Major histocompatibility class II molecules in the CNS: Increased microglial expression at the onset of narcolepsy in a canine model

Journal of Neuroscience

Volumn 16, Issue 15, 1996, Pages 4588-4595

  Tafti, Mehdi ^a,c   Nishino, Seiji ^a   Aldrich, Michael S ^b   Liao, Wennie ^a   Dement, William C ^a   Mignot, Emmanuel ^a  

^a STANFORD UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

development; gene expression; immunohistochemistry; MHC class II; microglia; narcolepsy; Northern analysis

Indexed keywords

HLA DR2 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DOG; GENE EXPRESSION; HLA SYSTEM; IMMUNOHISTOCHEMISTRY; MICROGLIA; NARCOLEPSY; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL;

EID: 0029894018     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-15-04588.1996     Document Type: Article

References (69)

1. Aldrich MS (1990) Narcolepsy. N Engl J Med 323:388-394.
2. Aldrich MS, Naylor MW (1989) Narcolepsy associated with lesions of the diencephalon. Neurology 39:1505-1508.
3. Aldrich MS, Prokopowicz G, Ockert K, Hollingsworth Z, Penney JB, Albin RL (1994) Neurochemical studies of human narcolepsy: alpha-adrenergic receptor autoradiography of human narcoleptic brain and brainstem. Sleep 17:598-608.
4. Baker TL, Dement WC (1985) Canine narcolepsy-cataplexy syndrome: evidence for an inherited monoaminergic-cholinergic imbalance. In: Brain mechanisms of sleep (McGinty DJ, Drucker-Colin R, Morrison A, Parmengiani P, eds), pp 199-233. New York: Raven.
5. Boje KM, Arora PK (1992) Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res 587:250-256.
6. Bordier C (1981) Phase separation of integral membrane proteins in Triton X-114 solution. J Biol Chem 256:1604-1607.
7. Colton CA, Gilbert DL (1987) Production of Superoxide anions by a CNS macrophage, the microglia. FEBS Lett 223:284-288.
8. Cuzner ML, Hayes GM, Newcomb J, Woodroofe MN (1988) The nature of inflammatory components during demyelination in multiple sclerosis. J Neuroimmunol 20:203-209.
9. Erlich S, Itabashi H (1986) Narcolepsy: a neuropathological study. Sleep 9:126-132.
10. Esiri MM, McGee J (1986) Monoclonal antibody to macrophages (EBM/ 11) labels macrophages and microglial cells in human brain. J Clin Pathol 39:615-621.
11. Fredrikson S, Carlander B, Billiard M, Link H (1990) CSF immune variable in patients with narcolepsy. Acta Neurol Scand 81:253-254.
12. Frei K, Siepl C, Groscurth P, Bodmer S, Schwerdel C, Fontana A (1987) Antigen presentation and tumor cytotoxicity by interferon-gamma treated microglial cells. Eur J Immunol 17:1271-1278.
13. Frei K, Malipiero UV, Leist TP, Zinkernagel RM, Schwab ME, Fontana A (1989) On the cellular source and function of interleukin 6 produced in the CNS in viral diseases. Eur J Immunol 19:689-694.
14. Ganter S, Northoff H, Mennel D, Gebicke-Haerter PJ (1992) Growth control of cultured microglia. J Neurosci Res 33:218-230.
15. Gehrmann J, Monaco S, Kreutzberg GW (1991) Spinal cord microglial cells and DRG satellite cells rapidly respond to transection of the rat sciatic nerve. Restor Neurol Neurosci 2:181-198.
16. Gehrmann J, Banati RB, Kreutzberg GW (1993a) Microglia in the immune surveillance of the brain: human microglia constitutively express HLA-DR molecules. J Neuroimmunol 48:189-198.
17. Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg G (1993b) Microglial involvement in experimental autoimmune inflammation of the peripheral and central nervous system. Glia 7:50-59.
18. Giulian D, Baker TJ, Shin L, Lachman LB (1986) Interleukin 1 of the CNS is produced by ameboid microglia. J Exp Med 164:594-604.
19. Graeber MB, Streit WJ, Buringer D, Sparks L, Kreutzberg GW (1992) Ultrastructural location of major histocompatibility complex (MHC) class II positive perivascular cells in histologically normal human brain. J Neuropathol Exp Neurol 51:303-311.
20. Haga S, Akai K, Ishii T (1989) Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using novel monoclonal antibody. Acta Neuropathol (Berl) 77:569-575.
