A novel synthesis of a key intermediate for penems and carbapenems utilizing lipase-catalyzed kinetic resolution

Tetrahedron Asymmetry

Volumn 7, Issue 5, 1996, Pages 1241-1244

  Seki, Masahiko ^a   Furutani, Toshiyuki ^a   Miyake, Tsutomu ^a   Yamanaka, Takeshi ^a   Ohmizu, Hiroshi ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AZETIDINONE DERIVATIVE; CARBAPENEM DERIVATIVE; PENEM DERIVATIVE; TRIACYLGLYCEROL LIPASE;

ARTICLE; CATALYSIS; CHIRALITY; DRUG SYNTHESIS; ENZYME ACTIVITY; PRIORITY JOURNAL; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0029892659     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/0957-4166(96)00132-2     Document Type: Article

References (23)

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13. The X-ray data of compound (±)-6 have been deposited at Cambridge Crystallographic Data Center.
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20. 25 +3.57 (c, 1.23, MeOH). The enantiomeric purity of (2S, 3R)-6 and (2R, 3S)-7 was >99% e.e. which were confirmed by HPLC [Chiralcel OD (Daicel)].
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22. 3)].
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