Stress- and mitogen-activated signal transduction in hematopoietic cells

Current Opinion in Hematology

Volumn 3, Issue 1, 1996, Pages 27-34

  Kieran, Mark W ^a   Zon, Leonard I ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGENIC AGENT; PROTEIN KINASE;

CELL STIMULATION; CELL SURVIVAL; GENE EXPRESSION REGULATION; HEMATOPOIETIC CELL; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION;

EID: 0029893138     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-199603010-00005     Document Type: Review

References (130)

1. Marshall CJ: Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185. An excellent review.
2. Herskowitz I: MAP kinase pathways in yeast: for mating and more. Cell 1995, 80:187-197. An excellent review.
3. Hill CS, Treisman R: Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 1995, 80:199-211. An excellent review, particularly on the regulation of transcription.
4. Heldin CH: Dimerizatlon of cell surface receptors in signal transduction. Cell 1995, 80:213-223.
5. Hunter T: Protein kinase and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995, 80:225-236.
6. Cohen GB, Ren R, Baltimore D: Modular binding domains in signal transduction. Cell 1995, 80:237-248.
7. Neer EJ: Heterotrimeric G proteins: organizers of transmembrane signals. Cell 1995, 80:249-257.
8. Hunter T, Karin M: The regulation of transcription by phosphorylation. Cell 1992, 70:375-387.
9. Cobb MH, Goldsmith EJ: How MAP kinases are regulated. J Biol Chem 1995, 270:14843-14846. An excellent review.
10. Karin M: Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr Opin Cell Biol 1994, 6:415-424.
11. Thelen M, Wirthmueller U: Phospholipases and protein kinases during phagocyte activation. Curr Opin Immunol 1994, 6:106-112.
12. Downey GP, Fukushima T, Fialkow L: Signaling mechanisms in human neutrophils. Curr Opin Hematol 1995, 2:76-88.
13. Schlessinger J: SH2/SH3 signalling proteins. Curr Opin Genet Dev 1994, 4:25-30.
14. Pelech SL, Sanghera JS: MAP kinases: charting the regulatory pathways. Science 1992, 257:1355-1407.
15. Ammerer G: Sex, stress, and integrity: the importance of MAP kinases in yeast. Curr Opin Genet Dev 1994, 4:90-95.
16. Elion EA: Ste5: a meeting place for MAP kinases and their associates. Trends Cell Biol 1995, 5:322-327.
17. Zhou Z, Gartner A, Cade R, Ammerer G, Errede B: Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases. Mol Cell Biol 1993, 13:2069-2080.
18. Neiman AM, Herskowitz I: Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. Proc Natl Acad Sci U S A 1994, 91:3398-3402.
19. Cairns BR, Ramer SW, Kornberg RD: Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase. Genes Dev 1992, 6:1305-1318.
20. Stevenson BJ, Rhodes N, Errede B, Sprague GF Jr: Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein. Genes Dev 1992, 6:1293-1304.
21. McCaffrey G, Clay FJ, Kelsay K, Sprague GF Jr: Identification and regula tion of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. Mol Cell Biol 1987, 7:2680-2690.
22. Elion EA, Brill JA, Fink GR: FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transaction. Proc Natl Acad Sci U S A 1991, 88:9392-9396.
23. Choi K, Satterberg B, Lyons O, Elion E: Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisia. Cell 1994, 78:499-512. Identifies ste5 as the tethering factor that brings stell (MAPKKK), ste7 (MAPKK), and fus3 (MARK) together.
24. Printen JA, Sprague GF Jr: Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 1994, 138:609-619.
25. Hasson MS, Blinder D, Thorner J, Jenness DD: Mutational activation of the STE5 gene product bypasses the requirement for 6 protein β and γ subunits in the yeast pheromone response pathway. Mol Cell Biol 1994, 14:1054-1065.
