메뉴 건너뛰기




Volumn 66, Issue 6, 1996, Pages 2287-2294

Ras-regulated hypophosphorylation of the retinoblastoma protein mediates neuronal differentiation in PC12 cells

Author keywords

Hypophosphorylation; Nerve growth factor; Neuronal differentiation; PC12 cells; Ras; Retinoblastoma protein

Indexed keywords

CYCLIC AMP; EPIDERMAL GROWTH FACTOR; INTERLEUKIN 6; NERVE GROWTH FACTOR; PHORBOL 13 ACETATE 12 MYRISTATE;

EID: 0029890619     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66062287.x     Document Type: Article
Times cited : (12)

References (43)
  • 1
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 2
    • 0024439444 scopus 로고
    • The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
    • Buchkovich K., Duffy L. A., and Harlow E. (1989) The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58, 1097-1105.
    • (1989) Cell , vol.58 , pp. 1097-1105
    • Buchkovich, K.1    Duffy, L.A.2    Harlow, E.3
  • 3
    • 0024429019 scopus 로고
    • Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
    • Chen P. L., Scully P., Shew J. Y., Wang J. Y., and Lee W. H. (1989) Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58, 1193-1198.
    • (1989) Cell , vol.58 , pp. 1193-1198
    • Chen, P.L.1    Scully, P.2    Shew, J.Y.3    Wang, J.Y.4    Lee, W.H.5
  • 7
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
    • (1976) Proc. Natl. Acad. Sci. USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 8
    • 0027499060 scopus 로고
    • Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
    • Gu W., Schneider J. W., Condorelli G., Kaushal S., Mahdavi V., and Nadal-Ginard B. (1993) Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72, 309-324.
    • (1993) Cell , vol.72 , pp. 309-324
    • Gu, W.1    Schneider, J.W.2    Condorelli, G.3    Kaushal, S.4    Mahdavi, V.5    Nadal-Ginard, B.6
  • 9
    • 0028140163 scopus 로고
    • Different interactions of Grb2/Ash molecule with the NGF and EGF receptors in rat pheochromocytoma PC12 cells
    • Hashimoto Y., Matuoka K., Takenawa T., Muroya K., Hattori S., and Nakamura S. (1994) Different interactions of Grb2/Ash molecule with the NGF and EGF receptors in rat pheochromocytoma PC12 cells. Oncogene 9, 869-875.
    • (1994) Oncogene , vol.9 , pp. 869-875
    • Hashimoto, Y.1    Matuoka, K.2    Takenawa, T.3    Muroya, K.4    Hattori, S.5    Nakamura, S.6
  • 10
    • 0027768579 scopus 로고
    • Braking the cycle
    • Hunter T. (1993) Braking the cycle. Cell 75, 839-841.
    • (1993) Cell , vol.75 , pp. 839-841
    • Hunter, T.1
  • 11
    • 0027938209 scopus 로고
    • Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age
    • Hunter T. and Pines J. (1994) Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79, 573-582.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 13
    • 0027530266 scopus 로고
    • Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells
    • Kalman D., Whittaker K., Bishop J. M., and O'lague P. H. (1993) Domains of E1A that bind p105Rb, p130, and p300 are required to block nerve growth factor-induced neurite growth in PC12 cells. Mol. Biol. Cell 4, 353-361.
    • (1993) Mol. Biol. Cell , vol.4 , pp. 353-361
    • Kalman, D.1    Whittaker, K.2    Bishop, J.M.3    O'Lague, P.H.4
  • 14
    • 0027973043 scopus 로고
    • Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kipl) of cyclin-dependent kinase 4 activation
    • Kato J. Y., Matsuoka M., Polyak K., Massague J., and Sherr C. J. (1994) Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kipl) of cyclin-dependent kinase 4 activation. Cell 79, 487-496.
    • (1994) Cell , vol.79 , pp. 487-496
    • Kato, J.Y.1    Matsuoka, M.2    Polyak, K.3    Massague, J.4    Sherr, C.J.5
  • 15
    • 0026719682 scopus 로고
    • Retinoblastoma gene product activates expression of the human TGF-B2 gene through transcription factor ATF-2
    • Kim S.-J. Wagner S., Liu F., O'Reilly M. A., Robbins P. D., and Green M. R. (1992) Retinoblastoma gene product activates expression of the human TGF-B2 gene through transcription factor ATF-2. Nature 358, 331-334.
    • (1992) Nature , vol.358 , pp. 331-334
    • Kim, S.-J.1    Wagner, S.2    Liu, F.3    O'Reilly, M.A.4    Robbins, P.D.5    Green, M.R.6
  • 16
    • 0027284241 scopus 로고
    • Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1
    • Kiyokawa H., Richon V. M., Venta-Perez G., Rifkind R. A., and Marks P. A. (1993) Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1. Proc. Natl. Acad. Sci. USA 90, 6746-6750.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6746-6750
