Drugs that target gene expression: An overview

Critical Reviews in Eukaryotic Gene Expression

Volumn 6, Issue 1, 1996, Pages 75-85

  Cavalieri, Filippo ^a  

^a Oncogene Science Inc   (United States)

Author keywords

automation; dug discovery; high throughput screening; sickle cell anemia; signal transduction; transcriptional modulation; whole cell assay

Indexed keywords

ANTIESTROGEN; ANTIGESTAGEN; ANTILIPEMIC AGENT; CYCLOSPORIN A; FIBRIC ACID DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; SALICYLIC ACID DERIVATIVE; TACROLIMUS;

ANIMAL CELL; AUTOMATION; DRUG DELIVERY SYSTEM; DRUG SCREENING; ESTROGEN THERAPY; GENE EXPRESSION; GENE TARGETING; GENETIC REGULATION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; TARGET CELL; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0029892436     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v6.i1.50     Document Type: Review

References (82)

1. Barnes PJ, Adcock I (1993): Antiinflammatory actions of steroids: molecular mechanisms. TiPS Rev 14:436-41.
2. Beato M (1989): Gene regulation by steroid hormones. Cell 56:335-44.
3. Beato M (1989): Gene regulation by steroid hormones. Cell 56:335-44.
4. Beaulieu EE (1991): The antisteroid RU486: its cellular and molecular mode of action. Trends Endocrinol Metabol 2:233-9.
5. Berridge MJ (1993): Inositol Tris phosphate and calcium signaling. Nature 361:315-25.
6. Briscoe J, Guschin D, Muller M (1994): Signal transaction. Just another signaling pathway. Curr Biol (England) 4(11):1033-5.
7. Buratowski S (1994): The basics of basal transcription by RNA polymerase II, Cell 77:1-3.
8. Casey PJ (1995): Protein lipidation in cell signalling. Science 268:221-25.
9. Clark EA, Brugge JS (1995): Integrins and transduction pathways: the road taken. Science 268:233-39.
10. Clipstone NA, Crabtree GR (1992): Identification of calcineurin as a key signalling enzyme in T lymphocyte activation. Nature 357:695-7.
11. Dammerman M, Sandkuijl LA, Halaas JL, Chung W, Breslw JL (1993): An apolipoprotein C-III haplotype protective against hypertriglyceridemia is specified by promoter and 3′ untranslated region polymorphism. Proc Natl Acad Sci USA 90:4562-6.
12. Darnell JE, Kerr IM, Stark GR (1994): Jak-STAT pathways and transcriptional activation in response to IFNS and other extracellular signaling proteins. Science 264:1415-21.
13. De La Brousse FC, Mcknight S (1993): Glimpses of allostery in the control of eukaryotic gene expression. TIG 9:5.
14. Drapkin R, Sancar A, Reinberg D (1994): Where transcription meets repair. Cell 77:9-12.
15. Efremov DG, Dimovski AJ, Huisman TH (1994b): The -158 (C to T) promoter mutation is responsible for the increased transcription of the 3′ gamma gene in the Atlanta type of hereditary persistence of fetal hemoglobin. Blood 83(11):3350-55.
16. Efremov DG, Dimovski AJ, Sukarova E, Schiliro G, Zisovski N, Efremov GD, Burrone OR, Huisman TH (1994a): Gamma m-RNA and Hb F levels in beta Thalassemia. Br J Hematol 88(2):311-7.
17. Emmel EA, Verveij CL, Durand DB, Higgins KM, Lacey E, Crabtree GR (1989): Cyclosporin A specifically inhibits the function of nuclear proteins involved in T cell activation. Science 246:1617-20.
18. Evans RM (1988): The steroid and thyroid hormone receptor superfamily. Science 240:889-95.
19. Evans RM (1988): The steroid and thyroid hormone receptor superfamily. Science 240:889-95.
20. Fisher SK (1995): Homologous and heterologous regulation of receptor-stimulated phosphoinositide hydrolysis. Eur J Pharmacol 288(3):231-50.
21. Ghosh A, Greenberg ME (1995): Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268:239-47.
22. Gold MR, Matsuuchi L (1995): Signal transduction by the antigen receptors of B and T lymphocytes. Int Rev Cytol 157:181-276.
23. Green S, Wahli W (1994): Peroxisome proliferator-activated receptors: finding the orphan a home. Mol Cell Endocrinol 100(1-2):149-53.
24. Greenblatt J, Nodwell JR, Mason SW (1993): Transcriptional antitermination. Nature 364:401-6.
25. Hana V, Murphy LJ (1994): Expression of insulin-like growth factors and their binding proteins in the estrogen-responsive Ishikawa human endometrial cancer cell line. Endocrinology (USA) 135(6):2511-16.