26. Kranz JE, Satterberg B, Elion EA: The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5. Genes Dev 1994, 8:313-327.
27. Elion EA, Grisafl PL, Fink GR: FUS3 encodes a cdc2+/CD28-related kinase required for the transition from mitosis into conjugation. Cell 1990, 60:649-664.
28. Roberts RL, Fink GR: Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth. Genes Dev 1994, 8:2974-2985.
29. Boulton TG, Yancopoulos GD, Gregory JS, Slaughter C, Moomaw C, Hsu J, Cobb MH: An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science 1990, 249:64-67.
30. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD: ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 1991, 65:663-675.
31. Gotoh Y, Matsuda S, Okomura E, Kishimoto T, Kawasaki H, Suzuki K, Yahara I, Sakai H, Nishida E: Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF. EMBO J 1991, 10:2661-2668.
32. Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL: A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 1993, 260:315-319.
33. Coso OA, Chiariello M, Kalinek G, Kyriakis JM, Woodgett J, Gutkind JS: Transforming G protein-coupled receptors potently activate JNK (SAPK): evidence for a divergence from the tyrosine kinase signaling pathway. J Biol Chem 1995, 270:5620-5624.
34. Lange-Carter CA, Johnson GL: Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 1994, 265:1458-1461.
35. Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, Templeton DJ: Activation of stress-activated protein kinase MEKK1 phosphorylation. Nature 1994, 372:798-800. MEKK, which originally was thought to be a MEK activator, is capable of potent activation of SEK. This activates the SAPKs.
36. Sanchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI: Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-jun. Nature 1994, 372:794-797. Describes the cloning of SEK, the activator of SAPK/JNK.
37. Dérijard B, Raingeaud J, Barrett T, Wu I-H, Han J, Ulevitch RJ, Davis RJ: Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 1995, 297:682-685. This paper defines the process of multiple MAPK cascades in vertebrate cells.
38. Lin A, Minden A, Martinetto H, Claret F-X, Lange-Carter C, Mercurio F, Johnson GL, Karin M: Identification of a dual specificity kinase that activated the Jun kinases and p38-Mpk2. Science 1995, 268:286-290. Describes the cloning of the human homologue of SEK.
39. Yashar BM, Kelley C, Yee K, Errede B, Zon LI: Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Cell Biol 1993, 13:5738-5748. Documents the cloning of the Xenopus homologue of SEK.
40. Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR: The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994, 369:156-160. The cloning of the SAPKs allowed an in-depth look at stress activation.
41. Derijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037. A good biochemical study of the JNK1 enzyme.
42. Moriguchi T, Kawasaki H, Matsuda S, Gotoh Y, Nishida E: Evidence for multiple activators for stress-activated protein kinases/c-Jun amino-terminal kinases. J Biol Chem 1995, 270:12969-12972.
43. Han J, Lee J-D, Bibbs L, Ulevitch PJ: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 1994, 265:808-811. Documents the cloning of p38, a vertebrate homologue of the yeast HOG1 kinase.
44. Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda AR: A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994, 78:1027-1037. MAPKAP-2 kinase is a downstream target of the MAP kinases.
45. Anderson NG, Mailer JL, Tonks NK, Sturgill TW: Requirement for integra tion of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 1990, 343:651-653.
46. Gotoh Y, Matsuda S, Takenaka K, Hattori S, Iwamatsu A, Ishikawa M, Kosako H, Nishida E: Characterization of recombinant xenopus MAP kinase kinases mutated at potential phosphorylation sites. Oncogene 1994, 9:1891-1898.
47. 2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase. Proc Natl Acad Sci U S A 1994, 91:3142-3146.
48. Smeal T, Hibi M, Karin M: Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptlonal activity by protein kinase A. EMBO J 1994, 13:6006-6010.
49. Brach MA, Gruss H-J, Sott C, Herrmann F: the mitogenlc response to tumor necrosis factor alpha requires c-Jun/AP-1. Mol Cell Biol 1993, 13:4284-4290.
