The use of dielectric analysis as a means of characterising the effects of moisture uptake by pharmaceutical glyceride bases

International Journal of Pharmaceutics

Volumn 132, Issue 1-2, 1996, Pages 1-8

  Sutananta, Wanchai ^a,b   Craig, Duncan Q M ^a   Newton, J Michael ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b SILPAKORN UNIVERSITY   (Thailand)

Author keywords

Dielectric; Differential scanning calorimetry; Dissolution; Glyceride; Hydration; Viscosity

Indexed keywords

GELUCIRE; MACROGOL STEARATE; THEOPHYLLINE;

ARTICLE; CONTROLLED STUDY; DIELECTRIC CONSTANT; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG DEGRADATION; DRUG RELEASE; DRUG STORAGE; HYDRATION; MOISTURE; PRIORITY JOURNAL; SPECTROSCOPY; VISCOMETRY;

EID: 0029891699     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-5173(95)04226-1     Document Type: Article

References (12)

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2. Dissado, L.A. and Hill, R.M., Anomalous low frequency dispersion: near direct current conductivity in disordered low-dimensional materials. J. Chem. Soc. Faraday Trans. 2, 80 (1984) 291-319.
3. Graham, N.B., In Harris, J.M. (Ed.), Poly(ethylene glycol) Chemistry; Biotechnical and Biomedical Applications, Plenum Press, New York, 1992, pp. 263-281.
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7. Ramdeen, T., Dissado, L.A. and Hill, R.M., The influence of adsorbed water on the dielectric response of a ceramic material. J. Chem. Soc. Faraday Trans. 1, 80 (1984) 325-340.
8. Sutananta, W., Craig, D.Q.M., Hill, R.M. and Newton, J.M., The use of low frequency dielectric spectroscopy as a novel means of investigating the structure of pharmaceutical glyceride bases. Int. J. Pharm., (1995a) in press.
9. Sutananta, W., Craig, D.Q.M. and Newton, J.M., An evaluation of the mechanisms of drug release from glyceride bases. J. Pharm. Pharmacol., 47 (1995b) 182-187.
10. Sutananta, W., Craig, D.Q.M. and Newton, J.M., An investigation into the effects of preparation conditions and storage on the rate of drug release from pharmaceutical bases. J. Pharm. Pharmacol., (1995c) in press.
11. Sutananta, W., Craig, D.Q.M. and Newton, J.M., An investigation into the effect of preparation conditions on the structure and mechanical properties of pharmaceutical glycerides. Int. J. Pharm., 110 (1994a) 75-91.
12. Sutananta, W., Craig, D.Q.M. and Newton, J.M., The effects of ageing on the thermal behaviour and mechanical properties of pharmaceutical glycerides. Int. J. Pharm., 111 (1994b) 51-62.