Effects of insulin administration on β-cell function in subjects at high risk for type I diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 45, Issue 7, 1996, Pages 873-875

  Rodriguez Villar C ^a   Conget, I ^a   Gonzalez Clemente J M ^a   Vidal, J ^a   Navarro, P ^a   Casamitjana, R ^a   Gomis, R ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; ISOPHANE INSULIN; PANCREAS ISLET CELL ANTIBODY;

ADOLESCENT; ADULT; ARTICLE; HIGH RISK PATIENT; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; MAJOR CLINICAL STUDY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

EID: 0029891133     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(96)90162-6     Document Type: Article

References (19)

1. Tarn AC, Thomas JM, Dean BM, et al: Predicting insulin dependent diabetes. Lancet 1:845-850, 1988
2. Ziegler AG, Herskowitz RD, Jackson RA, et al: Predicting type 1 diabetes. Diabetes Care 13:762-765, 1990
3. Bonifacio E, Bingley PJ, Shattock M, et al: Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 335:147-149, 1990
4. Riley WJ, Maclaren WK, Krischer J, et al: A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 323:1167-1172, 1990
5. Srikanta S, Ganda OP, Soeldner JS, et al: First-degree relatives of patients with type 1 diabetes mellitus: Islet cell antibodies and abnormal insulin secretion. N Engl J Med 313:451-454, 1985
6. Vardi P, Crisa L, Jackson RA: Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients. Diabetologia 34:93-102, 1991
7. Vlahos WD, Seemayer TA, Yale JF: Diabetes prevention in BB rats by inhibition of endogenous insulin secretion. Metabolism 40:825-829, 1991
8. Atkinson MA, Maclaren NK, Luchetta R: Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 39:933-937, 1990
9. Keller RJ, Eisenbarth GS, Jackson RA: Insulin prophylaxis in individuals at high risk of type 1 diabetes. Lancet 341:927-928, 1993
10. Aaen K, Rygard J, Josenson K, et al: Dependence of antigen expression on functional state of cells. Diabetes 39:697-701, 1990
11. Helderman JH, Pietri AO, Raskin P: In vitro control of T-lymphocyte insulin receptors by in vivo modulation of insulin. Diabetes 32:712-717, 1983
12. Meistas MT, Rendell M, Margolis S, et al: Estimation of the secretion rate of insulin from the urinary excretion rate of C-peptide. Diabetes 31:449-453, 1982
13. Polonsky KS, Rubenstein AH: C-peptide as a measure of the secretion and hepatic extraction of insulin. Review. Diabetes 33:486-494, 1984
14. Tillil H, Shapiro ET, Given BD, et al: Reevaluation of urine C-peptide as measure of insulin secretion. Diabetes 37:1195-1201, 1988
15. Bottazzo GF, Florin-Christensen A, Doniach D: Islet cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2:1279-1283, 1974
16. Yki-Jarvinen H, Koivisto VA: Natural course of insulin resistance in type 1 diabetes. N Engl J Med 315:224-230, 1986
17. DeFronzo RA, Hendler R, Simonson D: Insulin resistance is a prominent feature of insulin-dependent diabetes. Diabetes 31:795-801, 1982
18. Eizirik DL, Strandell E, Sandier S: Prolonged exposure of pancreatic islets isolated from "pre-diabetic" non-obese diabetic mice to a high glucose concentration does not impair beta-cell function. Diabetologia 34:1-5, 1990
19. Hollander PH, Asplin CM, Kniaz D: Beta-cell dysfunction in nondiabetic HLA identical siblings of insulin dependent diabetics. Diabetes 31:149-153, 1982