Inhibition of GH in maternal separation may be mediated through altered serotonergic activity at 5-HT2A and 5-HT2C receptors

Psychoneuroendocrinology

Volumn 21, Issue 2, 1996, Pages 219-235

  Katz, Lawrence M ^a   Nathan, Lauren ^a   Kuhn, Cynthia M ^a   Schanberg, Saul M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5 HT2A; 5 HTP; Fluoxetine; Maternal separation; Rats; Receptor; Serotonin

Indexed keywords

5 HYDROXYTRYPTOPHAN; FLUOXETINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; SEROTONIN 1C RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN AGONIST; SOMATOSTATIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HYPOTHALAMUS; MALE; MATERNAL DEPRIVATION; NEUROENDOCRINOLOGY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC NERVE;

ANIMALS; ANIMALS, NEWBORN; AROUSAL; BRAIN; BRAIN MAPPING; FEMALE; GROWTH HORMONE; HUMANS; HYPOTHALAMUS; MALE; MATERNAL DEPRIVATION; NEURAL PATHWAYS; NOREPINEPHRINE; OBJECT ATTACHMENT; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPECIES SPECIFICITY;

EID: 0029893184     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4530(95)00043-7     Document Type: Article

References (76)

1. Aghajanian GK (1972) Chemical-feedback regulation of serotonin-containing neurons in brain. Ann NY Acad Sci 193:86-94.
2. Aguilar E, Rancha A, Tenasempere M, Pinilla L (1994) Serotoninergic control of prolactin secretion in prepubertal male rats. Eur J Endocrinol 131:547-554.
3. Alhaider AA, Ageel AM, Ginawi OT (1993) The quipazine-and TFMPP-increased conditioned avoidance response in rats: role of 5-HT1C/5-HT2 receptors. Neuropharmacology 32:1427-1432.
4. Anderson KN, Anderson LE, Glanz WD (Eds) (1994) Mosby's Medical, Nursing, and Allied Health Dictionary, 4th Edition. Mosby Year Book, Inc., St Louis, MO, USA.
5. Arimura A, Fishback JB (1981) Somatostatin: regulation of secretion. Neuroendocrinology 33:246-256.
6. Arnold MA, Fernstrom JD (1981) L-tryptophan injection enhances pulsatile growth hormone secretion in the rat. Endocrinology 108:331-335.
7. Artigas F (1993) 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol Sci 14:262.
8. Baird A, Wehrenberg WB, Ling N (1984) Ontogeny of the response to growth hormone releasing factor. Reg Peptides 10:23-28.
9. Bartolome JV, Johnston JG, Schanberg SM (1994) The inhibition of liver ornithine decarboxylase expression in neonatal rats by maternal separation or CNS b-endorphin is independent of the pituitary. Life Sci 54:679-686.
10. Butler SR, Schanberg SM (1977) Effect of MD on polyamine metabolism in pre-weanling rat brain and heart. Life Sci 37:877-884.
11. Butler SR, Suskind MR, Schanberg SM (1978) Maternal behavior as a regulator of polyamine biosynthesis in brain and heart of the developing rat pup. Science 199:445-447.
12. Carr JA, Saland LC, Samora A, Benavidez S, Krobert K (1991) In vivo effects of serotonergic agents on alpha-melanocyte-stimulating hormone secretion. Neuroendocrinology 54:616-622.
13. Cella SG, De Gennaro Colonna V, Locatelli V, Moiraghi V, Loche S, Wehrenberg WB, Müller EE (1990) Growth hormone (GH) autofeedback action in the neonatal rat: involvement of GH-releasing hormone and somatostatin. J Endocrinol 124:199-205.
14. Cella SG, Locatelli V, Bondiolotti GP, Pintor C, Loche S, Provezza M, Müller EE (1988) Epinephrine mediates the growth hormone-releasing effect of galanin in infant rats. Endocrinology 122:855-859.
