Down syndrome screening in an Asian population using alpha-fetoprotein and free β-HCG: A report of the Taiwan Down syndrome screening group

Obstetrics and Gynecology

Volumn 87, Issue 6, 1996, Pages 943-947

  Hsu, Jenn J ^a   Hsieh, T'sang T ^b   Hsieh, Fon J ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CHORIONIC GONADOTROPIN BETA SUBUNIT;

ADULT; ARTICLE; BODY WEIGHT; CHINESE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOWN SYNDROME; FEMALE; GENETIC SCREENING; GESTATIONAL AGE; HUMAN; PREGNANCY; PRIORITY JOURNAL; SECOND TRIMESTER PREGNANCY; TAIWAN;

EID: 0029890905     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/0029-7844(96)00042-7     Document Type: Article

References (23)

1. Lin SJ. Down syndrome in Taiwan. Acta Paediatrica Sinica 1994; 35:28-31.
2. Merkatz IR, Nitowsky HM, Macri JN, Johnson WE. An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities. Am J Obstet Gynecol 1984;148:886-91.
3. Hsu JJ, Hsieh TT, Liou JD, Soong YK. Maternal serum and amniotic fluid alpha-fetoprotein in pregnancies with trisomy and other chromosomal abnormalities. J Matern Fetal Invest 1993;3:255-8.
4. Palomaki GE, Knight GJ, Holman MS, Haddow JE. Maternal serum α-fetoprotein screening for fetal Down syndrome in the United States: Results of a survey. Am J Obstet Gynecol 1990;162: 317-21.
5. Crossley JA, Aitken DA, Connor JM. Prenatal screening for chromosome abnormalities using maternal serum chorionic gonadotropin, alpha-fetoprotein, and age. Prenat Diagn 1991;11:83-101.
6. Spencer K, Coombes EJ, Mallard AS, Milford Ward A. Free beta human choriogonadotropin in Down's syndrome screening: A multicentre study of its role compared with other biochemical markers. Ann Clin Biochem 1992;29:506-18.
7. Spencer K. Is the measurement of unconjugated oestriol of value in screening for Down's syndrome. In: Grudzinskas JG, Chard T, Chapman M, Cuckle H, eds. Screening for Down's syndrome. Cambridge, United Kingdom: Cambridge Press, 1994:141-61.
8. Bartels I, Hoppe-Sievert B, Bockel B, Herold S, Caesar J. Adjustment formulae for maternal serum APP, hCG, E3 to maternal weight and smoking. Prenat Diagn 1993;13:123-30.
9. Hsu JJ, Hsieh TT, Lo LM, Soong YK. Midtrimester human chorionic gonadotropin levels: Normal reference values in Chinese pregnant women. Chang Gung Med J 1995;18:240-7.
10. Spencer K. Screening for Down's syndrome. The role of intact hCG and free subunit measurement. Scand J Clin Lab Invest 1993;53: 79-96.
11. Hsu JJ, Chiu TH, Chen KC, Liou JD, Hsieh TT, Soong YK. Maternal serum alpha-fetoprotein levels between 13 and 24 weeks' gestation. Chang Gung Med J 1994;17:309-15.
12. O'Brien JE, Drugan A, Chervenak FA, Johnson MP, Isada NB, Hallak M, et al. Maternal serum alpha-fetoprotein screening: The need to use race/ethnic specific medians in Asians. Fetal Diagn Ther 1993;8:367-70.
13. Spencer K. Evaluation of an assay of the free β-subunit of choriogonadotropin and its potential value in screening for Down's syndrome. Clin Chem 1991;37:809-14.
14. Reynolds TM, Penny MD, Hughes H, John R. The effect of weight correction on risk calculations for Down's syndrome screening. Ann Clin Biochem 1991;28:245-9.
15. Wald NJ, Cuckle HS, Densem JW, Kennard A, Smith D. Maternal serum screening for Down's syndrome: The effect of routine ultrasound determination of gestation age and adjustment for maternal weight. Br J Obstet Gynaecol 1992;99:144-9.
16. Hsieh TT, Lo LM, Hsu JJ, Chiu TH, Liou JD, Hsieh CC, et al. Congenital malformation in newborns: Analysis of 501 cases. Chang Gung Med J 1995;18:14-9.
17. Voigtlander T, Vogel F. Low alpha-fetoprotein and serum albumin levels in Morbus Down may point to a common regulatory mechanism. Human Genetics 1985;71:276-7.
18. IS. Doran TA, Cadesky K, Wong PY, Mastrogiacomo C, Capello T. Maternal serum alpha-fetoprotein and fetal autosomal trisomies. Am J Obstet Gynecol 1986;154:277-81.
19. Cuckle HS, Wald N, Lindenbaum RH. Maternal serum alpha-fetoprotein measurement: Screening test for Down syndrome. Lancet 1984;i:926-9.
20. Spencer K, Carpenter P. Screening for Down's syndrome using serum α-fetoprotein: A retrospective study indicating caution. BMJ 1985;290:1940-3.
21. Macri JN, Kasturi RV, Krantz DA, Cook EJ, Moore NO, Young JA, et al. Maternal serum Down syndrome screening: Free β-protein is a more effective marker than human chorionic gonadotropin. Am J Obstet Gynecol 1990;163:1248-53.
22. Macri JN, Spencer K, Carver K, et al. Maternal serum free beta hCG screening: Results of studies including 480 cases of Down syndrome. Prenat Diagn 1994;14:97-103.
23. Wald N, Densem J, Stone R, Cheng R. The use of free β-hCG in antenatal screening for Down's syndrome. Br J Obstet Gynaecol 1993;100:550-7.