LK, Morris JH, Selkoe DJ. Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging. Brain Res 1988; 474: 100-111.
    • (1988) Brain Res , vol.474 , pp. 100-111
    • Joachim, C.L.1    Duffy, L.K.2    Morris, J.H.3    Selkoe, D.J.4
  • 27
    • 0025110182 scopus 로고
    • Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage
    • Koh JY, Yang LL, Cotman CW. Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 1990; 533: 315-320.
    • (1990) Brain Res , vol.533 , pp. 315-320
    • Koh, J.Y.1    Yang, L.L.2    Cotman, C.W.3
  • 28
    • 0026693596 scopus 로고
    • In pursuit of the molecular structure of amyloid plaque: New technology provides unexpected and critical information
    • Lansbury PT Jr. In pursuit of the molecular structure of amyloid plaque: new technology provides unexpected and critical information. Biochemistry 1992; 31: 6865-6870.
    • (1992) Biochemistry , vol.31 , pp. 6865-6870
    • Lansbury Jr., P.T.1
  • 29
    • 0026547582 scopus 로고
    • Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology
    • Lantos PL, Luthert PJ, Hanger D, Anderton BH, Mullan M, Rossor M. Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology. Neurosci Lett 1992; 137: 221-224.
    • (1992) Neurosci Lett , vol.137 , pp. 221-224
    • Lantos, P.L.1    Luthert, P.J.2    Hanger, D.3    Anderton, B.H.4    Mullan, M.5    Rossor, M.6
  • 31
    • 0028762647 scopus 로고
    • Excitatory amino-acids as a final common pathway for neurologic disorders
    • Lipton SA, Rosenberg PA. Excitatory amino-acids as a final common pathway for neurologic disorders. NEJM 1994; 330: 613-622.
    • (1994) NEJM , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 33
    • 0025365306 scopus 로고
    • The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease
    • Mann DM, Jones D, Prinja D, Purkiss MS. The prevalence of amyloid (A4) protein deposits within the cerebral and cerebellar cortex in Down's syndrome and Alzheimer's disease. Acta Neuropathol 1990; 80: 318-327.
    • (1990) Acta Neuropathol , vol.80 , pp. 318-327
    • Mann, D.M.1    Jones, D.2    Prinja, D.3    Purkiss, M.S.4
  • 34
    • 0025600931 scopus 로고
    • Diffuse plaques do not accentuate synapse loss in Alzheimer's disease
    • Masliah E, Terry RD, Mallory M, Alford M, Hansen LA. Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am J Pathol 1990; 137: 1293-1297.
    • (1990) Am J Pathol , vol.137 , pp. 1293-1297
    • Masliah, E.1    Terry, R.D.2    Mallory, M.3    Alford, M.4    Hansen, L.A.5
  • 36
    • 0026570528 scopus 로고
    • β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
    • Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 1992; 12: 376-389.
    • (1992) J Neurosci , vol.12 , pp. 376-389
    • Mattson, M.P.1    Cheng, B.2    Davis, D.3    Bryant, K.4    Lieberburg, I.5    Rydel, R.E.6
  • 38
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
    • Murrell J, Farlow M, Ghetti B, Benson M. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 1991; 253: 97-98.
    • (1991) Science , vol.253 , pp. 97-98
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.4
  • 39
    • 0025971426 scopus 로고
    • Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease
    • Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 1991; 541: 163-166.
    • (1991) Brain Res , vol.541 , pp. 163-166
    • Namba, Y.1    Tomonaga, M.2    Kawasaki, H.3    Otomo, E.4    Ikeda, K.5
  • 40
    • 0028925377 scopus 로고
    • Prion protein peptides induce α-helix to β-sheet conformational transitions
    • Nguyen J, Baldwin MA, Cohen FE, Prusiner SB. Prion protein peptides induce α-helix to β-sheet conformational transitions. Biochemistry 1995; 34: 4186-4192.
    • (1995) Biochemistry , vol.34 , pp. 4186-4192
    • Nguyen, J.1    Baldwin, M.A.2    Cohen, F.E.3    Prusiner, S.B.4
  • 41
    • 0027438964 scopus 로고
    • Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease
    • Nochlin D, VanBelle G, Bird TD, Sumi SM. Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease. Alzheimer Dis Assoc Disord 1993; 7: 212-222.
    • (1993) Alzheimer Dis Assoc Disord , vol.7 , pp. 212-222
    • Nochlin, D.1    VanBelle, G.2    Bird, T.D.3    Sumi, S.M.4
  • 43
    • 0025992417 scopus 로고
    • In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity
    • Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 1991; 563: 311-314.
    • (1991) Brain Res , vol.563 , pp. 311-314
    • Pike, C.J.1    Walencewicz, A.J.2    Glabe, C.G.3    Cotman, C.W.4
  • 44
    • 0028981219 scopus 로고
    • Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity
    • Pike CJ, Walencewicz Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, Cotman CW. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. J Neurochem 1995; 64: 253-265.
