Prodrugs of peptides obtained by derivatization of the C-terminal peptide bond in order to effect protection against degradation by carboxypeptidases

International Journal of Pharmaceutics

Volumn 136, Issue 1-2, 1996, Pages 61-69

  Friis, Gitte Juel ^a   Bak, Annette ^a   Larsen, Bjarne Due ^a   Frøkjær, Sven ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

5 Oxazolidinones; Bioreversible derivatization; Carboxypeptidase A; N hydroxyalkylation; Peptide; Prodrug; Stability

Indexed keywords

CARBOXYPEPTIDASE; OXAZOLIDINONE DERIVATIVE; PEPTIDE; PRODRUG;

ALKYLATION; ARTICLE; CHEMICAL BOND; CHEMICAL MODIFICATION; DERIVATIZATION; DRUG DEGRADATION; DRUG STABILITY; HYDROLYSIS; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION;

EID: 0029891922     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04481-7     Document Type: Article

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