50. Trowbridge IS: A prototype for transmembrane protein tyrosine phosphatases. J Biol Chem 1991, 266:13517-13520.
51. Fialkow L, Chan CK, Rotin D, Grinstein S, Downey GP: Activation of the mitogen-activated protein kinase signaling pathway in neutrophils: role of oxidants. J Biol Chem 1994, 269:31234-31242.
52. Zheng CF, Guan KL: Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase. J Biol Chem 1993, 268:16116-16119.
53. Sun H, Charles C, Lau L, Tonks N: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 1993, 75:487-493.
54. Liu Y, Gorospe M, Yang C, Holbrook NJ: Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress: inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation. J Biol Chem 1995, 270:8377-8380.
55. Misra-Press A, Rim CS, Yao H, Roberson MS, Stork PJS: A novel mitogen-activated protein kinase phosphatase: structure, expression and regulation. J Biol Chem 1995, 270:14587-14596.
56. ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J 1993, 12:4211-4220.
57. Cook SJ: Inhibition of cAMP of Ras-dependent activation of Raf. Science 1993, 262:1069-1072.
58. Gerard C, Gerard NP: The pro-inflammatory seven-transmembrane segment receptors of the leukocyte. Curr Opin Immunol 1994, 6:140-145.
59. Grinstein S, Furuya W: Chemoattractant-induced tyrosine phosphorylation and activation of microtubule-associated protein kinase in human neutrophils. J Biol Chem 1992, 267:18122-18125.
60. Rollet E, Caon AC, Roberge CJ, Liao NW, Malawista SE, McColl SR, Naccache PH: Tyrosine phosphorylation in activated human neutrophils: comparison of the effects of different classes of agonists and identification of the signaling pathways involved. J Immunol 1994, 153:353-363.
61. Worthen GS, Avdi N, Buhl AM, Suzuki N, Johnson GL: FMLP activates Ras and Raf in human neutrophils: potential role in activation of MAP kinase. J Clin Invest 1994, 94:815-823.
62. Berkow RL, Dodson RW: Tyrosine-specific protein phosphorylation during activation of human neutrophils. Blood 1990, 75:2445-2452.
63. Akimura K, Utsumi T, Sato EF, Klostergaard J, Inoue M, Utsumi K: Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor α and granulocyte colony stimulating factor. Arch Biochem Biophys 1992, 298:703-709.
64. McColl SR, DiPersio JF, Caon AC, Ho P, Naccache PH: Involvement of tyrosine kinases in the activation of human peripheral blood neutrophils by granulocyte-macrophage colony-stimulating factor. Blood 1991, 78:1842-1852.
65. Gomez-Cambronero J, Wang E, Johnson G, Huang C-K, Sha'afi RI: Platelet-activating factor induces tyrosine phosphorylation in human neutrophils. J Biol Chem 1991, 266:6240-6245.
66. Grinstein S, Furuya W: Tyrosine phosphorylation and oxygen consumption induced by G proteins in neutrophils. Am J Physiol 1991, 260:C1019-C1027.
67. Gaudry M, Caon AC, Gilbert C, Lille S, Nacache PH: Evidence for the involvement of tyrosine kinases in the locomotory responses of human neutrophils. J Leukoc Biol 1992, 51:103-108.
68. 2-generatlon in response to tumor necrosis factor α and antibodies against CD18 and CD11a: evidence for a common and unique pattern of sensitivity to wortmannin and protein tyrosine kinase inhibitors. Biochem Biophys Res Commun 1993, 190:935-940.
69. Kharbanda S, Saleem A, Emoto Y, Stone R, Rapp U, Kife D: Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells. J Cell Biol 1994, 269:872-878. Mitogen-activated protein kinase cascades in myeloid cells are defined.