15. Cella SG, Locatelli V, De Gennaro V, Puggioni R, Pintor C, Müller EE (1985) Human pancreatic growth hormone (GH)-releasing hormone stimulates GH synthesis and release in infant rats. An in vivo study. Endocrinology 116:574-577.
16. Chihara K, Arimura A, Schally AV (1979) Effect of intraventricular injection of dopamine, norepinephrine, acetylcholine, and 5-hydroxytryptamine on immunoreactive somatostatin release into rat hypophyseal portal blood. Endocrinology 104:1656-1662.
17. Cocchi D, Gil-Ad I, Panerai AE, Locatelli V, Müller EE (1977) Effect of 5-hydroxytryptophan on prolactin and growth hormone release in the infant rat: evidence for different neurotransmitter mediation. Neuroendocrinology 24:1-13.
18. Dedeoglu A, Fisher LA (1991) Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms. J Pharmacol Exp Ther 259:1027-1034.
19. Di Sciullo A, Bluet-Pajot MT, Mounier F, Oliver C, Schmidt B, Kordon C (1990) Changes in anterior pituitary hormone levels after serotonin1A receptor stimulation. Endocrinology 127:567-572.
20. Eck JB, Kuhn CM (1992) Effect of ether stress on growth hormone during development in the neonatal rat. Neuroendocrinology 56:605-610.
21. Evoniuk GE, Kuhn CM, Schanberg SM (1979) The effect of tactile stimulation on serum growth hormone and tissue ornithine decarboxylase activity during maternal deprivation in rat pups. Comm Psychopharmacol 3:363-370.
22. Field TM, Schanberg SM, Scafidi F, Bauer CR, Vega-Lahr N, Garcia R, Nystrom J, Kuhn CM (1986) Effects of tactile/kinesthetic stimulation in pre-term neonates. Pediatrics 77:654-658.
23. Frasier SD, Rallison ML (1972) Growth retardation and emotional deprivation: relative resistance to treatment with human growth hormone. J Pediatr 80:603-609.
24. Fuller RW, Wong DT (1977) Inhibition of serotonin reuptake. Federation Proc 36:2154-2158.
25. Hagan MM, Moss DE (1993) Effect of naloxone and antidepressants on hyperphagia produced by peptide YY. Pharm Biochem Behav 45:941-944.
26. Harlow HF, Zimmermann RR (1959) Affectional responses in the infant monkey. Science 130:421-432.
27. Helke CJ, Thor KB, Phillips ET (1991) 5-hydroxytryptamine 1C/2 agonists in the thoracic spinal cord: cardiovascular effects and binding sites in the intermediolateral cell column. J Pharmacol Exp Ther 259:1335-1343.
28. Hinde R, Spencer-Booth, Y (1971) Effects of brief separation from mother on rhesus monkeys. Science 173:111-118.
29. Hjorth S, Sharp T (1991) Effect of the 5-HT1A agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life Sci 48:1779-1786.
30. Holtzman SG, Steinfels GF (1994) Monoamine systems in the discriminative effects of spiradoline, a kappa-opioid agonist. Pharm Biochem Behav 47:575-578.
31. Hoyer D (1988) Functional correlates of serotonin 5-HT1 recognition sites. J Rec Res 8:59-81.
32. Hynes MD, Lochner MA, Bemis KG, Hymson DL (1985) Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors. Life Sci 36:2317-2323.
33. Jansson J, Ishikawa K, Katakami H, Frohman LA (1987) Pre- and postnatal developmental changes in hypothalamic content of rat growth hormone-releasing factor. Endocrinology 120:525-530.
34. 2-adrenergic systems. Neuroendocrinology 57:195-203.
35. Kuhn CM, Eck JB, Francis R (1991) The neuroendocrine effect of neonatal 'handling'. Soc Neurosci Ann Mtg.
36. Kuhn CM, Evoniuk G, Schanberg SM (1979) Loss of tissue sensitivity to growth hormone during maternal deprivation in rats. Life Sci 25:2089-2097.
37. Kuhn CM, Grignolo A, Schanberg SM (1983) Ontogeny of stress effects on ornithine decarboxylase activity in rats. Pharm Biochem Behav 18:669-672.
