Dantrolene depolarizes hippocampal neurons in slices from rats

Canadian Journal of Physiology and Pharmacology

Volumn 74, Issue 3, 1996, Pages 241-250

  Krnjevic K ^a,b   Xu, Y Z ^a,c  

^a MCGILL UNIVERSITY   (Canada)

^b McIntyre Building ^*  (Canada)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

Calcium currents and internal stores; Hypoxia; Medium and slow afterhyperpolarization; Q current

Indexed keywords

DANTROLENE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029893097     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y96-014     Document Type: Article

References (45)

1. 2+ stores involved in anoxic responses of hippocampal neurones. J. Physiol. (London), 486: 547-556.
2. Brown, D.A., Gähwiler, B.H., Griffith, W.H., and Halliwell, J.V. 1990. Membrane currents in hippocampal neurones. Prog. Brain Res. 83: 141-160.
3. Constanti, A., and Sim, J.A. 1987. Calcium-dependent potassium conductance in guinea-pig olfactory cortex neurones in vitro. J. Physiol. (London), 387: 173-194.
4. Dubinsky, J.M., and Rothman, S.M. 1991. Intracellular calcium concentrations during chemical hypoxia and excitotoxic neuronal injury. J. Neurosci. 11: 2545-2551.
5. Eckert, R., and Chad, J.E. 1984. Inactivation of Ca channels. Prog. Biophys. Mol. Biol. 44: 215-267.
6. Ellis, K.O., and Bryant, S.H. 1972. Excitation-contraction uncoupling in skeletal muscle by dantrolene sodium. Naunyn-Schmiedeberg's Arch. Pharmacol. 274: 107-109.
7. Erdemli, G., and Krnjević, K. 1994. Actions of cromakalim on outward currents of CA 1 neurones in hippocampal slices. Br. J. Pharmacol. 113: 411-418.
8. Goh, J.W., Sanchez-Vives, H.V., and Pennefather, P.S. 1992. Influence of Na/Ca exchange and mobilization of intracellular calcium on the time course of the slow afterhyperpolarization current (IAHP) in bullfrog sympathetic ganglion neurons. Neurosci. Lett. 138: 123-127.
9. 2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells. J. Physiol. (London), 409: 121-141.
10. Hainaut, K., and Desmedt, J.E. 1974. Effect of dantrolene sodium on calcium movements in single muscle fibres. Nature (London), 252: 728-729.
11. Halliwell, J.V., and Adams, P.R. 1982. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250: 71-92.
12. Hansen, A.J., Hounsgaard, J., and Jahnsen, H. 1982. Anoxia increases potassium conductance in hippocampal nerve cells. Acta Physiol. Scand. 115: 301-310.
13. 2+ in neurons. Neuroscience, 46: 251-273.
14. Kaplin, A.I., Snyder, S.H., and Linden, D.J. 1995. NADH selective stimulation of inositol 1,4,5-trisphosphate receptors mediates hypoxic mobilization of calcium. Soc. Neurosci. Abstr. 21: 1128.
15. Katchman, A.N., and Hershkowitz, N. 1993. Early anoxia-induced vesicular glutamate release results from mobilization of calcium from intracellular stores. J. Neurophysiol. 70: 1-7.
16. Krnjević, K., and Leblond, J. 1989. Changes in membrane currents of hippocampal neurons evoked by brief anoxia. J. Neurophysiol. 62: 15-30.
17. Krnjević, K., and Xu, Y.Z. 1989a. Dantrolene suppresses the hyperpolarization or outward current observed during anoxia in hippocampal neurons. Can. J. Physiol. Pharmacol. 67: 1602-1604.
18. Krnjević, K., and Xu, Y.Z. 1989b. Depolarizing action of dantrolene Na on CA1 hippocampal neurons. Soc. Neurosci. Abstr. 15: 354.
19. Kuba, K. 1980. Release of calcium ions linked to the activation of potassium conductance in a caffeine-treated sympathetic neurone. J. Physiol. (London), 298: 251-269.