70. Liu MK, Herrera-Velit P, Brownsey RW, Reiner NE: CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and P44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol 1994, 153:2642-2652.
71. Ding J, Badway JA: Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myrlstoylated alanine-rich C kinase substrate. J Biol Chem 1993, 268:17326-17333.
72. Grinstein S, Furuya W, Butler JR, Tseng J: Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes. J Biol Chem 1993, 268:20223-20231.
73. Torres M, Hall FL, O'Neill K: Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J Immunol 1993, 150:1563-1577.
74. Blumer KJ, Johnson GL, Lange-Carter CA: Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C. Proc Natl Acad Sci U S A 1994, 91:4925-4929.
75. Miyazawa K, Hendrie PC, Mantel C, Wood K, Ashman LK, Broxmeyer HE: Comparative analysis of signaling pathways between mast cell growth (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-1, GTPase-activating protein, and mitogen-activated protein kinase. Exp Hematol 1991, 19:1110-1123.
76. Welham MJ, Duronio V, Sanghera JS, Pelech SL, Schrader JW: Multiple hematopoietic growth factors stimulate activation of mitogen-activated protein kinase family members. J Immunol 1992, 149:1683-1693.
77. Belka C, Wiegmann K, Adam D, Holland R, Neuloh, M, Herrmann F, Krönke M, Brach MA: Tumor necrosis factor (TNF)-α activates c-raf-1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. EMBO J 1995, 14:1156-1165.
78. mak in vitro. Oncogene 1993, 8:2259-2265.
79. Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA: Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 1993, 363:45-51.
80. Bollag G, McCormick F: Regulators and effectors of ras proteins. Annu Rev Cell Biol 1971, 7:601-606.
81. ras GTPase-activating protein. Proc Natl Acad Sci U S A 1992, 89:1587-1591.
82. Hipskind RA, Büscher D, Nordheim A, Baccarini M: Ras/MAP kinase-dependent and -independent signaling pathways target distinct ternary complex factors. Genes Dev 1994, 8:1803-1816.
83. TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 1992, 358:414-416.
84. Marais R, Wynne J, Treisman R: The SRC accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 1993, 73:381-393.
85. Belka C, Ahlers A, Sott C, Gaestel M, Herrmann F, Brach MA: Interleukin (IL)-6 signaling leads to phosphorylation of the small heat shock protein (Hsp)27 through activation of the MAP kinase and MAPKAP kinase 2 pathway in monocytes and monocytic leukemia cells. Leukemia 1995, 9:288-294.
86. Okuda K, Sanghera JS, Pelech SL, Kanakura Y, Hallek M, Griffin JD, Druker BJ: Granulocyte-macrophage colony-stimulating factor, interleukin-3, and Steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 1992, 79:2880-2887.
87. Carroll MP, May WS: Protein kinase C-mediated serine phosphorylation directly activates Raf-1 in murine hematopoietic cells. J Biol Chem 1994, 269:1249-1256.
88. Baccarini M, Sabatini DM, App H, Rapp UR, Stanley, ER: Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J 1990, 9:3649-3657.
89. Dosil M, Wang S, Lemischka IR: Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells. Mol Cell Biol 1993, 13:6572-6585.
90. Liu MK, Brownsey RW, Reiner NE: Gamma interferon induces rapid and coordinate activation of mitogen-activated protein kinase (extracellular signal-regulated kinase) and calcium-independent protein kinase C in human monocytes. Infect Immun 1994, 62:2722-2731.
91. Minami Y, Oishi I, Liu Z-J, Nakagawa S, Miyazaki T, Taniguchi T: Signal transduction mediated by the reconstituted IL-2 receptor: evidence for a cell type-specific function of IL-2 receptor-chain. J Immunol 1994, 152:5680-5690.
92. Shibuya H, Yoneyama M, Ninomiya-Tsuji J, Matsumoto K, Taniguchi T: IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Cell 1992, 70:57-67.