    • Kiyokawa, H.1    Richon, V.M.2    Venta-Perez, G.3    Rifkind, R.A.4    Marks, P.A.5
  • 17
    • 0028080878 scopus 로고
    • Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells
    • Kiyokawa H., Richon V. M., Rifkind R. A., and Marks P. A. (1994) Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol. Cell. Biol. 14, 7195-7203.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 7195-7203
    • Kiyokawa, H.1    Richon, V.M.2    Rifkind, R.A.3    Marks, P.A.4
  • 18
    • 0027318843 scopus 로고
    • Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-beta
    • Koff A., Ohtsuki M., Polyak K., Roberts J. M., and Massague J. (1993) Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. Science 260, 536-539.
    • (1993) Science , vol.260 , pp. 536-539
    • Koff, A.1    Ohtsuki, M.2    Polyak, K.3    Roberts, J.M.4    Massague, J.5
  • 19
    • 0026744563 scopus 로고
    • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
    • Lee E. Y., Chang C. Y., Hu N., Wang Y. C., Lai C. C., Herrup K., Lee W. H., and Bradley A. (1992) Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 359, 288-294.
    • (1992) Nature , vol.359 , pp. 288-294
    • Lee, E.Y.1    Chang, C.Y.2    Hu, N.3    Wang, Y.C.4    Lai, C.C.5    Herrup, K.6    Lee, W.H.7    Bradley, A.8
  • 20
    • 0028131540 scopus 로고
    • Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
    • Lee E. Y., Hu N., Yuan S. S., Cox L. A., Bradley A., Lee W. H., and Herrup K. (1994) Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 8, 2008-2021.
    • (1994) Genes Dev. , vol.8 , pp. 2008-2021
    • Lee, E.Y.1    Hu, N.2    Yuan, S.S.3    Cox, L.A.4    Bradley, A.5    Lee, W.H.6    Herrup, K.7
  • 22
    • 0026059515 scopus 로고
    • Tumor suppressor genes
    • Marshall C. J. (1991) Tumor suppressor genes. Cell 64, 313-326.
    • (1991) Cell , vol.64 , pp. 313-326
    • Marshall, C.J.1
  • 23
    • 0026581423 scopus 로고
    • Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells
    • Muroya K., Hattori S., and Nakamura S. (1992) Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells. Oncogene 7, 277-281.
    • (1992) Oncogene , vol.7 , pp. 277-281
    • Muroya, K.1    Hattori, S.2    Nakamura, S.3
  • 24
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using expression screening
    • Noda A., Hing Y., Venable S. F., Pereira-Smith O. M., and Smith J. R. (1994) Cloning of senescent cell-derived inhibitors of DNA synthesis using expression screening. Exp. Cell Res. 211, 90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Hing, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 25
    • 0028179669 scopus 로고
    • p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
    • Polyak K., Kato J. Y., Solomon M. J., Sherr C. J., Massague J., Roberts J. M., and Koff A. (1994a) p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8, 9-22.
    • (1994) Genes Dev. , vol.8 , pp. 9-22
    • Polyak, K.1    Kato, J.Y.2    Solomon, M.J.3    Sherr, C.J.4    Massague, J.5    Roberts, J.M.6    Koff, A.7
  • 26
    • 0028176483 scopus 로고
    • Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
    • Polyak K., Lee M. H., Erdjument-Bromage H., Koff A., Roberts J. M., Tempst P., and Massague J. (1994b) Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78, 59-66.
    • (1994) Cell , vol.78 , pp. 59-66
    • Polyak, K.1    Lee, M.H.2    Erdjument-Bromage, H.3    Koff, A.4    Roberts, J.M.5    Tempst, P.6    Massague, J.7
  • 27
    • 0026338953 scopus 로고
    • NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation
    • Qiu M. S. and Green S. H. (1991) NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron 7, 937-946.
    • (1991) Neuron , vol.7 , pp. 937-946
    • Qiu, M.S.1    Green, S.H.2
  • 28
    • 0024465402 scopus 로고
    • Cell cycle-specific action of nerve growth factor in PC12 cells: Differentiation without proliferation
    • Rudkin B. B., Lazarovici P., Levi B. Z., Abe Y., Fujita K., and Guroff G. (1989) Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation. EMBO J. 8, 3319-3325.
    • (1989) EMBO J. , vol.8 , pp. 3319-3325
    • Rudkin, B.B.1    Lazarovici, P.2    Levi, B.Z.3    Abe, Y.4    Fujita, K.5    Guroff, G.6
  • 29
    • 0023476293 scopus 로고
    • Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5′-O-(3-thiotriphosphate)