26. Hershlag D, Johnson FB (1993): Synergism in transcriptional activation: a kinetic view. Genes Develop 7:173-9.
27. Hertz R, Bishara-Shieban J, Bar-Tana J (1995): Mode of action of peroxisome proliferators as hypolipidemic drugs. J Biol Chem 270(22):13470-75.
28. Ihle JN (1994c): The Janus kinase family and signalling through members of the cytokine receptor superfamily. Proc Soc Exp Biol Med (USA) 206(3):268-72.
29. Ihle JN, Whitthun BA, Quelle FW, Yamamoto K, Thierfelder WE, Kreider B, Sivennoinen O (1994a): Signalling by the cytokine receptor superfamily: Jak and STATs. Trends Biochem Sci (England) 19(5):22-7.
30. Ihle JN, Witthuhn B, Tang B, Yi T, Quelle FW (1994b): Cytokine receptors and signal transduction. Baillieres Clin Hematol (England) 7(1):17-48.
31. Imbra RJ, Karin M (1986): Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature 323:555-7.
32. Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW (1992): Members of the steroid hormone receptor superfamily interact with TFIIB. J Biol Chem 267:617-23.
33. Jones G, Calverley MJ (1993): A dialogue on analogues. Newer Vitamin D drugs for use in bone disease, psoriasis and cancer. TEM 4(9):297-303.
34. Jordan VC (1994): Molecular mechanisms of Antiestrogen action in breast cancer. Breast Cancer Res Treat 31:41-52.
35. Jurivitch DA, Sistonen L, Kroes RA, Morimoto RI (1992): Effect of sodium salicylate on the human heat shock response. Science 255:1243-5.
36. Kaufman RE (1992): Hydroxyurea: specific therapy for sickle cell anemia? Blood 79(10):2503-6.
37. Kim JL, Nikolov DB, Burley SK (1993): Co-crystal structure of TBP recognizing the minor groove of a TATA element. Nature 365:520-27.
38. Kim Y, Geiger JH, Hahn S, Sigler PB (1993): Crystal structure of a yeast TBP/TATA box complex. Nature 365:512-20.
39. Klug A (1993): Opening the gateway. Nature 365:486-7.
40. Kopp E, Ghosh S (1994): Inhibition of NF-Kappa B by sodium salicylate and aspirin. Science 265:956-9.
41. Lalli E, Sassone Corsi P (1993): Signal transduction and gene regulation: the nuclear response to cyclic AMP. J Biol Chem 269(26):17359-62.
42. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL (1991): Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66:807-15.
43. Malamy J, Carr JP, Klessig DF, Raskin I (1990): Salicylic acid: a likely endogenous signal in the resistance response of tobacco to viral infection. Science 250:1002-4.
44. Malarkey K, Belham C/M, Paul A, Graham A, McLees A, Scott PH, Plevin R (1995): The regulation of tyrosine kinase signalling pathways by growth factor and G-protein coupled receptors. Biochem J 309:361-75.
45. Malmendier CL, Lontie J-F, Delcroix C, Dubois DY, Magot T, and De Roy L (1989): Apolipoprotein C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis 77:139-49.
46. Mattila PS, Ullman KS, Fiering S, Emmel EA, McCutcheon M, Crabtree GR, Herzenberg LA (1990): The actions of cyclospoprin A and FK 506 suggest a novel step in the activationof T lymphocytes. EMBO J 9:4425-33.
47. McDonnell DP, Vegeto E, Gleeson MAG (1993): Nuclear hormone receptors as targets for new drug discovery. Bio/Technology 11:1256-61.
48. McDonnell DP, Shahbaz MS, Vegeto E, Goldman ME (1994): The human progesterone receptor A form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. J Steriod Biochem Mol Biol 48:425-32.
49. McDonnell DP (1995): Unraveling the human progeterone receptor signal transduction pathway. TEM 6(4):133-8.
50. McDonnell DP, Clemm DL, Hermann T, Goldman ME, Pike JW (1995): Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. Mol Endocrinol 9(6):659-70.
51. McKay IA, Winyard P, Leigh IM, and Bustin SA (1994): Nuclear transcription factors: potential targets for new modes of intervention in skin disease. Br J Dermatol 131(5):591-7.
52. Mermod N, Williams TJ, Tjian R (1988): Enhanced binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332:557-61.
53. Mochly-Rosen D (1995): Localization of protein kinases by anchoring proteins: a theme in signal transduction. Science 268:247-51.