21. Hayes GM, Woodroofe MN, Cuzner ML (1987) Microglia are the major cell type expressing MHC class II in human white matter. J Neurol Sci 80:25-37.
22. Hickey WF, Kimura H (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 239:290-292.
23. Jordan FL, Thomas WW (1988) Brain macrophages: question of origin and interrelationships. Brain Res Rev 13:165-178.
24. Kapas L, Hong L, Cady AB, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM (1992) Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-alpha and TNF-alpha fragments. Am J Physiol 263:R708-R715.
25. Kapas L, Fang J, Krueger JM (1994a) Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Res 664:189-196.
26. Kapas L, Shibata M, Kimura M, Krueger JM (1994b) Inhibition of nitric oxide synthesis suppresses sleep in rabbits. Am J Physiol 266:R151-R157.
27. Kawamata T, Akiyarna H, Yamada T, McGeer PL (1992) Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 140:691-707.
28. Kish SJ, Mamelak M, Slimovitch C, Dixon LM, Lewis A, Shannak K, Distephano L, Chang LJ, Hornykiewitz O (1992) Brain neurotransmitter changes in human narcolepsy. Neurology 42:229-234.
29. Krueger JM, Walter J, Dinarello CA, Wolff SM, Chedid L (1984) Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol 246:R994-R999.
30. Krueger JM, Obal F, Opp M, Toth L, Johannsen L, Cady AB (1990) Somnogenic cytokines and models concerning their effects on sleep. Yale J Biol Med 63:157-172.
31. Lampson LA, Hickey WF (1986) Monoclonal antibody analysis of MHC expression in human brain biopsies: tissue ranging from "histologically normal" to that showing different levels of glial tumor involvement. J Immunol 136:4054-4062.
32. Lawson LJ, Perry VH, Dri P, Gordon S (1990) Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39:151-170.
33. Leverenz J, Petito CK, Morgello S (1988) Neuropathologic change in a patient with narcolepsy. Neurology 38:307.
34. Lim RKS, Liu C-N, Moffit RL (1960) A stereotaxic atlas of the dog's brain. Springfield, IL: J.L. Books.
35. Ling EA, Kaur C, Wong WC (1991) Expression of major histocompatibility complex and leukocyte common antigens in amoeboid microglia in postnatal rats. J Anat 177:117-126.
36. Luber-Narod J, Rogers J (1988) Immune system associated antigens expressed by cells of the human CNS. Neurosci Lett 94:17-22.
37. Mallat M, Houlgatte R, Brachet P, Prochiantz A (1989) Lipopolysaccharide-stimulated rat brain macrophages release NGF in vitro. Dev Biol 113:309-311.
38. Matsuki K, Juji T, Honda Y (1988) Immunological features in Japan. In: HLA and narcolepsy (Honda Y, Juji T, eds), pp 58-76. New York: Springer.
39. Matsuki K, Grumet FC, Lin X, Guilleminault C, Dement WC, Mignot E (1992) HLA DQB1-0602, rather than HLA DRw15(DR2), is the disease susceptibility gene in Black narcoleptics. Lancet 339:1052.
40. Matsumoto Y, Hara N, Tanaka R, Fujiwara M (1986) Immunohistochemical analysis of the rat CNS during experimental allergic encephalomyelitis, with special reference to la-positive cells with dendritic morphology. J Immunol 136:3668-3676.
41. Mattiace LA, Davies P, Dickson DW (1990) Detection of HLA-DR on microglia in the human brain is a function of both clinical and technical factors. Am J Pathol 136:1101-1114.
42. McGeer PL, Itagaki S, McGeer EG (1988) Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol (Berl) 76:550-557.
43. McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG (1993) Microglia in degenerative neurological disease. Glia 7:84-92.
44. Mignot E, Nishino S, Sharp L, Arrigoni J, Siegel JM, Reid MS, Edgar DM, Ciaranello RD, Dement WC (1991a) Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems. J Neurosci 13:1057-1064.
45. Mignot E, Wang C, Rattazzi C, Gaiser C, Lovett M, Guilleminault C, Dement WC, Grumet FC (1991b) Genetic linkage of autosomal recessive canine narcolepsy with an immunoglobulin μ chain switch-like segment. Proc Natl Acad Sci USA 88:3475-3478.
