Effect of left ventricular pressure and volume overload on α-adrenoceptor activity in patients with rheumatic heart valvular disease

General Pharmacology

Volumn 27, Issue 3, 1996, Pages 539-543

  Dzimiri, Nduna ^a   Moorji, Azadali ^a   Kumar, Mrinalini ^b   Bakr, Soleman ^a   Kumar, Naresh ^b   Almotrefi, Abdulrahman A ^c   Halees, Zohair ^b  

^a Dept of Biol and Medical Research ^*  (Saudi Arabia)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Aortic and mitral regurgitation; Aortic stenosis; Rheumatic heart valvular disease; Adrenoceptors

Indexed keywords

ADRENALIN; ALPHA ADRENERGIC RECEPTOR; CYCLIC AMP; NORADRENALIN; PHENTOLAMINE; RADIOLIGAND; YOHIMBINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CATECHOLAMINE BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISSOCIATION CONSTANT; ELECTROCHEMICAL DETECTION; FEMALE; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIGAND BINDING; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RECEPTOR DENSITY; RHEUMATIC HEART DISEASE; SYMPATHETIC FUNCTION; THROMBOCYTE; VALVULAR HEART DISEASE;

EID: 0029891336     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-3623(95)02030-6     Document Type: Article

References (42)

1. 2-adrenoceptors. Gen. Pharmac. 24, 1-8.
2. Anton A. H. and Sayre D. F. (1962) A study of the factors affecting the aluminium oxide trihydroxyindole procedure for the analysis of catecholamines. J. Pharmac. Exp. Ther. 138, 360-375.
3. Böhm M., Diet F., Feiler G., Kemker B. and Erdmann E. (1988) Alpha-adrenoceptors and α-adrenoceptor-mediated positive inotropic effects in failing human myocardium. J. Cardiovasc. Pharmac. 12, 357-364.
4. m cAMP phosphodiesterase in heart is mediated by a pertussis toxin-sensitive G-protein. J. Biol. Chem. 267, 15496-15501.
5. Bristow M. R. (1993) Changes in myocardial and vascular receptors in heart failure. J. Am. Coll. Cardio. 22, (Suppl), 61A-71A.
6. Bristow M. R., Minok W., Rasmussen R., Hersberger R. F. and Hoffman B. (1988) Alpha-1-adrenergic receptors in nonfailing and failing human heart. J. Pharmac. Exp. Ther. 247, 1039-1045.
7. Brodde O.-E. (1990) Physiology and pharmacology of cardiovascular catecholamine receptors; Implications for treatment of chronic heart failure. Am. Heart J. 120, 1565-1572.
8. 2-adrenergic receptors: Comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol. Pharmac. 42, 1-5.
9. 2-adrenergic receptors. FASEB J. 6, 832-839.
10. Calderone A., Bouvier M., Li K., Juneau C., De Camplain J. and Rouleau J.-L. (1991) Dysfunction of the β- and α-adrenergic systems in a model of congestive heart failure. Circ. Res. 69, 332-343.
11. Clementi E., Malgaretti N., Meldolesi J. and Taramelli R. (1990) A new constitutive activating mutation of the Gs protein α subunit-gsp oncogene is found in human pituitary tumours. Oncogene 5, 1059-1061.
12. Cohn J. N., Levine T. B., Olivari M. T., Garberg V., Lura D., Francis G. S., Simon A. B. and Rector T. (1984) Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. New Engl. J. Med. 311, 819-823.
13. Corr P. B., Shayman J. A., Kramer J. B. and Kipnis R. J. (1982) Increased α-adrenoceptors in ischemic cat myocardium : A potential mediator of electrophysiological derangement. J. Clin. Invest. 67, 1232-1236.
14. Cotecchia S., Kobilka B. K., Daniel K. W., Nolan R. D., Lapetina E. Y., Caron M. G., Lefkowitz R. J. and Regan J. W. (1990) Multiple second messenger pathways of α-adrenergic receptor subtypes expressed in eukaryotic cells. J. Biol. Chem. 265, 63-69.
15. Daly P. A. and Sole M. J. (1990) Myocardial catecholamine and the pathophysiology of heart failure. Circulation 82, I35-I43.
16. Dhalla N. S., Dixon I. M. X. and Beamish R. E. (1991) Biochemical basis of heart function and contractile failure. J. Appl. Cardio. 6, 7-30.
