Influence of fluvoxamine on tacrine metabolism in vitro: Potential implication for the hepatotoxicity in vivo

Fundamental and Clinical Pharmacology

Volumn 10, Issue 2, 1996, Pages 156-157

  Becquemont, L ^a   Le Bot, M A ^b   Riche, C ^b   Beaune, P ^a  

^a INSERM   (France)

^b FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

Author keywords

cytochrome P450; drug metabolism; fluvoxamine; tacrine

Indexed keywords

CYTOCHROME P450 ISOENZYME; ETHOXYRESORUFIN DEETHYLASE; FLUVOXAMINE; RECOMBINANT ENZYME; TACRINE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG METABOLISM; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; LIVER TOXICITY; PRIORITY JOURNAL; YEAST;

EID: 0029893339     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1996.tb00159.x     Document Type: Article

References (5)

1. Bellamine A, Gautier JC, Urban P, Pompon D. Chimeras of the human cytochrome P450 1A familly produced in yeast. Accumulation in microsomal membranes, enzyme kinetics and stability. Eur J Biochem 1994;225:1005-13
2. Brøsen K, Skjelbo E, Rasmussen BB, Poulsen HE, Loft S. Fluvoxamine is a potent inhibitor of cytochrome P450 1A2. Biochem Pharmacol 1993;45:1211-4
3. Madden S, Woolf TF, Pool WF, Park BK. An investigation into the formation of stable, protein-reactive and cytotoxic metabolites from tacrine in vitro. Biochem Pharmacol 1993;46:13-20
4. Park TH, Tachiki KH, Summers WK, Kling D, Fitten J, Perryman K, Spidell K, Kling AS. Isolation and the fluorimetric, high-performance liquid chromatographic determination of tacrine. Anal Biochem 1986;159:358-62
5. Watkins PB, Zimmerman HJ, Knapp MJ, Gracon SI, Lewis KW. Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA 1994;271:992-8