Identification of Epstein-Barr virus lytic activity in post-transplantation lymphoproliferative disease

Modern Pathology

Volumn 9, Issue 6, 1996, Pages 621-630

  Montone, Kathleen T ^a   Hodinka, Richard L ^b   Salhany, Kevin E ^a   Lavi, Ehud ^a   Rostami, Abdolmohammad ^a   Tomaszewski, John E ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

BZLF1; EBV; EBV early antigens; Immunohistochemistry; In situ hybridization; PTLD

Indexed keywords

ADOLESCENT; ADULT; AGED; ALLOGRAFT; ARTICLE; BONE MARROW TRANSPLANTATION; CHILD; CLINICAL ARTICLE; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFANT; LYMPHOPROLIFERATIVE DISEASE; MALE; ORGAN TRANSPLANTATION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; VIRUS CELL INTERACTION; VIRUS CHARACTERIZATION; VIRUS INFECTION;

ADOLESCENT; ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTIGENS, VIRAL; CHILD; CHILD, PRESCHOOL; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA, VIRAL; DNA-BINDING PROTEINS; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFANT; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; ORGAN TRANSPLANTATION; TRANS-ACTIVATORS; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

EID: 0029891522     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Frizzera G, Hanto DW, Gajl-Peczalalska K, et al.: Polymorphic diffuse B-cell hyperplasias and lymphomas in renal transplant recipients. Cancer Res 41:4262, 1981
2. Hanto DW, Frizzera G, Purtilo DT, et al.: Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res 41:4253, 1981
3. Hanto DW, Gajl-Peczalalska K, Frizzera G, et al.: Epstein-Barr virus induced polyclonal and monoclonal B-cell lymphoproliferative diseases occurring after renal transplantation: Clinical, pathological, and virological findings, and implications for therapy. Ann Surg 198:356, 1983
4. Ho M, Miller G, Atchison RW, et al.: Epstein-Barr virus infections and DNA hybridization studies in posttransplant lymphoma and lymphoproliferative lesions: The role of primary infection. J Infect Dis 152:876, 1985
5. Ho M, Jaffe R, Miller G, et al.: The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation 45:7219, 1988
6. Nalesnik M, Jaffe R, Starzl TE, et al.: The pathology of post-transplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 133:173, 1988
7. Starzl TE, Porter KA, Iwatsuki S, et al.: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet 1:583, 1984
8. Randhawa PS, Jaffe R, Demetris AJ, et al.: Expression of Epstein-Barr virus small RNA (by EBER-1 gene) in liver specimens from transplant recipients with post-transplantation disease. N Engl J Med 137:1710, 1992
9. Montone KT, Friedman H, Hodinka RL, et al.: In situ hybridization for Epstein-Barr virus NotI repeats in posttransplant lymphoproliferative disorder. Mod Pathol 5:292, 1992
10. Wang F, Gregory CD, Rowe M: Epstein-Barr virus nuclear antigen 2 specifically induces expression of the B-cell activation antigen CD23. Proc Natl Acad Sci U S A 84:3452, 1987
11. Purtilo DT, Strobach RS, Okanao M, Davis JR: Epstein-Barr virus-associated lymphoproliferative disorders. Lab Invest 67:5, 1992
12. Crompton CH, Cheung RK, Donjon C, et al.: Epstein-Barr virus surveillance after renal transplantation. Transplantation 57:1182, 1994
13. Marker SC, Ascher NL, Kalis JM, et al.: Epstein-Barr virus antibody responses and clinical illness in renal transplant recipients. Surgery 85:433, 1979
14. Preiksaitis JK, Diaz-Mitoma F, Mirzayans F, Roberts S, Tyrrell DLJ: Quantitative oropharyngeal Epstein-Barr virus shedding in renal and cardiac transplant recipients: Relationship to immunosuppressive therapy, serologic responses, and the risk of posttransplant lymphoproliferative disorder. J Infect Dis 166:986, 1992
15. Savoie A, Perpete C, Carpentier L, Joncas J, Alfieri C: Direct correlation between the load of Epstein-Barr virus infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease. Blood 83: 2715, 1994
16. Sokal EM, Caragiozoglou T, Lamy M, Reding R, Otte JB: Epstein-Barr virus serology and Epstein-Barr virus-associated lymphoproliferative disorders in pediatric liver transplant recipients. Transplantation 56:1394, 1993
17. Strauch B, Siegel N, Andrews L-L, Miller G: Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressive drugs. Lancet 1:234, 1974
18. Jardine DL, Sizeland PCB, Bailey RB, et al.: Epstein-Barr virus infection acquired from a renal transplant. Nephron 58:359, 1991
19. Boyle TJ, Tamburini M, Berend KR, et al.: Human B-cell lymphoma in severe combined immunodeficient mice after active infection with Epstein-Barr virus. Surgery 112:378, 1992