17. Dzimiri N., Kumar M., Moorji A., Prabhakar G. and Duran C. (1995) Effect of left ventricular pressure and volume overload on adrenoceptor activity in patients with left heart valve disease. J. Am. Coll. Cardiol. (abstract, in press).
18. Dzimiri N., Prabhakar G., Moorji A., Bakr S., Halees Z. and Duran C. (1994) Alpha-adrenoceptor activity in patients with rheumatic heart valvular disease. Can. J. Physiol. Pharmac. 72, (Suppl 1), 119.
19. Eschenhagen T. (1993) G protein and the heart. Cell Biol. Internat. 17, 723-749.
20. iα-2 in human end-stage heart failure. Circ. Res. 70, 688-696.
21. Homcy C. J., Vatner S. F. and Vatner D. E. (1991) β-adrenergic receptor regulation in the heart in pathophysiologic states: Abnormal adrenergic responses in cardiac disease. Annu. Rev. Physiol. 53, 137-159.
22. Jackson C. A., Michel M. C. and Insel P. A. (1992) Expression of renal α-adrenergic receptor subtypes in established hypertension. J. Cardiovasc. Pharmac. 19, 857-862.
23. Kumar M., Dzimiri N., Prabhakar G., Bakr S., Moorji A. and Duran C. (1994) Influence of rheumatic heart valvular disease on β-adrenoceptor activity. Can. J. Physiol. Pharmac. 72, (Suppl 1), 119.
24. s and stimulate adenylyl cyclase in human pituitary tumours. Nature 340, 692-696.
25. Lee H. R. (1989) α-Adrenergic receptors in heart failure. Heart Failure 5, 62-70.
26. Leier C. V., Binkley P. F. and Cody R. J. (1990) α-Adrenergic component of the sympathetic nervous system in congestive heart failure. Circulation 82, 168-176.
27. Lomasney J. W., Cotecchia S., Lefkowitz R. J. and Caron M. G. (1991) Molecular biology of α-adrenergic receptors: implications for receptor classification and for structure-function relationships. Biochim. Biophys. Acta 1095, 127-139.
28. Maisel A. S., Motulsky H. J., Ziegler M. G. and Insel P. A. (1987) Ischemia- and agonist induced changes in α- and β-adrenergic receptor traffic in guinea pig heart. Am. J. Physiol. 256, H275-H281.
29. Michel M. C., Philipp T. and Brodde O.-E. (1992) α- and β-adrenoceptor in hypertension: Molecular and pharmacological studies. Pharmac. Toxicol. 70, S1-S10.
30. Prichard B. N. C., Owens C. W. I., Smith C. C. T. and Walden R. J. (1991) Heart and catecholamines. Acta Cardiol. XVLI, 309-322.
31. Ruffolo R. R. and Heible J. P. (1994) α-Adrenoceptors. Pharmac. Ther. 61, 1-8.
32. Ruffolo R. R., Nichols J. M. and Hieble J. P. (1991) Structure and function of α-adrenoceptors. Pharmac. Rev. 43, 475-505.
33. Scholz J., Schafer B., Schmitz W., Scholz H., Steinfath M., Lohse M., Schwabe U. and Puurunen J. (1988) Alpha-1 adrenoceptor-mediated positive inotropic effects and inositol triphosphate increase in mammalian heart. J. Pharmac. Exp. Ther. 245, 327-335.
34. 1-adrenergic response. J. Clin. Invest. 72, 732-738.
35. Spiegel A. L., Shenker A. and Weinstein L. S. (1992) Receptor-effector coupling by G proteins: Implications for normal and abnormal signal transduction. Endocr. Rev. 13, 536-565.
36. 1-Receptor-independent activation of protein kinase C in acute myocardial ischemia. Mechanisms for sensitization of the adenylate cyclase system. Circ. Res. 70, 1304-1312.
37. Summers R. J. and McMartin L. R. (1993) Adrenoceptors and their second messenger systems. J. Neurochem. 60, 10-23.
38. Tsien R. W. (1989) Cyclic AMP and contractile activity in the heart. Adv. Cyclic Nucl. Res. 65, 1417-1425.
39. 1-adrenergic receptors in the failing human heart. Circulation 87, 454-463.
40. 1-adrenergic receptors on sarcolemma from normal subjects and patients with idiopathic dilated cardiomyopathy: Characteristics and linkage to GTP-binding protein. Circ. Res. 64, 474-481.
41. Vatner D. E., Moncy C. J., Sit S. P., Manders T. and Vatner S. F. (1984) Effects of pressure overload, left ventricular hypertrophy on β-adrenergic receptors, and responsiveness to catecholamines. J. Clin. Invest. 73, 1473-1482.
42. Weinstein L. S. and Shenker A. (1993) G protein mutations in human heart. Clin. Biochem. 26, 333-338.