38. Kuhn CM, Pauk J, Schanberg SM (1990) Endocrine responses to mother-infant separation in developing rats. Dev Psychobiol 23:395-410.
39. Kuhn CM, Schanberg SM (1981) Maturation of CNS control of growth hormone secretion in rats. J Pharm Exp Ther 217:152-156.
40. Kuhn CM, Schanberg SM, Field T, Symanski R, Zimmerman E, Scafidi F, Roberts J (1991) Tactile-kinesthetic stimulation effects on sympathetic and adrenocortical function in preterm infants. J Pediatr 119:434-440.
41. Lamberts SJ, Verleun T, Oosterom R (1985) The mechanism of action of cyproheptadine on prolactin release by cultured anterior pituitary cells. Life Sci 36:2257-2262.
42. Lamberts SWJ, MacLeod RM (1979) Studies on the effect of cyproheptadine on growth hormone secretion. Proc Soc Exp Bio Med 162:116-120.
43. Lesch KP, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Murphy DL (1993) Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. Brain Res Mol Brain Res 17:31-35.
44. Martin LL, Sanders-Bush E (1982) Comparison of the pharmacological characteristics of 5 HT1 and 5 HT2 binding sites with those of serotonin autoreceptors which modulate serotonin release. Naunyn-Schmiedeberg's Arch Pharm 321:165-170.
45. Meller E, Bohmaker K (1994) Differential receptor reserve for 5-HT1A receptor-mediated regulation of plasma neuroendocrine hormones. J Pharm Exp Ther 271:1246-1252.
46. Middlemiss DN, Fozard JR (1983) 8-hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol 90:151-153.
47. Milburn CM, Peroutka SJ (1989) Characterization of [3H]quipazine binding to 5-hydroxytryptamine3 receptors in rat brain membranes. J Neurochem 52:1787-1792.
48. Mosko SS, Jacobs BL (1977) Electrophysiological evidence against negative neuronal feedback from the forebrain controlling midbrain raphe unit activity. Brain Res 119:291-303.
49. Müller EE, Nisticó G (1989) Neurotransmitter, neuromodulators, and neuromediators. In: Müller EE, Nisticó G (Eds) Brain Messengers and the Pituitary. Academic Press, San Diego, pp 94, 97-106, 224-228.
50. Müller EE, Nisticò G, Scapagnini U (1977) Hypothalamic releasing and inhibiting hormones. In: Müller EE, Nisticò G, Scapagnini U (Eds) Neurotransmitters and Pituitary Function. Academic Press, New York, pp 149-162.
51. Murakami Y, Kato Y, Kabayama Y, Tojo K, Inoue T, Imura H (1986) Involvement of growth hormone (GH)-releasing factor in GH secretion induced by serotonergic mechanisms in conscious rats. Endocrinology 119:1089-1092.
52. Oliver C, Giraud P, Lissitzky JC, Cote J, Boudouresque F, Gillioz P, Conte-Devolx B (1982) Influence of endogenous somatostatin on growth hormone and thyrotropin secretion in neonatal rats. Endocrinology 110:1018-1022.
53. Pauk J, Kuhn CM, Field TM, Schanberg SM (1986) Positive effects of tactile vs. kinesthetic or vestibular stimulation on neuroendocrine and ODC activity in maternally deprived rat pups. Life Sci 39:2081-2087.
54. Patton GR, Gardner LI (1963) Growth Failure in Maternal Deprivation. Charles C. Thomas, Springfield, IL, USA.
55. Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23:163-178.
56. Powell GF, Brasel JA, Blizzard RM (1967) Emotional deprivation and growth retardation simulating idiopathic hypopituitarism I. Clinical evaluation of the syndrome. N Engl J Med 276:1271-1278.
57. Powell GF, Brasel JA, Raiti S, Blizzard RM (1967) Emotional deprivation and growth retardation simulating idiopathic hypopituitarism II. Endocrinologic evaluation of the syndrome. N Engl J Med 276:1279-1283.