46. Mignot E, Lin X, Arrigoni J, Macaubas C, Olive F, Hallmeyer J, Underhill P, Guilleminault C, Dement WC, Grumet FC (1994) DQB1*0602 and DQA1*0102 are better markers than DR2 for narcolepsy in Caucasian and black Americans. Sleep 17:560-567.
47. Mignot E, Tafti M, Dement WC, Grumet FC (1995) Narcolepsy and immunity. Adv Neuroimmunol 5:23-37.
48. Murabe Y, Sano Y (1982) Morphological studies on neuroglia. V. Microglial cells in the cerebral cortex of the rat, with special reference to their possible involvement in synaptic function. Cell Tissue Res 223:493-506.
49. Nakajima K, Tsuzaki N, Nagata K, Takemoto N, Kohsaka S (1992) Production and secretion of plasminogen in cultured rat brain microglia. FEBS Lett 308:179-182.
50. Nakajima K, Nagata K, Kohsaka S (1994) Plasminogen mediates an interaction between microglia and dopaminergic neurons. Eur Neurol 34:10-16.
51. Nishino S, Tafti M, Reid MS, Shelton J, Siegel JM, Dement WC, Mignot E (1995) Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy. J Neuroscience 15:4806-4814.
52. Parkes JD, Welsh K, Langdon N, Lock CB (1988) Immune factors in narcolepsy in the United Kingdom. In: HLA and narcolepsy (Honda Y, Juji T, eds), pp 158-171. New York: Springer.
53. Perlmutter LS, Barron E, Chui HC (1990) Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease. Neurosci Lett 119:32-36.
54. Perry VH, Matyszak MK, Fearn S (1993) Altered antigen expression of microglia in the aged rodent CNS. Glia 7:60-67.
55. Raivich G, Moreno-Flores MT, Muller JC, Kreutzberg GW (1994) Regulation of microglial proliferation: colony-stimulating factors and their receptors. Neuropathol Appl Neurobiol 20:209-211.
56. Reid MS, Tafti M, Geary JN, Nishino S, Siegel JM, Dement WC, Mignot E (1994) Cholinergic mechanisms in canine narcolepsy. I. Modulation of cataplexy via local drug administration into the pontine reticular formation. Neuroscience 59:511-522.
57. Rogers J, Luber-Narod J, Styren SD, Civin WH (1988) Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol Aging 9:339-349.
58. Rubin RL, Hajdukovitch RM, Mitler MM (1988) HLA DR2 association with excessive somnolence in narcolepsy does not generalize to sleep apnea and is not accompanied by systemic autoimmune abnormalities. Clin Immunol Immunopathol 49:149-158.
59. Sasaki A, Nakazato Y (1992) The identity of cells expressing MHC class II antigens in normal and pathological human brain. Neuropathol Appl Neurobiol 18:13-26.
60. Sawada M, Kondo N, Suzumura A, Marunouchi T (1989) Production of tumor necrosis factor-alpha by microglia and astrocytes in culture. Brain Res 491:394-397.
61. Sedgwick JD, Schwender S, Gregersen R, Dorries R, Ter Meulen V (1993) Resident macrophages (ramified microglia) of the adult Brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive. J Exp Med 177:1145-1152.
62. Sobel RA, Ames MB (1988) Major histocompatibility complex molecule expression in the human central nervous system: immunohistochemical analysis of 40 patients. J Neuropath Exp Neural 47:19-28.
63. Sobel RA, Blanchette BW, Bhan AK, Colvin RB (1984) The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration. J Immunol 132:2402-2407.
64. Styren SD, Civin WH, Rogers J (1990) Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp Neurol 110:93-104.
65. Tafti M, Dement WC, Mignot E (1994) CNS expression of HLA Class II molecules in canine narcolepsy. Sleep Res 23:335.
66. Vass K, Lassmann H (1990) Intrathecal application of interferon-gamma: progressive appearance of MHC antigens within the nervous system. Am J Pathol 137:3170-3174.
67. Weinstein DL, Walker DG, Akiyama H, McGeer PL (1990) Herpes simplex virus type I infection of the CNS induces MHC antigen expression on rat microglia. J Neurosci Res 26:55-65.
68. Wekerle H, Linington C, Lassmann H, Meyermann R (1986) Cellular immune reactivity within the CNS. Trends Neurosci 9:271-277.
69. Woodroofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML (1986) Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis: possible role for microglia in lesion growth. J Neurol Sci 74:135-152.