20. Katz BZ, Raab-Traub N, Miller G: Latent and replicating forms of Epstein-Barr virus in lymphomas and lymphoproliferative diseases. J Infect Dis 160:589, 1989
21. Katz BZ, Saini U: Presence of the diffuse early antigen of Epstein-Barr virus in lymphomas and lymphoproliferative disorders. Am J Pathol 140:1247, 1992
22. Montone KT, Hodinka R, Tomaszewski JE: Identification of Epstein-Barr virus lytic and latent transcripts in posttransplant lymphoproliferative disorder. Int J Surg Pathol (in press)
23. Pallesen G, Hamilton D, Rowe M, et al.: Expression of Epstein-Barr virus replicative proteins in AIDS-related non-Hodgkin's lymphoma cells. J Pathol 165:289, 1991
24. Rowe M, Young LS, Crocker J, et al.: Epstein-Barr virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: Implications for the pathogenesis of EBV-positive lymphomas in man. J Exp Med 173:147, 1991
25. Knowles DM, Cesarman E, Chadburn A, et al.: Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplant lymphoproliferative disorder. Blood 85:552, 1995
26. Wang JY, Montone KT: A rapid simple in situ hybridization method for herpes simplex virus employing a synthetic biotin labeled oligonucleotide probe: A comparison with immunohistochemical methods for HSV detection. J Clin Lab Analysis 8:105, 1994
27. Henle W, Henle G: Serodiagnosis of infectious mononucleosis. Resid Staff Physician 37:1981
28. Henle W, Henle G, Horwitz CA: Infectious mononucleosis and Epstein-Barr virus-associated malignancies. In Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections, edited by Lennette EH, Smith Schmidt NJ, Ed 5, p 442. Washington, D.C., American Public Health Association, Inc., 1979
29. Montone KT, Tomaszewski JE: In situ hybridization protocol for detection of overall preservation of mRNA in fixed tissues with a poly d(T) oligonucleotide probe. J Histotechnol 16: 315, 1993
30. Cohen JI: Epstein-Barr virus lymphoproliferative disease associated with acquired immune efficiency. Medicine 70:137, 1991
31. Hamilton-Dutoit SJ, Pallesen: A survey of Epstein-Barr virus gene expression in sporadic non-Hodgkin's lymphomas: Detection of Epstein-Barr virus in a subset of peripheral T-cell lymphomas. Am J Pathol 140:1315, 1992
32. Countryman J, Jenson H, Seibl R, Wolf H, Miller G: Polymorphic proteins encoded within BZLF1 of defective and standard Epstein-Barr viruses disrupt latency. J Virol 61:3672, 1987
33. Rooney CM, Rowe DT, Ragot T, Farrell PJ: The spliced BZLF1 gene of Epstein-Barr virus (EBV) transactivates an EBV promoter and induces the virus productive cycle. J Virol 63:3109, 1989
34. Thomas JA, Hotchin NA, Allday MJ, et al.: Immunohistology of Epstein-Barr virus-associated antigens in B-cell disorders from immunocompromised individuals. Transplantation 49: 944, 1990
35. Henle G, Henle W, Klein G: Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells. Int J Cancer 8:272, 1971
36. Freemer CS, Bertoni G, Takagi S, Sairenji T: A novel early antigen associated with Epstein-Barr virus productive cycle. Virology 194:387, 1993
37. Nuebling CM, Mueller-Lantzch N: Identification and characterization of an Epstein-Barr virus early antigen that is encoded by the NotI repeats. J Virol 63:4609, 1989
38. Nuebling CM, Mueller-Lantzsch N: Identification of the gene product encoded by the PstI. repeats (IR4) of the Epstein-Barr virus genome. Virology 185:519, 1991
39. Montone KT, Budgeon LR, Brigati DJ: Detection of Epstein-Barr virus (EBV) genomes by in situ hybridization with a terminally biotin-labeled synthetic oligonucleotide probe from the EBV Not I and Pst I tandem repeat regions. Mod Pathol 3:89, 1990
40. Ryon JJ, Hayward SD, MacMahon EME, et al.: In situ demonstration of lytic Epstein-Barr virus infection: Expression of the NofI early gene and viral interleukin-10 late gene in clinical specimens. J Infect Dis 168:345, 1993
41. Young LS, Finerty S, Brooks L, et al.: Epstein-Barr virus gene expression in malignant lymphomas induced by experimental virus infection of cottontop tamarins. J Virol 63:1967, 1989
42. Rea D, Delecluse H-J, Hamilton-Dutoit SJ, et al.: Epstein-Barr virus latent and replicative gene expression in post-transplant lymphoproliferative disorders and AIDS-related non-Hodgkin's lymphoma. Ann Oncol 5(Suppl):113, 1994
43. Bashir R, Luka J, Cheloha K, Chamberlain M, Hochberg F: Expression of Epstein-Barr virus proteins in primary CNS lymphoma in AIDS patients. Neurology 43:2358, 1993