20. Lancaster, B., and Adams, P.R. 1986. Calcium-dependent current generating the afterhyperpolarization of hippocampal neurons. J. Neurophysiol. 55: 1268-1282.
21. + current in rat hippocampal neurones. J. Physiol. (London), 475: 229-239.
22. Leblond, J., and Krnjević, K. 1989. Hypoxic changes in hippocampal neurons. J. Neurophysiol. 62: 1-14.
23. 2+ prevents neurotoxicity. Brain Res. 598: 196-202.
24. Maccaferri, G., Mangoni, M., Lazzari, A., and DiFrancesco, D. 1993. Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells. J. Neurophysiol. 69: 2129-2136.
25. 2+. Neuron, 6: 533-545.
26. McCormick, D.A., and Pape, H.C. 1990. Properties of a hyperpolarization-activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J. Physiol. (London), 431: 291-318.
27. 2+ release. Trends Pharmacol. Sci. 16: 356-359.
28. 2+ homeostasis in hippocampal neurons in vitro. Mol. Pharmacol. 35: 671-680.
29. 2+ participate in the afterhyperpolarization of a sympathetic neurone? Brain Res. 268: 158-161.
30. Obenaus, A., Mody, I., and Baimbridge, K.G. 1989. Dantrolene-Na (Dantrium) blocks induction of long-term potentiation in hippocampal slices. Neurosci. Lett. 98: 172-178.
31. O'Mara, S.M., Rowan, M.J., and Anwyl, R. 1995. Dantrolene inhibits long-term depression and depotentiation of synaptic transmission in the dentate gyms of rat hippocampal slices. J. Physiol. (London), 487: 55P-56P.
32. Osmanović, S.S., and Shefner, S.A. 1993. Calcium-activated hyperpolarizations in rat locus coeruleus neurons in vitro. J. Physiol. (London), 469: 89-109.
33. Schwindt, P.C., Spain, W.J., and Crill, W.E. 1992. Effects of intracellular calcium chelation on voltage-dependent and calcium-dependent currents in cat neocortical neurons. Neuroscience, 47: 571-578.
34. i in cultured rat hippocampal neurones following exposure to N-methyl-D-aspartate. J. Physiol. (London), 448: 655-676.
35. Shirasaki, T., Harata, N., and Akaike, N. 1994. Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat. J. Physiol. (London), 475: 439-453.
36. Smith, S.M., and Nahorski, S.R. 1993. Characterization and distribution of inositol polyphosphate and ryanodine receptors in the rat brain. J. Neurochem. 60: 1605-1625.
37. Spain, W.J., Schwindt, P.C., and Crill, W.E. 1987. Anomalous rectification in neurons from cat sensorimotor cortex in vitro. J. Neurophysiol. 57: 1555-1576.
38. Storm, J.F. 1989. An after-hyperpolarization of medium duration in rat hippocampal pyramidal cells. J. Physiol. (London), 409: 171-190.
39. Storm, J.F. 1990. Potassium currents in hippocampal pyramidal cells. Prog. Brain Res. 83: 161-187.
40. Tan, A.T., Erdemli, G., and Krnjević, K. 1995. Metabotropicglutamate receptor activation does not cause anoxic hyperpolarization of hippocampal neurons. Soc. Neurosci. Abstr. 21: 996.
41. + currents that fail to inactivate. Trends Neurosci. 16: 455-460.
42. Van Winkle, W.B. 1976. Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium? Science (Washington, D.C.), 193: 1130-1131.
43. Xu, Y., and Krnjević, K. 1990. Dantrolene does not abolish long-term potentiation of CA1 excitatory postsynaptic potentials in hippocampal slices. Can. J. Physiol. Pharmacol. 68: Axxxv.
44. Yu, S.P., O'Malley, M.D., and Adams, P.R. 1994. Regulation of M current by intracellular calcium in bullfrog sympathetic ganglion neurons. J. Neurosci. 14: 3487-3499.
45. Zhang, L., and Krnjević, K. 1993. Whole-cell recording of anoxic effects on hippocampal neurons in slices. J. Neurophysiol. 69: 118-127.