93. Miyasaki T, Liu Z-J, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Perlmutter RM, Taniguchi T: Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Cell 1995, 81:223-231. An excellent article about signal transduction in hematopoietic cells.
94. Matulonis U, Salgia R, Okuda K, Druker B, Griffin JD: Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. Exp Hematol 1993, 21:1460-1466.
95. Williamson EA, Boswell HS: Signal transduction during myeloid cell differentiation. Curr Opin Hematol 1995, 2:29-40.
96. Darnell JE, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264:1415-1421.
97. Grinstein S, Butler JR, Furuya W, L'Allemain G, Downey GP: Chemotactic peptides induce phosphorylation and activation of MEK-1 in human neutrophils. J Biol Chem 1994, 269:19313-19320.
98. Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, Riches DWH: TNFa rapidly activates the MEK/MAP kinase cascade in an MEKK-dependent, c-raf-1-independent fashion in mouse macrophages. Proc Natl Acad Sci U S A 1995, 92:1614-1618. Tumor necrosis factor α activates the MAPK cascade in macrophages.
99. Kharbanda S, Emoto Y, Kisaki H, Saleem A, Kufe D: 1-β-D-Arabinofuranosylcytosine activates serine/threonine protein kinases and c-jun gene expression in phorbol ester-resistant myeloid leukemia cells. Mol Pharmacol 1994, 46:67-72.
100. Lord KA, Abdollahi A, Hoffman-Liebermann B, Liebermann DA: Protooncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation. Mol Cell Biol 1993, 13:841-851.
101. Pertovaara L, Sistonen L, Bos TJ, Vogt PK, Keski-Oja J, Alitato K: enhanced jun gene expression is an early genomic response to trans forming growth factor-stimulation. Mol Cell Biol 1989, 9:1255-1262.
102. Milne DM, Campbell LE, Campbell DG, Meek DW: p53 Is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1. J Biol Chem 1995, 270:5511-5518.
103. Ahlers A, Belka C, Gaestel M, Lamping N, Sott C, Herrmann F, Brach MA: Interleukin-1-induced intracellular signaling pathways converge in the activation of mitogen-activated protein kinase and mitogen-activated protein kinase-activated protein kinase 2 and the subsequent phos phorylation of the 27-kilodalton heat shock protein in monocytic cells. Mol Pharmacol 1994, 46:1077-1083.
104. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young PR: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372:739-746. Identifies p38 and several chemicals that specifically inhibit p38 function.
105. Stokoe D, Campbell DG, Nakielny S, Hidaka H, Leevers SJ, Marshall C, Cohen P : MAPKAP kinase-2: a novel protein kinase activated by mitogen-activated protein kinase. EMBO J 1992, 11:3985-3994.
106. Fuortes M, Jin W-W, Nathan C: Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor. J Cell Biol 1993, 120:777-784.
107. Pulverer BJ, Hughes K, Franklin CC, Kraft AS, Leevers SJ, Woodgett JR: Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukemic cells. Oncogene 1993, 8:407-415.
108. Franklin CC, Unlap T, Adler V, Kraft AS: Multiple signal transduction pathways mediate c-Jun protein phosphorylation. Cell Growth Differ 1993, 4:377-385.
109. Leitman DC, Ribeiro RCJ, Mackrow ER, Baxter JD, West BL: Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor α gene. J Biol Chem 1991, 266:9343-9346.
110. Kolesnick R, Fuks Z: Ceramide: a signal for apoptosis or mitogenesis? J Exp Med 1995, 181:1949-1952. The interaction of tumor necrosis factor-induced cascades and apoptosis may signal through ceramide.
111. Sluss HK, Barrett T, Derijard B, Davis RJ: Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 1994, 14:8376-8384. Tumor necrosis factor activates SAPK/JNK cascades.
112. Reif K, Buday L, Downward J, Cantrell DA: SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases. J Biol Chem 1994, 269:14081-14087.