    • (1995) J Neurochem , vol.64 , pp. 253-265
    • Pike, C.J.1    Walencewicz Wasserman, A.J.2    Kosmoski, J.3    Cribbs, D.H.4    Glabe, C.G.5    Cotman, C.W.6
  • 45
    • 0027302886 scopus 로고
    • Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid
    • Pike CJ, Cotman CW. Cultured GABA-immunoreactive neurons are resistant to toxicity induced by beta-amyloid. Neuroscience 1993; 56: 269-274.
    • (1993) Neuroscience , vol.56 , pp. 269-274
    • Pike, C.J.1    Cotman, C.W.2
  • 46
    • 0027374494 scopus 로고
    • A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid beta protein (A beta P) in phospholipid bilayer membranes
    • Pollard HB, Rojas E, Arispe N. A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid beta protein (A beta P) in phospholipid bilayer membranes. Ann NY Acad Sci 1993; 695: 165-168.
    • (1993) Ann NY Acad Sci , vol.695 , pp. 165-168
    • Pollard, H.B.1    Rojas, E.2    Arispe, N.3
  • 47
    • 0023684537 scopus 로고
    • Differences between vascular and plaque core amyloid in Alzheimer's disease
    • Prelli F, Castano E, Glenner GG, Frangione B. Differences between vascular and plaque core amyloid in Alzheimer's disease. J Neurochem 1988; 51: 648-651.
    • (1988) J Neurochem , vol.51 , pp. 648-651
    • Prelli, F.1    Castano, E.2    Glenner, G.G.3    Frangione, B.4
  • 48
    • 0021752457 scopus 로고
    • Purification and structural studies of a major scrapie prion protein
    • Prusiner SB, Groth DF, Bolton DC, Kent SB, Hood LE. Purification and structural studies of a major scrapie prion protein. Cell 1984; 38: 127-134.
    • (1984) Cell , vol.38 , pp. 127-134
    • Prusiner, S.B.1    Groth, D.F.2    Bolton, D.C.3    Kent, S.B.4    Hood, L.E.5
  • 50
    • 0027265297 scopus 로고
    • Molecular pathology of Alzheimer's disease
    • Rossor MN. Molecular pathology of Alzheimer's disease. J Neurol Neurosurg Psychiatry 1993; 56: 583-586.
    • (1993) J Neurol Neurosurg Psychiatry , vol.56 , pp. 583-586
    • Rossor, M.N.1
  • 51
    • 0026712151 scopus 로고
    • Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: A high-resolution transmission electron microscope study of tangles and senile plaque core amyloid corrected and republished with original paging
    • article originally printed in Brain Res 1992 Sep 11;590(1-2): 164-79.
    • Ruben GC, Iqbal K, Wisniewski HM, Johnson JE Jr, Grundke-Iqbal I. Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein tau: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid [corrected and republished with original paging, article originally printed in Brain Res 1992 Sep 11;590(1-2): 164-79]. Brain Res 1993; 602: 164-179.
    • (1993) Brain Res , vol.602 , pp. 164-179
    • Ruben, G.C.1    Iqbal, K.2    Wisniewski, H.M.3    Johnson Jr., J.E.4    Grundke-Iqbal, I.5
  • 53
    • 0027166738 scopus 로고
    • Amyloid beta peptides act directly on single neurons
    • Simmons MA, Schneider CR. Amyloid beta peptides act directly on single neurons. Neurosci Lett 1993; 150: 133-136.
    • (1993) Neurosci Lett , vol.150 , pp. 133-136
    • Simmons, M.A.1    Schneider, C.R.2
  • 54
    • 0025373508 scopus 로고
    • Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing
    • Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990; 248: 492-495.
    • (1990) Science , vol.248 , pp. 492-495
    • Sisodia, S.S.1    Koo, E.H.2    Beyreuther, K.3    Unterbeck, A.4    Price, D.L.5
  • 55
    • 0025376092 scopus 로고
    • Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease
    • Spillantini MG, Goedert M, Jakes R, Klug A. Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease. Proc Natl Acad Sci USA 1990; 87: 3947-3951.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 3947-3951
    • Spillantini, M.G.1    Goedert, M.2    Jakes, R.3    Klug, A.4
  • 58
    • 0029010736 scopus 로고
    • Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer's disease and systemic amyloidosis
    • Tennent GA, Lovat LB, Pepys MB. Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer's disease and systemic amyloidosis. Proc Natl Acad Sci USA 1995; 92: 4299-4303.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4299-4303
    • Tennent, G.A.1    Lovat, L.B.2    Pepys, M.B.3
  • 59
    • 0026423852 scopus 로고
    • Spongiform encephalopathies. The prion's progress
    • Weissmann C. Spongiform encephalopathies. The prion's progress [news]. Nature 1991; 349: 569-571.
    • (1991) Nature , vol.349 , pp. 569-571
    • Weissmann, C.1
  • 61
    • 0024990330 scopus 로고
    • Neurotrophic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
    • Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 1990; 250: 279-282.
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.A.1    Duffy, L.K.2    Kirschner, D.A.3


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