54. Nadel JA, Borson DB (1991): Modulation of neurogenic inflammation by neutral endopeptidase. Am Rev Respir Dis (USA) 143:833-6.
55. Nishizuka Y (1988): The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 334:6661-5.
56. Nishizuka Y (1995): Protein kinase C and lipid signaling for sustained cellular responses. FASEB 9:484-96.
57. Nishizuka Y (1992): Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-14.
58. O'Keefe S, Tamura J, Kincaid RL, Tocci MJ, O'Neal EA (1992): FK506- and CsA-sensitive activation of the interleukin 2 promoter by calcineurin. Nature 337:692-4.
59. O'Malley BW, Tsai MJ (1992): Molecular Pathways of steroid receptor action. Biol Reprod 46:163-7.
60. Petrij F, Giles RH, Dawerse HG, Saris JJ, Hennekam RCM, Masumo M, Tommerup N, van Omnen G-j B, Goodman RH, Peters DJM, Breuning MH (1995): Rubinstein-Tayibi syndrome caused by mutations in the transcriptional co-activator CBP. Nature 376:348-51.
61. Prashar Y, Khanna A, Sehajpal P, Sharma VK, Suthanthiran M (1995): Stimulation of transforming growth factor beta 1 transcription by cyclosporine. FEBS Lett 358:109-12.
62. Qulliam LA, Khosravi-Far R, Huff SY, Der CJ (1995): Guaninenucleotide exchange factors: activators of the Ras superfamily of proteins. Bioessays 17(5):395-404.
63. Raisford KD (1984): "Aspirin and The Salycylates." London: Butterworths.
64. Rodgers GP (1994): Pharmacologic modulation of fetal hemoglobin. In "Sickle Cell Disease: Basic Principles and Clinical Practice." New York: Raven Press.
65. Sartorius CA, Melville MY, Hovland AR (1994): A third transactivation function (AF3) of human progesterone receptors located in the unique N-terminal segment of the B-isoform. Mol Endocrinol 8:1347-60.
66. Savouret JF, Rauch M, Redeuilh G, Sar S, Chaucherau A, Woodruff K, Parker MG, Milgrom E (1994): Interplay between estrogen, progestins, retinoic acid and AP-1 on a single regulatory site in the progesterone receptor gene. J Biol Chem, 269(46):28955-62.
67. Schonfeld G, Georges PI, Miller J, Reilly P, Witztun J (1979): Apolipoprotein C-II and CII levels in hyperlipoproteinemia. Metabol Clin Exp 28:1001-9.
68. Sen R, Baltimore D (1986): Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46:706-15.
69. Staels B, Vu-dac N, Kosykh VA, Saladin R, Fruchart J-C, Dallongeville J (1995): Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. J Clin Invest 95:705-12.
70. Taniguchi T (1995): Cytokine signaling through nonreceptor protein tyrosine kinases. Science 268:251-57.
71. Thanos D, Maniatis T (1995): NF-kappaB: a lesson in family values. Cell 80:529-32.
72. Tijian R, Maniatis T (1994): Transcriptional activation: a complex puzzle with a few easy pieces. Cell 77:5-8.
73. Tocci MJ, Sigal NH (1992): Recent advances in the mechanism of action of cyclosporine and FK506. Curr Opin Nephrol Hypertens 1:236-42.
74. Ulllman KS, Northrop JP, Verveij CL, Crabtree GR (1990): Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu Rev Immunol 8:421-52.
75. Vane JR, Flower RJ, Bottoing RM (1990): Stroke (Suppl. IV):12.
76. Weber C, Erl W, Pietsch A, Weber PC (1995): Aspirin inhibits nuclear factor kappa B mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation (USA) 91(7):1914-7.
77. Weiss A, Littman DR (1994): Signal transduction by lymphocyte antigen receptors. Cell 76:263-74.
78. Wen DX, Xu Y-F, Mais DE, Goldman ME, McDonnell DP (1994): The A and B isoforms of the human progesteron receptor operate through distinct signalling pathways within target cells. Mol Cell Biol 14:8356-64.
79. Wera S, Belayew A, Martial JA (1995): Rapamycin, CsA and FK-506, inhibit human prolactin gene expression. FEBS Lett 358(2):158-60.
80. Wilks AF, Harpur AG (1994): Cytokine signal transduction and the Jak family of protein Tyrosine kinases. Bioessays (England) 16(5):313-20.
81. Wolffe AP (1994): Transcription: in tune with the histones. Cell 77:13-16.
82. Zitnik RJ, Whiting NL, Elias JA (1994): Glucorticoid inhibition of interleukin-1-induced interleukin-6 production by human lung fibroblasts: evidence for transcriptional and posttranscriptional regulatory mechanisms. Am J Respir Mol Biol 10(6):643-50.