True insulin and intact proinsulin levels in acromegalic patients

European Journal of Endocrinology

Volumn 134, Issue 5, 1996, Pages 549-553

  Tavares, Edelweiss F ^a   Dalbosco, Ivaldir S ^a   Abucham, Julio ^a   Russo, Ewaldo M K ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b NONE   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE; INSULIN; PROINSULIN;

ACROMEGALY; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HYPERINSULINISM; MALE; PRIORITY JOURNAL;

EID: 0029893295     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1340549     Document Type: Article

References (35)

1. Gordon DA, Hill FM, Ezrin C. Acromegaly: a review of 100 cases. Can Med Assoc J 1991;87:1106-9
2. Wass JAH, Cudworth AG, Bottazzo GF, Woodrow JC, Besser GM. An assessment of glucose intolerance in acromegaly and its response to medical treatment. Clin Endocrinol 1980;12:53-9
3. Bratusch-Marrain PR, Smith D, De Fronzo RA. The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metabol 1982;55:973-82
4. Foss MC, Saad MJA, Paccola GMGF, Paula FJA, Piccinato CE, Moreira AC. Peripheral glucose metabolism in acromegaly. J Clin Endocrinol Metabol 1991;72:1048-53
5. Beck P, Schalch DS, Parker ML, Kipnis DM, Daughaday WH. Correlative studies of growth hormone and insulin plasma concentrations with metabolic abnormalities in acromegaly. J Lab Clin Med 1965;66:366-79
6. Sonksen PH, Greenwood FC, Ellis JP, Lowy C, Rutherford A, Nabarro JDN. Changes of carbohydrate tolerance in acromegaly with progress of the disease and in response to treatment. J Clin Endocrinol Metabol 1967;27:1418-30
7. Trimble ER, Atkinson AB, Buchanan KD, Hadden DR. Plasma glucagon and insulin concentrations in acromegaly. J Clin Endocrinol Metab 1980;51:626-31
8. Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte Jr D. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 1987;30:698-702
9. Saad MF, Kahn SE, Nelson RG, Pettitt DJ, Knowler WC, Schwartz ME, et al. Disproportionately elevated proinsulin in Pima Indians with non-insulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1990;70:1247-53
10. Temple RC, Carrington CA, Luzio SD, Owens DR, Schneider AE, Sobey WJ, et al. Insulin deficiency in non-insulin-dependent diabetes. Lancet 1989;1:293-5
11. Gallows JA, Hooper SA, Spradlin CT, Howey DC, Frank BH, Bowsher RR, et al. Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacological studies, and clinical trial experience. Diabetes Care 1992;15:666-92
12. Tillil H, Frank BH, Pekar AH, Broelch C, Rubenstein AH, Polonsky KS. Hypoglycemic potency and metabolic clearance rate of intravenously administered human proinsulin and metabolites. Endocrinology 1990;127:2418-22
13. Heding LG. Determination of total serum insulin (IRI) in insulin-treated diabetic patients. Diabetologia 1972;8:260-6
14. Miles LEM, Hales CN. Labelled antibodies and immunological assay systems. Nature 1968;219:186-9
15. Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 1975;256:495-7
16. Gray IP, Siddle K, Frank BH, Hales CN. Characterization and use in immunoradiometric assay of monoclonal antibodies directed against human proinsulin. Diabetes 1987;36:684-8
17. Sobey WJ, Beer SF, Carrington CA, Clark PMS, Frank BH, Gray IP, et al. Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J 1989;260:535-41
18. Toivonen E, Hemmila I, Marniemi J, Jorgensen PN, Zeuthen J, Lovgren T. Two-site time-resolved immunofluorometric assay of human insulin. Clin Chem 1986;32:637-40
19. Storch MJ, Petersen KJ, Licht T, Kerp L. Recognition of human insulin and proinsulin by monoclonal antibodies. Diabetes 1985;34:808-11
20. Chevenne D, Ruiz J, Lohman L, Laudat A, Leblanc H, Gray P, et al. Immunoradiometric assay of human intact proinsulin applied to patients with type 2 diabetes, impaired glucose tolerance, and hyperandrogenism. Clin Chem 1994;40:754-7
21. Kao PC, Taylor RL, Service FJ. Proinsulin by immunochemilumometric assay for the diagnosis of insulinoma. J Clin Endocrinol Metab 1994;78:1048-51
22. Mako ME. Starr JI, Rubenstein AH. Circulating proinsulin in patients with maturity onset diabetes. Am J Med 1987;63:865-9
23. WHO Study Group on Diabetes Mellitus 1985; WHO Tech Rep Ser No. 727
24. Vieira JGH, Lombardi MT, Nishida SK. Monoclonal antibody-based immunoenzymometric assay for serum growth hormone. Braz J Med Bid Res 1990;23:293-6
25. Furlanetto RW, Underwood LE, Van Wyk JJ, D'Ercole AJ. Stimulation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay. J Clin Invest 1977;60:648-57
26. Vieira JGH, Nishida SK, Lombardi MT, Tachibana TT, Obara LH, Dalbosco IS, et al. Comparison of the determination of insulin by a monoclonal antibody-based immunofluorimetric assay and by radioimmunoassay. Braz J Med Biol Res 1995;28:537-43
27. Dalbosco IS, Vieira JGH, Nishida SK, Lombardi MT, Moisés RCS, Coifman R, et al. A specific and highly sensitive time-resolved fluoroimmunoassay for human proinsulin. Braz J Med Biol Res 1996;29:193-9
28. Wynn V, Doar J. Some effects of oral contraceptives on carbohydrate metabolism. Lancet 1966;II:715
29. Rhodes CJ, Alarcon C. Perspectives in diabetes. What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances in understanding the proinsulin-processing mechanism. Diabetes 1994;43:511-7
30. Koivisto VA, Järvinen HY, Hartling SG, Pelkonen R. The effect of exogenous hyperinsulinemia on proinsulin secretion in normal man, obese subjects, and patients with insulinoma. J Clin Endocrinol Metab 1986;63:1117-20
31. Shiraishi I, Iwamoto Y, Kuzuya T, Matsuda A, Kumakura S. Hyperinsulinaemia in obesity is not accompanied by an increase in serum proinsulin/insulin ratio in groups of human subjects with and without glucose intolerance. Diabetologia 1991;34 (10):737-41
32. Haffner SM, Mykkänen L, Stern MP, Valdez RA, Heisserman JA, Bowsher RR. Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes 1993;42: 1297-302
33. Ikeda T, Terasawa H, Ishimura M, Ochi H, Ohtani I, Fujiyama K, et al. Correlation between blood pressure and plasma insulin in acromegaly. J Intern Med 1993;234:61-3
34. Slowinska-Srzednicka J, Zgliczynki S, Soszynski P, Zgliczynski W, Jeske W. High blood pressure and hyperinsulinaemia in acromegaly and in obesity. Clin Exp Hypertens Theor Pract 1989;A11:407-25
35. Nagi DK, Hendra TJ, Ryle AJ, Cooper TM, Temple RC, Clark PMS, et al. The relationship of concentrations of insulin, intact proinsulin and 32-33 split proinsulin with cardiovascular risk factors in type 2 (non-insulin-dependent) diabetic subjects. Diabetologia 1990;33:532-7