Organization of DNA into foci during replication

Current Opinion in Cell Biology

Volumn 8, Issue 3, 1996, Pages 365-368

  Newport, John ^a   Yan, Hong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STRUCTURAL PROTEIN;

CELL CYCLE S PHASE; CELL NUCLEUS; DNA REPLICATION; DNA STRUCTURE; GENETIC ORGANIZATION; PRIORITY JOURNAL; SHORT SURVEY;

METAZOA;

EID: 0029892697     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(96)80011-1     Document Type: Article

References (17)

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2. Hand R: Eucaryotic DNA: organization of the genome for replication. Cell 1978, 15:317-325.
3. Huberman JA, Riggs AD: On the mechanism of DNA replication in mammalian chromosomes. J Mol Biol 1968, 32:327-341.
4. Planck SR, Mueller GC: Deoxyribonucleic acid chain growth and organization of replicating units in HeLa cells. Biochemistry 1977, 16:1808-1813.
5. Nakamura H, Morita T, Sato C: Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res 1986, 165:291-297.
6. Nakayasu H, Berezney R: Mapping replicational sites in the eukaryotic cell nucleus. J Cell Biol 1989, 108:1-11.
7. Mills AD, Blow JJ, White JG, Amos WB, Wilcock D, Laskey RA: Replication occurs at discrete foci spaced throughout nuclei replicating in vitro. J Cell Sci 1989, 94:471-477.
8. Bravo R, Macdonald-Bravo H: Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 1987, 105:1549-1554.
9. Montecucco A, Savini E, Weighardt F, Rossi R, Ciarrocchi G, Villa A, Biamonti G: The N-terminal domain of human DNA ligase 1 contains the nuclear localization signal and directs the enzyme to sites of DNA replication. EMBO J 1995, 14:5379-5386. Describes the identification of a protein domain which appears to be essential for the association of DNA ligase I with replication foci.
10. Krude T: Chromatin assembly factor 1 (CAF-1) colocalizes with replication foci in HeLa cell nuclei. Exp Cell Res 1995, 220:304-311. Describes the identification of a protein domain required for the association of chromatin assembly factor-1 (CAF-1) with foci.
11. Hoznk P, Jackson DA, Cook PR: Replication factories and nuclear bodies: the ultrastructural characterization of replication sites during the cell cycle. J Cell Biol 1994, 107:2191-2202. A complete microscopic study, at both the electron microscopic and the immunofluorescent level, of foci organization during the S phase of the cell cycle.
12. Hoznk P, Hassan AB, Jackson DA, Cook PR: Visualization of replication factories attached to a nucleoskeleton. Cell 1993, 73:361-373.
13. Leonhardt H, Page AW, Weier H-U, Bestor TH: A targeting sequence directs DNA methyrtransferase to sites of DNA replication in mammalian nuclei. Cell 1992, 71:865-873.
14. Adachi Y, Laemmli UK: Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A. J Cell Biol 1992, 119:1-15.
15. Adachi Y, Laemmli UK: Study of the cell cycle-dependent assembly of the DNA pre-replication enters in Xenopus egg extracts. EMBO J 1994, 13:4153-4164. This paper shows that RPA binds to foci on sperm chromatin incubated in Xenopus egg extracts, and that this association is independent of the kinase activity of Cdk2.
16. Yan H, Newport J: An analysis of the regulation of DNA synthesis by cdk2, Cip1, and licensing factor. J Cell Biol 1995, 129:1-15. The paper describes foci formation and stability during DNA replication in Xenopus egg extracts, and shows that foci formation is independent of the kinase activity of Cdk2.
17. Yan H, Newport J: FFA-1, a protein that promotes the formation of replication centers within nuclei. Science 1995, 269:1883-1885. Describes the use of assays and extracts to identify and purify the protein components which are required to form replication foci.