TSG-6, a glycoprotein associated with arthritis, and its ligand hyaluronan exert opposite effects in a murine model of inflammation

Pflugers Archiv European Journal of Physiology

Volumn 431, Issue 6 SUPPL. 2, 1996, Pages

  Wisniewski, Hans Georg ^a   Naime, Dwight ^b   Hua, J C ^a   Vilcek, Jan ^a   Cronstein, Bruce N ^b  

^a Kaplan Cancer Center   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Hyaluronan; Inter inhibitor; Neutrophil infiltration; TSG 6

Indexed keywords

CARRAGEENAN; CYTOKINE; GLYCOPROTEIN; HYALURONIC ACID; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; CELL INFILTRATION; CONFERENCE PAPER; FEMALE; INFLAMMATION; MOUSE; NEGATIVE FEEDBACK; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0029892394     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02346350     Document Type: Conference Paper

References (8)

1. Cronstein BN, Naime D, Ostad E (1993) The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J Clin Invest 92:2675-2682
2. Lee TH, Wisniewski H-G, Vilcek J (1992) A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44. J Cell Biol 116:545-557
3. Maier R, Wisniewski H-G, Vilcek J, Lotz M. TSG-6 expression in human articular chondrocytes: possible implications in joint inflammation and cartilage degradation. submitted
4. Mikecz K, Brennan FR, Kini JH, Giant TT (1995) Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nature Medicine 1:558-563
5. Perretti M, Flower RJ (1993) Modulation of IL-1-induced neutrophil migration by dexamethasone and lipocortin 1. J Immunol 150:992-999
6. Wisniewski H-G, Burgess WH, Oppenheim JD, Vilcek J (1994) TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-α-inhibitor. Biochemistry 33:7423-7429
7. Wisniewski H-G, Hua J-C, Poppers DM, Naime D, Vilcek J, Cronstein BN. The TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-α-inhibitor and exerts a strong antiinflammatory effect in vivo. submitted
8. Wisniewski H-G, Maier R, Lotz M, Lee S, Klampfer L, Lee TH, Vilcek J (1993) TSG-6: a TNF-, IL-I-, and LPS-inducihle secreted glycoprotein associated with arthritis. J Immunol 151:6593-6601