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The initial synthesis of Tos-Ser-O-tBu (1) was done by reacting O-t-butyl-N, N′-diisopropylisourea with Tosyl-serine. However, when the reaction was scaled up, separation of side products was more difficult. Mathias, L.J. Synthesis 1979, 561-576.
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8944231854
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note
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Commercially available from Bachern California.
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