Difluoromethylornithine counteracts lesion-induced astrogliosis in rat hippocampus: Enhancement of inhibitory effect by combined treatment with GM1 ganglioside

Acta Neurobiologiae Experimentalis

Volumn 56, Issue 2, 1996, Pages 549-553

  Jegliński, Wojciech ^a   Skup, Małgorzata ^a   Zaremba, Małgorzata ^a   Oderfeld Nowak, Barbara ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

astrogliosis; brain injury; difluoromethylornithine; glial fibrillary acidic protein; GM1 ganglioside; hippocampus; ornithine decarboxylase

Indexed keywords

EFLORNITHINE; GANGLIOSIDE GM1; GLIAL FIBRILLARY ACIDIC PROTEIN; ORNITHINE DECARBOXYLASE;

AMINE TRANSPORT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN INJURY; DRUG EFFECT; DRUG POTENTIATION; ENZYME INHIBITION; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; NONHUMAN; RAT;

ANIMALS; ASTROCYTES; BIOLOGICAL MARKERS; EFLORNITHINE; G(M1) GANGLIOSIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HIPPOCAMPUS; MALE; ORNITHINE DECARBOXYLASE; RATS; RATS, WISTAR;

EID: 0029891747     PISSN: 00651400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Agnati L.F., Fuxe K., Davalli P., Zini T., Corti A., Zoli M. (1985a) Striatal ornithine decarboxylase activity following neurotoxic and mechanical lesions of the mesostriatal dopamine system of the male rat. Acta Physiol. Scand. 125: 173-175
2. Agnati L.F., Fuxe K., Zoli M., Davalli P., Corti A., Zini I., Toffano G. (1985b) Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment. Neurosci. Lett. 61: 339-344
3. Beach T.C., Walker R., Mc Geer E.G. (1989) Patterns of gliosis in Alzheimer's disease and aging cerebrum. Glia 2: 420-436
4. Bell J., Whitmore W.L., Slotkin T.A. (1986) Effects of difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity. Neuroscience 17: 399-407
5. Bradford M. (1976) A rapid and sensitive method for quantitation of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
6. Delacourte A. (1990) General and dramatic glial reaction in Alzheimer brain. Neurology 40: 33-37
7. Hefti F., Dravid A., Hartikka J. (1984) Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septohippocampal lesions. Brain Res. 293: 305-311
8. Jegliński W., Koczyk D., Zaremba M., Oderfeld-Nowak B. (1995) Bilateral gliosis in unilaterally lesioned septohippocampal system: changes in GFAP immunoreactivity and content. J. Neurosci. Res. 41: 394-402
9. Kushner P.D., Stephenson D., Wright S. (1991) Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain. J. Neuropathol. Exp. Neurol. 50: 263-277
10. Laemmli U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
11. Nagy D., Kato T., Kushner P.D. (1994) Reactive astrocytes are widespread in the cortical matter of amyotrophic lateral sclerosis. J. Neurosci. Res. 38: 336-347
12. Norton W.T., Aquino D., Hozumi I., Chiu F.C., Brosnan C.F. (1992) Quantitative aspects of reactive gliosis: a review. Neurochem. Res. 17: 877-885
13. O'Callaghan J.P., Seidler F.J. (1992) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - induced astrogliosis does not require activation of ornithine decarboxylase. Neurosci. Lett. 148: 105-108
14. Oderfeld-Nowak B., Jegliński W., Skup M., Skangiel-Kramska J., Zaremba M., Koczyk D. (1993) Differential effects of GM1 ganglioside treatment on glial fibrillary acidic protein content in the rat septum and hippocampus after partial interruption of their connections. J. Neurochem. 61: 116-119
15. Russel D.H., Snyder S.H. (1968) Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo and various tumors. Proc. Natl. Acad. Sci. USA 60:1420-1427
16. Skup M., Gradkowska M. (1990) Early changes in ornithine decarboxylase activity in a partially denervated hippocampus of rats untreated and treated with GM1 ganglioside. Acta Neurobiol. Exp. 50: 523-532
17. Slotkin T.A., Bartolome J. (1983) Ornithine decarboxylase: marker of neuroendocrine and neurotransmitter actions. In: Methods in enzymology. Academic Press Inc., New York, p. 590 - 603
18. Slotkin T.A., Bartolome J. (1986) Role of ornithine decarboxylase and the polyamines in nervous system development: a review. Brain Res. Bull. 17: 307-320
19. Towbin H.H., Staehlin T., Gordon J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 70: 4350-4354
20. Walsh T., Emerich D.F., Bondy S.C. (1989) Destruction of specific hippocampal cell fields increases ornithine decarboxylase activity; modulation of the biochemical but not histological changes by ganglioside GM1. Exp. Neurol. 105: 54-61
21. Zini I., Zoli M., Agnati L.F., Fuxe K., Merlo-Pich E., Davalli P., Corti A., Gaviolli G., Toffano G. (1986) Studies on the involvement of polyamines for the trophic actions of the ganglioside GM1 in mechanically and 6-hydroxydopamine lesioned rats. Evidence for a permissive role of putrescine. In: Gangliosides and neuronal plasticity (Ed. G. Tettamanti, R.W. Ledeen, K.Sandhoff, Y. Nagai and G. Toffano). Liviana Press - Springer Verlag, Padova, p. 381-396
22. Zini I., Zoli M., Grimaldi R., Merlo-Pich E., Biagini G., Fuxe K., Agnati L.F. (1990) Evidence for a role of neosynthetized putresceine in the increase of glial fibrillary acidc protein immunocytoreactivity induced by a mechanical lesion in the rat brain. Neurosci. Lett. 120: 13-16