Formulation of a transdermal system for biphasic delivery of testosterone

Journal of Controlled Release

Volumn 39, Issue 1, 1996, Pages 1-7

  Misra, Amit ^a   Raghuvanshi, Rajeev S ^a   Ganga, S ^a   Diwan, Manish ^a   Talwar, G P ^a   Singh, Om ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

In vitro; Pulsatile delivery; Skin permeation; Testosterone; Transdermal delivery

Indexed keywords

2 PROPANOL; POLYVINYL ALCOHOL; POVIDONE; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG FORMULATION; DRUG RELEASE; MALE; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SKIN PENETRATION; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0029892146     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(95)00122-0     Document Type: Article

References (20)

1. W.J. Bremner, M.V. Vitiello and P.M. Prinz, Loss of circadian rhythmicity in blood testosterone levels with aging in normal men, J. Clin. Endocrinol. Metab. 56 (1983) 1278-1281.
2. J.S. Tenover, A.M. Matsumoto, D.K. Clifton and W.J. Bremner, Age related alterations in the circadian rhythm of pulsatile leutenizing hormone and tesosterone secretion in healthy men. J. Gerontol. 43 (1988) M163-169.
3. Testoderm Product Information, Alza Corporation, Palo Alto, CA, USA, 1994.
4. J.S. Finkelstein, R.W. Whitcomb, L. St.L. O'Dea, C. Longcopes, D.A. Schoenfeld and W.F. Crowly, Jr., Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin releasing hormone deficient men, J. Clin. Endocrinol. Metab. 73 (1991) 609-620.
5. Anonymous (World Health Organisation Task Force on Methods for the Regulation of Male Fertility), Contraceptive efficacy of testosterone-induced azoospermia in normal men, Lancet 3 (1990) 955-959.
6. F. Comhaire, Treatment of idiopathic testicular failure with high-dose testosterone undecanoate: A double blind pilot study, Fertil. Steril. 54 (1990) 689-693.
7. J.C. Findlay, V. Place and P.J. Snyder, Treatment of primary hypogonadism in men by the transdermal administration of testosterone, J. Clin. Endocrinol. Metab. 68 (1990) 9-373.
8. V.A. Place, L. Atkinson, D.A. Prather, N. Trunnel and F.E. Yates, Transdermal testosterone replacement through genital skin, in: E. Nieschlag and H.M. Behre (Eds), Testosterone: Action, Deficiency, Substitution, Springer-Verlag, Berlin, 1990, pp. 165-181.
9. W. Lund (Ed.), The Pharmaceutical Codex, 12th Edn, The Pharmaceutical Press, London, 1994, p. 1060.
10. F.F.G. Rommerts, Testosterone: An overview of biosynthesis, transport, metabolism and action, in: E. Nieschlag and H.M. Behre (Eds), Testosterone: Action, Deficiency, Substitution, Springer-Verlag, Berlin, 1990, p. 15.
11. R.H. Guy, J. Hadgraft, R.S. Hinz, K.V. Roskos and D.A.W. Bucks, In vivo evaluations of transdermal drug delivery, in: Y.W. Chien (Ed.), Transdermal Controlled Systemic Medications, Marcel Dekker, New York, 1987, p. 195
12. G. Schaison, K. Nahoul and B. Couzinet, Percutaneous dihydrotestosterone (DHT) treatment, in: E. Nieschlag and H.M. Behre (Eds), Testosterone: Action, Deficiency, Substitution, Springer-Verlag, Berlin, 1990, pp. 155-164.
13. J.L. Zatz and P.P. Sarpotdar, Influence of vehicles on skin penetration, in: A.F. Kydonieus and B. Berner (Eds), Transdermal Delivery of Drugs, Vol. II, CRC Press, Boca Raton, FL, 1987, pp 85-98.
14. A. Misra, O. Singh and G.P. Talwar, Film forming lotion achieves controlled transdermal delivery, Proc. Int. Symp. Control. Release Bioact. Mater. 20 (1993) 414-415.
15. British Pharmacopoeia, Vol. I, HMSO, London, 1988, p. 557.
16. B. Mollgaard and A. Hoelgaard, Permeation of estradiol through the skin - effect of vehicles, Int. J. Pharm. 15 (1983) 185-197.
17. S.B. Sufi, A. Donaldson and S.L. Jeffcoate, WHO matched Reagents Programme Method Manual, 18th Edn, WHO, Geneva, 1994, pp. 74-84.
18. R.C. Wester and H.I. Maibach, Animal models for transdermal delivery, in: A.F. Kydonieus and B. Berner (Eds), Transdermal Delivery of Drugs, Vol. I, CRC Press, Boca Raton, FL, 1987, pp. 61-70.
19. M. Daniel and J.D. Daubisse, The numerical problem of using Bezier curves and surfaces in the power basis, Comput. Aided Geom. Design 6 (1989) 121-128.
20. A. Misra and S.N. Sharma, Pharmaceutical aerosols: packaging and testing, Pharmatimes 20 (1988) 25-29.