58. Pritchette DB, Bach AWJ, Wozny M, Taleb O, Del Toso R, Shish JC, Seeburg PH (1988) Structure and functional expression of cloned rat serotonin 5-HT-2 receptor. EMBO J 7:4135-4140.
59. Rayner PH, Rudd BT (1973) Emotional deprivation in three siblings associated with functional pituitary growth hormone deficiency. Austr Paediatr J 9:79-84.
60. Richardson SB, Hollander CS, Prasad JA, Hirooka Y (1981) Somatostatin release from rat hypothalamus in vitro: effects of melatonin and serotonin. Endocrinology 109:602-606.
61. Rieutort M (1981) Ontogenetic development of the inhibition of growth hormone release by somatostatin in the rat: in vivo and in vitro (perfusion) study. J Endocrinology 89:355-363.
62. Rittenhouse PA, Bakkum EA, Van de Kar LD (1991) Evidence that the serotonin agonist, DOI, increases renin secretion and blood pressure through both central and peripheral 5-HT2 receptors. J Pharmacol Exp Ther 259:58-65.
63. Scafidi FA, Field TM, Schanberg SM, Bauer CR, Tucci K, Roberts J, Kuhn CM (1990) Massage stimulates growth in preterm infants: a replication. Infant Behav Dev 13:167-188.
64. Schanberg SM, Evoniuk G, Kuhn CM (1984) Tactile and nutritional aspects of maternal care: specific regulators of neuroendocrine function and cellular development. Proc Soc Exp Bio Med 175:135-146.
65. Schanberg SM, Field TM (1987) Sensory deprivation stress and supplemental stimulation in the rat pup and preterm human neonate. Child Dev 58:1431-1447.
66. Schanberg SM, Kuhn CM (1980) Maternal deprivation: an animal model of psychosocial dwarfism. In: Usdin E, Sourkes TL, Youdim MBH (Eds) Enzymes and Neurotransmitters in Mental Disease. Wiley, London, pp 373-393.
67. Schechter LE, Simansky KJ (1988) 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) exerts an anorexic action that is blocked by 5-HT2 antagonists in rats. Psychopharmacology 94:342-346.
68. Schmidt MJ, Fuller RW, Wong DT (1988) Fluoxetine, a highly selective serotonin reuptake inhibitor: a review of preclinical studies. Br J Psychiatry 153(S3):40-46.
69. Shaffer D, Campbell M (1994) Reactive attachment disorder of infancy or early childhood. In: Frances A, Pincus HA, First HB (Eds) Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, Fourth Edition. American Psychiatric Association, Washington, pp 116-118.
70. Sills MA, Wolfe BB, Frazer A (1984) Determination of selective and nonselective compounds for the 5-HT1A and 5-HT1B receptor subtypes in rat frontal cortex. J Pharmacol Exp Ther 231:480-487.
71. Slotkin TA, Bartolome J (1986) Role of ornithine decarboxylase and the polyamines in nervous system development: a review. Brain Res Bull 17:307-320.
72. Smythe GA, Brandstater JF, Lazarus L (1975) Serotonergic control of rat growth hormone secretion. Neuroendocrinology 17:245-257.
73. Smythe GA, Lazarus L (1973) Blockade of serotonin induced GH secretion in rats by melatonin and cyproheptadine. Horm Metab Res 5:227.
74. Stuart M, Lazarus L, Smythe GA, Moore S, Sara V (1976) Biogenic amine control of growth hormone secretion in the fetal and neonatal rat. Neuroendocrinology 22:337-342.
75. Tannenbaum GS (1991) Neuroendocrine control of growth hormone secretion. Acta Paediatr Scand Suppl 372:5-16.
76. Willoughby JO, Menadue MF, Liebelt H (1987) Activation of serotonin receptors in the medial basal hypothalamus stimulates growth hormone receptors in the unanesthetized rat. Brain Res 404:319-322.