Quality assurance procedure for monitoring tacrolimus (FK506) concentrations in whole blood by IMx assay

Therapeutic Drug Monitoring

Volumn 18, Issue 3, 1996, Pages 267-272

  Alak, Ala M ^a   Lizak, Paula P ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

FK506; IMx assay; Microparticle immunoassay; Tacrolimus; Validation procedure

Indexed keywords

TACROLIMUS;

ARTICLE; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MONITORING; HEALTH CARE QUALITY; HUMAN; PRIORITY JOURNAL;

HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOSUPPRESSIVE AGENTS; OBSERVER VARIATION; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS; TACROLIMUS;

EID: 0029893727     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007691-199606000-00008     Document Type: Article

References (7)

1. Goto T, Kino T, H. Hatanaka H, et al. Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant Proc 1987;19:4-8.
2. Goto T, Kino T, H. Hatanaka H, et al. FK 506: Historical perspectives. Transplant Proc 1991;23:13-2717.
3. Peters DH, Fitton A, Plosker GL, Faulds D. Tacrolimus, a review of its pharmacology, and therapeutic potential in hepatic and renal transplantation. Drugs 1993;46:746-94.
4. Tamura K, Kobayashi M, K. Hashimoto K, et al. A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc 1987;19:23-9.
5. Grenier FC, Loczkiw J, M. Bergmann M, et al. A whole blood FK506 assay for the IMx analyzer. Transplant Proc 1991;23:2748-9.
6. D'Ambrosio R, Girzaitis N, Jusko WJ. Validation and quality assurance program for monitoring tacrolimus (FK 506) concentrations in plasma and whole blood. Ther Drug Monit 1993;15:414-26.
7. D'Ambrosio R, Girzaitis N, Jusko WJ. Multicenter comparison of tacrolimus (FK506) whole blood concentrations as measured by the Abbott IMx analyzer and enzyme immunoassay with methylene chloride extraction. Ther Drug Monit 1994;16:287-92.