Point mutation in precore region of hepatitis B virus: Sequential changes from 'wild' to 'mutant'

Journal of Gastroenterology and Hepatology (Australia)

Volumn 11, Issue 6, 1996, Pages 566-574

  Ehata, Toshiki ^a   Yokosuka, Osamu ^a   Imazeki, Fumio ^a   Omata, Masao ^b  

^a CHIBA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Hepatitis B e antigen; Hepatitis B virus; Polymerase chain reaction; Precore

Indexed keywords

HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROCONVERSION;

EID: 0029892578     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.1996.tb01704.x     Document Type: Article

References (29)

1. Tiollais P, Pourcel C, Dejean A. The hepatitis B virus. Nature 1985; 317: 489-95.
2. Uy A, Bruss V, Gerlich WH, Kochel HG, Thomssen R. Precore sequence of hepatitis B virus inducing e antigen and membrane association of the viral core protein. Virology 1986; 155: 89-96.
3. Ou JH, Laub O, Rutter WJ. Hepatitis B virus gene function: The precore region targets the core antigen to cellular membranes and causes the secretion of the e antigen. Proc. Natl Acad. Sci. USA 1986; 83: 1578-82.
4. Schlicht HJ, Salfed J, Schaller H. The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation. J. Virol. 1987; 61: 3701-9.
5. Bruss V, Gerlich WH. Formation of transmembraneous hepatitis B e-antigen by contranslational in vitro processing of the viral precore protein. Virology 1988; 163: 268-75.
6. Chang C, Enders G, Sprengel R, Peters N, Varmus HE, Ganem D. Expression of the precore region of an avian hepatitis B virus is not required for viral replication. J. Virol. 1987; 61: 3322-5.
7. Carman WF, Jacyna AIR, Hadziyannis S et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 1989; ii: 588-91.
8. Okamoto H, Yotsumoto S, Akahane Y et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J. Virol. 1990; 64: 1298-303.
9. Tong S, Li J, Vitvitski L, Trepo C. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region. Virology 1990; 176: 596-603.
10. Brunetto MR, Stemler M, Schodel F et al. Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Ital. J. Gastroenterol. 1989; 21: 151-4.
11. Yokosuka O, Omata M, Imazeki F, Ito Y, Okuda K. Hepatitis B virus RNA transcripts and DNA in chronic liver disease. N. Engl. J. Med. 1986; 315: 1187-92.
12. Bianchi L, De Groote J, Desmet VJ et al. Acute and chronic hepatitis revisited. Lancet 1977; ii: 914-19.
13. Omata M, Afroudakis A, Aschcavai M. Comparison of serum hepatitis B surface antigen (HBsAg) and serum anticore with tissue HBsAg and hepatitis B core antigen (HBcAg). Gastroenterology 1979; 75: 1003-9.
14. Ono Y, Onda H, Sasada R, Igarashi K, Sugino Y, Nishikoka K. The complete nucleotide sequences of the cloned hepatitis B virus DNA: Subtype adr and adw. Nucleic Acids Res. 1983; 11: 1747-57.
15. Saiki RK, Scharf S, Faloona F et al. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 1985; 230: 1350-4.
16. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA 1977; 74: 5463-7.
17. Tada M, Omata M, Ohto M. Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing. Cancer Res. 1990; 50: 1121-4.
18. Matsuyama Y, Omata M, Yokosuka O, Imazeki F, Ito Y, Okuda K. Discordance of hepatitis B e antigen/antibody and hepatitis B virus deoxyribonucleic acid in serum. Analysis of 1063 specimens. Gastroenterology 1985; 89: 1104-8.
19. Hoofnagle JH. Chronic type B hepatitis. Gastroenterology 1983; 84: 422-4.
20. Davis GL, Hoofnagle JH, Waggoner JG. Spontaneous reactivation of chronic hepatitis B virus infection. Gastroenterology 1984; 86: 230-5.
21. Imazeki F, Omata M, Yokosuka O, Matsuyama Y, Ito Y, Okuda K. Analysis of DNA polymerase reaction products for detecting hepatitis B virus in serum: Comparison with spot hybridization technique. Hepatology 1985; 5: 783-8.
22. Hadziyannis SJ, Lieberman HM, Karvountzis GG, Shafritz DA. Analyis of liver disease, nuclear HBcAg, viral replication, and hepatitis B virus DNA in liver and serum of HBeAg vs anti-HBe positive carriers of hepatitis B virus. Hepatology 1983; 3: 656-62.
23. Bonino F, Rosina F, Rizzetto M et al. Chronic hepatitis in HBsAg carriers with serum HBV-DNA and anti-HBe. Gastroenterology 1986; 90: 1268-73.
24. Omata M, Yokosuka O, Imazeki F et al. Correlation of hepatitis B virus DNA and antigens in the liver. Gastroenterology 1987; 92: 192-6.
25. Naoumov NV, Schneider R, Grotzinger T et al. Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 1992; 102: 538-43.
26. Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54 year old woman who contracted the infection through materno-fetal transmission. Jpn J. Exp. Med. 1987; 57: 231-6.
27. Vento S, Hegarty JE, Alberti A et al. T lymphocytes sensitization to HBcAg and T cell-mediated unresponsiveness to HBsAg in hepatitis B virus-related chronic liver disease. Hepatology 1985; 5: 192-7.
28. Schlicht HJ, Schaller H. The secretory core protein of human hepatitis B virus is expressed on the cell surface. J. Virol. 1989; 63: 5399-404.
29. Roossinck MJ, Jameel S, Loukin SH, Siddiqi A. Expression of hepatitis B viral core region in mammalian cells. Mol. Cell Biol. 1986; 6: 1393-400.