    • Satoh T., Nakamura S., and Kaziro Y. (1987) Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5′-O-(3-thiotriphosphate). Mol. Cell. Biol. 7, 4553-4556.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 4553-4556
    • Satoh, T.1    Nakamura, S.2    Kaziro, Y.3
  • 30
    • 0028339957 scopus 로고
    • Reversal of terminal differentiation mediated by p107 in Rb-/- Muscle cells
    • Schneider J. W., Gu W., Zhu L., Mahdavi V., and Nadal-Ginard B. (1994) Reversal of terminal differentiation mediated by p107 in Rb-/- muscle cells. Science 264, 1467-1471.
    • (1994) Science , vol.264 , pp. 1467-1471
    • Schneider, J.W.1    Gu, W.2    Zhu, L.3    Mahdavi, V.4    Nadal-Ginard, B.5
  • 31
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr C. J. (1993) Mammalian G1 cyclins. Cell 73, 1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 32
    • 0028986413 scopus 로고
    • A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor
    • Singh P., Coe J., and Hong W. (1995) A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. Nature 374, 562-565.
    • (1995) Nature , vol.374 , pp. 562-565
    • Singh, P.1    Coe, J.2    Hong, W.3
  • 33
    • 0028227197 scopus 로고
    • A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells
    • Slingerland J. M., Hengst L., Pan C. H., Alexander D., Stampfer M. R., and Reed S. I. (1994) A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells. Mol. Cell. Biol. 14, 3683-3694.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3683-3694
    • Slingerland, J.M.1    Hengst, L.2    Pan, C.H.3    Alexander, D.4    Stampfer, M.R.5    Reed, S.I.6
  • 34
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein G. H., Beeson M., and Gordon L. (1990) Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 35
    • 0025075302 scopus 로고
    • Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells
    • Szeberényi J., Cai H., and Cooper G. M. (1990) Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells. Mol. Cell. Biol. 10, 5324-5332.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5324-5332
    • Szeberényi, J.1    Cai, H.2    Cooper, G.M.3
  • 36
    • 0027245610 scopus 로고
    • Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells
    • Tanaka S., Hattori S., Kurata T., Nagashima K., Fukui Y., Nakamura S., and Matsuda M. (1993) Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells. Mol. Cell. Biol. 13, 4409-4415.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4409-4415
    • Tanaka, S.1    Hattori, S.2    Kurata, T.3    Nagashima, K.4    Fukui, Y.5    Nakamura, S.6    Matsuda, M.7
  • 37
    • 0028363519 scopus 로고
    • p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
    • Toyoshima H. and Hunter T. (1994) p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78, 67-74.
    • (1994) Cell , vol.78 , pp. 67-74
    • Toyoshima, H.1    Hunter, T.2
  • 38
    • 0029000724 scopus 로고
    • Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: Superactivation by Rb requires amino acids necessary for growth suppression
    • Udvadia A. J., Templeton D. J., and Horowitz J. M. (1995) Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression. Proc. Natl. Acad. Sci. USA 92, 3953-3957.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3953-3957
    • Udvadia, A.J.1    Templeton, D.J.2    Horowitz, J.M.3
  • 39
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg R. A. (1995) The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 40
    • 0027429964 scopus 로고
    • A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
    • Welch P. J. and Wang J. Y. (1993) A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell 75, 779-790.
    • (1993) Cell , vol.75 , pp. 779-790
    • Welch, P.J.1    Wang, J.Y.2
  • 41
    • 0028802094 scopus 로고
    • Disruption of retinoblastoma protein function by coexpression of its C pocket fragment
    • Welch P. J. and Wang J. Y. (1995) Disruption of retinoblastoma protein function by coexpression of its C pocket fragment. Genes Dev. 9, 31-46.
    • (1995) Genes Dev. , vol.9 , pp. 31-46
    • Welch, P.J.1    Wang, J.Y.2
  • 43
    • 0029052834 scopus 로고
    • NGF regulates the PC12 cell cycle machinery through specific inhibition of the cdk kinases and induction of cyclin D1
    • Yan G. and Ziff E. B. (1995) NGF regulates the PC12 cell cycle machinery through specific inhibition of the cdk kinases and induction of cyclin D1. J. Neurosci. 15, 6200-6212.
    • (1995) J. Neurosci. , vol.15 , pp. 6200-6212
    • Yan, G.1    Ziff, E.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.