High level expression of human tissue kallikrein in the circulation induces hypotension in transgenic mice

Immunopharmacology

Volumn 32, Issue 1-3, 1996, Pages 105-107

  Song, Qing ^a   Chao, Julie ^a   Chao, Lee ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Albumin promoter; Aprotinin; Human tissue kallikrein; Hypotension; Transgenic mice

Indexed keywords

ALBUMIN; KALLIKREIN;

ANIMAL EXPERIMENT; BLOOD PRESSURE; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HYPOTENSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE;

EID: 0029893456     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/0162-3109(95)00065-8     Document Type: Conference Paper

References (8)

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2. Berry TD, Hasstedt SJ, Hunt SC, Wu LL, Smith JB, Ash O, Kuida H, Williams RR. A gene for high urinary kallikrein may protect against hypertension in Utah kindreds. Hypertension 1989; 13: 3-8.
3. Carretero OA, Polomski C, Hampton A, Scicli AG. Urinary kallikrein, plasma renin and aldosterone in New Zealand genetically hypertensive (GH) rats. Clin Exp Pharmacol Physiol 1976; 3: 55-59.
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6. Pinkert CA, Ornitz DM, Brinster RL, Palmiter RD. An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient liver-specific expression in transgenic mice. Genes Dev 1987; 1: 268-276.
7. Wang C, Chao L, Chao J. Direct gene delivery of human tissue kallikrein reduces blood pressure in spontaneously hypertensive rats. J Clin Invest 1995; 95: 1710-1716.
8. Wang J, Xiong W, Yang Z, Davis T, Dewey MJ, Chao J, Chao L. Human tissue kallikrein induces hypotension in transgenic mice. Hypertension 1994; 23: 236-243.