Synthesis and sar of dhodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 10, 1996, Pages 1145-1150

  Curtis, Neil R ^a   Kulagowski, Janusz J ^a   Leeson, Paul D ^a   Mawer, Ian M ^a   Ridgill, Mark P ^a   Rowley, Michael ^a   Grimwood, Sarah ^a   Marshall, George R ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIIODOTYROSINE DERIVATIVE; 5,7 DICHLORO 1,2,3,4 TETRAHYDRO 4 (3 PHENYLUREIDO) 2 QUINOLINECARBOXYLIC ACID; ALPHA AMINO ACID; AMINO ACID; AROMATIC COMPOUND; DIIODOTYROSINE; GLYCINE; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENOL DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; THYROID HORMONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ISOMER; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0029893706     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00187-4     Document Type: Article

References (12)

1. Meldrum, B., Ed. Excitatory Amino Acid Antagonists; Blackwell Scientific Publications: Oxford, 1991.
2. Leeson, P.D.; Iversen, L.L. J. Med. Chem. 1994, 37, 4053.
3. Leeson, P.D.; Baker, R.; Carling, R.W.; Curtis, N.R.; Moore, K.W.; Williams, B.J.; Foster, A.C.; Donald, A.E.; Kemp, J.A.; Marshall, G.R. J. Med. Chem. 1991, 34, 1243.
4. Leeson, P.D.; Carling, R.W.; Moore, K.W.; Moseley, A.M.; Smith, J.D.; Stevenson, G.; Chan, T.; Baker, R.; Foster, A.C.; Grimwood, S.; Kemp, J.A.; Marshall, G.R.; Hoogsteen, K. J. Med. Chem. 1992, 35, 1954.
5. Kulagowski, J.J.; Baker, R.; Curtis, N.R.; Mawer, I.M.; Moseley, A.M.; Ridgill, M.P.; Rowley, M.; Stansfield, I.; Foster, A.C.; Grimwood, S.; Hill, R.H.; Kemp, J.A.; Marshall, G.R.; Saywell, K.L.; Tricklebank, M.D.; Leeson, P.D. J. Med. Chem. 1994, 37, 1402.
6. Mitsunobu, O. Synthesis 1981, 1.
7. Kometani, T.; Watt, D.S.; Ji, T. Tetrahedron Lett. 1985, 26, 2043.
8. Grimwood, S.; Moseley, A.M.; Carling, R.W.; Leeson, P.D.; Foster, A.C. Mol. Pharmacol. 1992, 41, 923.
9. Snell, L.D.; Morter, R.S.; Johnson, K.M. Eur. J. Pharmacol. 1988, 156, 105.
10. Williams, B.J.; Leeson, P.D.; Hannah, G.; Baker, R. J. Chem. Soc., Chem. Commun. 1989, 1740
11. Foster, A.C.; Kemp, J.A.; Leeson, P.D.; Grimwood, S.; Donald, A.E.; Marshall, G.R.; Priestley, T.; Smith, J.D.; Carling, R.W. Mol. Pharmacol. 1992, 41, 914.
12. Snell, L.D.; Morter, R.S.; Johnson, K.M. Eur. J. Pharmacol. 1988, 156, 105.