113. Whitehurst CE, Owaki H, Bruder JT, Rapp UR, Geppert TD: The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells. J Biol Chem 1995, 270:5594-5599.
114. Su B, Jacinot E, Masahiko H, Kallunki T, Karin M, Ben-Neriah: JNK is Involved in signal integration during costimulation of T lymphocytes. Cell 1994, 77:727-736. Interesting article on the MAPK cascades that are activated by costimulation.
115. Whitehurst CE, Boulton TG, Cobb MH, Geppert TD: Extracellular signal-regulated kinases in T cells: anti-CD3 and 4β-phorbol 12-myristate 13-acetate-induced phosphorylation and activation. J Immunol 1992, 148:3230-3237.
116. Hibi M, Lin A, Smeal T, Minden A, Karin M: Identification of an oncoprotein and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993, 7:2135-2148.
117. Alberola J, Forbush KA, Seger R, Krebs EG, Perlmutter RM: Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 1995, 373:620-623. Mitogen-activated protein kinase activation regulates positive selection during thymic ontogeny.
118. Johnson CS, Cook CA, Furmanski P: In vivo suppression of erythropoiesis by tumor necrosis factor-α (TNF-α): reversal with exogenous erythropoietin. Exp Hematol 1990, 18:109-113.
119. Means RT Jr, Dessypris EN, Krantz SB: Inhibition of human colony-forming unit erythroid by tumor necrosis factor requires accessory cells. J Clin Invest 1990, 86:538-541.
120. Johnson RA, Waddelow TA, Caro J, Oliff A, Roodman GD: Chronic exposure to tumor necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 1989, 74:130-138.
121. Smith MA, Knight SM, Maddison PJ, Smith JG: Anemia of chronic disease in rheumatoid arthritis: effect of the blunted response to erythropoietin and of interleukin 1 production by marrow macrophages. Ann Rheum Dis 1992, 51:753-757.
122. Vreugdenhil G, Löwenberg B, Van Eijk HG, Swaak AJG: Tumor necrosis factor alpha is associated with disease activity and the degree of anemia in patients with rheumatoid arthritis. Eur J Clin Invest 1992, 22:488-493.
123. Katevas P, Andonopoulos AP, Kourakli-Symeonidis A, Manopoulou E, Lafi T, Makri M, Zoumbos NC: Peripheral blood mononuclear cells from with rheumatoid arthritis suppress erythropoiesis in vitro via the production of tumor-necrosis factor alpha. Eur J Hematol 1994, 53:26-30.
124. Hooper WC, Jackson D, Pruckler J, Evatt BL: Cellular kinetics of transforming growth factor-beta induced hemoglobin accumulation in the HEL erythroleukemia cell line. Leuk Res 1991, 15:745-751.
125. Francastel C, Mazouri Z, Robert Lezenes J: Co-induction of c-fos and junB during the latent period preceding commitment of Friend erythroleukemia cells to differentiation. Leukemia 1992, 6:935-939.
126. Francastel C, Grisman R, Pfarr CM, Robert-Lezenes J: Antisense c-jun overcomes a differential block in a murine erythroleukemia cell line. Oncogene 1994, 9:1957-1964.
127. Smith MJ, Prochownik EV: Inhibition of c-jun causes reversible proliferation arrest and withdrawal from the cell cycle. Blood 1992, 79:2107-2115.
128. Ritke MK, Rusnak JM, Lazo JS, Allan WP, Dive C, Heer S, Yatowich JC: Differential induction of etoposide-mediated apoptosis in human leukemia HL-60 and K562 cells. Mol Pharmacol 1994, 46:605-611.
129. Owen-Lynch PJ, Wong AKY, Whetton AD: v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation. J Biol Chem 1995, 270:5956-5962.
130. Lee KS, Levin DE: Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog. Mol Cell Biol 1992, 12:172-182.