Investigations on the biotransfomiation of the lipoxygenase inhibitor 2-hydroxy-5-methyl-laurophenone-oxime (FLM 5011);Untersuchungen zur biotransformation des lipoxygenasehemmers 2-hydroxy-5-methyl-laurophenon-oxim (FLM 5011)

Pharmazie

Volumn 51, Issue 6, 1996, Pages 403-409

  Langner, A ^a,c   Rentsch, C ^a   Nerlich, C ^a   Rittner, I ^a   Kuhn H ^a   Schewe, T ^a   Franke, P ^b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXY 5 METHYLLAUROPHENONOXIME; CYTOCHROME P450; DRUG METABOLITE; FLM 5011; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CELL CULTURE; CHEMICAL STRUCTURE; DRUG METABOLISM; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LYMPHOCYTE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT;

ANIMALS; BIOTRANSFORMATION; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; FECES; LAURIC ACIDS; LIPOXYGENASE INHIBITORS; LIVER; LYMPHOCYTES; MALE; MICE; OXIMES; RATS; RATS, WISTAR; TUMOR CELLS, CULTURED;

EID: 0029892806     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Higgs, G. A.; Flower, R. J.; Vane, J. R.: Biochem. Pharmacol. 28, 1959 (1979)
2. Johnson, M.; Carey, F.; McMillan, R. M.: Essays Biochem. 19, 40 (1983)
3. Schewe, T.; Wiesner, R.; Rapoport, S. M.: Meth. Enzymol. 71, 430 (1981)
4. Strasser, M.; Cooper, P.; Dewald, B.; Payne, T.: Helv. Chim. Acta 71, 1156 (1988)
5. Schewe, T.; Kühn, H.; Loose, S.; Lücke, L.; In: Bailey, J. M. (Ed.): Prostaglandins, leukotrienes, lipoxins and PAF, p. 383, New York 1991
6. Seglen, P. O.: Methods Cell Biol. 13, 29 (1976)
7. Melzig, M.: persönliche Mitteilung
8. Langner, A.; Melzig, M.; Kempa, S.; Krause, A.: Pharmazie 50, 130 (1995)
9. Mäder, K.: persönliche Mitteilung
10. Miranda, C. L.: Wang, J. L.: Biochem. Biophys. Res. Commun. 171, 537 (1990)
11. Björkhem, I.; Danielsson, H.: Eur. J. Biochem. 17, 450 (1970)
12. Tatsumi, K.; Ishigai, M.: Arch. Biochem. Biophys. 253, 413 (1987)
13. Andronik-Lion, V.; Boucher, J. L.; Delaforge, M.; Henry, Y.; Mansuy, D.: Biochem. Biophys. Res. Commun. 185, 452 (1992)
14. Sugihara, K.; Tatsumi, K.: Arch. Biochem. Biophys. 247, 289 (1986)
15. Gerondase, P.; Alberti, K. G.; Agius, L.: Biochem. J. 253, 161 (1988)
16. Schewe, T.; Loose, S.; Kühn, H.; Nerlich, C.: Langner, A.; Berger, J.; Lücke, L.: Hoppe-Seyler's Z. Physiol. Chemie 372, 744 (1991)
17. Bednar, M. M.; Schwartzman, M.; Ibraham, N. G.; McGiff, J. C.; Mullane, K. M.: Biochem. Biophys. Res. Commun. 123, 581 (1984)
18. Homa, S. T.; Conroy, D. M.; Smith, A. D.: Prostagl. Leukotr. Med. 14, 417 (1984)