Immunohistochemical detection of bcl-2 protein in adenocarcinoma and Non-Neoplastic cellular compartments of the lung

Modern Pathology

Volumn 9, Issue 5, 1996, Pages 555-559

  Rao, Sudha K ^a   Krishna, Murli ^a   Woda, Bruce A ^a   Savas, Lou ^a   Fraire, Armando E ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Adenocarcinoma; bcl 2 protein; Bronchioles; Immunostaining; Lung

Indexed keywords

PROTEIN BCL 2;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG SMALL CELL CANCER; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; BRONCHI; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 0029893789     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer S: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334, 1990
2. Le Brun DP, Warnke RA, Cleary ML: Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol 142:743, 1993
3. Jong D, Prins FA, Mason DY, et al.: Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells. Cancer Res 54:256, 1994
4. Tsujimoto Y, Croce CM: Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A 83:5214, 1986
5. Lu Q-L, Elia G, Lucas S, Thomas JA: Bcl-2 protooncogene expression in Epstein-Barr-virus-associated nasopharyngeal carcinoma. Int J Cancer 53:29, 1993
6. Pezzella F, Turley H, Kuzu I, et al.: Bcl-2 protein in non-small cell lung carcinoma. N Engl J Med 329:690, 1993
7. Ben-Ezra JM, Kornstein MJ, Grimes MM, Krystal G: Small cell carcinomas of the lung express the bcl-2 protein. Am J Pathol 145:1036, 1994
8. Hague A, Moorgen M, Hicks D, Chapman M, Paraskeva C: Bcl-2 expression in human colorectal adenomas and carcinomas. Oncogene 9:3367, 1994
9. Bosari S, Moneghin, L, Graziani D, et al.: Bcl-2 oncoprotein in colorectal hyperplastic polyps, adenomas and adenocarcinomas. Hum Pathol 26:534, 1995
10. Joensuu H, Pylkkanen L, Toikkanen S: Bcl-2 protein expression and long-term survival in breast cancer. Am J Pathol 145:1191, 1994
11. Van den Oord JJ, Vandeghinste N, Ley MD, Wolf-Peeters CD: Bcl-2 expression in human melanocytes and melanocytic tumors. Am J Pathol 145:294, 1994
12. Reed JC, Meister L, Shigeki T, et al.: Differential expression of Bcl-2 protooncogene in neuroblastoma and other human tumor cell lines of neural origin. Cancer Res 51:6529, 1991
13. Nakasu S, Nakasu Y, Nioka H, Nakajima M, Handa J: Bcl-2 protein expression in tumors of the central nervous system. Acta Neuropathol 88:520, 1994
14. Heck K, Pyle P, Bruner JM: Bcl-2 expression in cerebellar medulloblastomas. Brain Pathol 4:430, 1994
15. Ikegaki N, Katsumata M, Minna J, Tsujimoto Y: Expression of bcl-2 in small cell lung carcinoma cells. Cancer Res 54:6, 1994
16. Cleary ML, Smith SD, Sklar J: Cloning and structural analysis of CDNAS for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47: 19, 1986
17. Weiss LM, Warnke RA, Sklar J, Cleary ML: Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas. N Engl J Med 317:1185, 1987
18. Yunis JJ, Mayer MG, Arnesen MA, et al.: Bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma. N Engl J Med 320:1047, 1989
19. McDonnell TJ, Troncoso P, Brisbay SM, et al.: Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 52:6940, 1992
20. Elias JM. Immunohistopathology. A Practical Approach to Diagnosis, pp 1-90. Chicago, American Society of Clinical Pathology Press, 1990
21. Ritter JH, Dresler CM, Wick MR: Expression of bcl-2 protein in Stage TINOMO non small cell lung carcinoma. Hum Pathol 26:1227, 1995