The frequency of the haemochromatosis-associated genotype D6S265-1:D6S105-8 in blood donors

British Journal of Haematology

Volumn 93, Issue 4, 1996, Pages 838-840

  Worwood, M ^a   Dorak, M T ^a   Nicklin, S ^a   Stone, C ^b   Pointon, J ^b   Darke, C ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^c National Blood Transfusion Service (Wales)   (United Kingdom)

Author keywords

blood donors; genotype; haemochromatosis; iron; microsatellite markers

Indexed keywords

HLA A3 ANTIGEN; IRON;

ADULT; ARTICLE; BLOOD DONOR; CLINICAL ARTICLE; FEMALE; GENOTYPE; HAPLOTYPE; HEMOCHROMATOSIS; HOMOZYGOSITY; HUMAN; MALE; PRIORITY JOURNAL;

EID: 0029890565     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1732.x     Document Type: Article

References (13)

1. Bothwell, T.H., Charlton, R.W. & Motulsky, A.G. (1989) Hemochromatosis. The Metabolic Basis of Inherited Disease (ed. by C. R. Scriver, A. L. Beuadet, W. S. Sly and D. Valle), pp. 1433-1462. McGraw-Hill, New York.
2. Dacie, J.V. & Lewis, S.M. (1991) Practical Haematology. Churchill Livingstone, Edinburgh.
3. Dorak, M.T., Wilson, D.W.L., Galbraith, I., Henderson, N., Burnett, A.K. & Worwood, M. (1995) A molecular analysis of the telomeric end of the major histocompatibility complex: DNA typing of HLA-A3 subtypes and -B7. Human Immunology, 42, 1-9.
4. Jazwinska, E.C., Lee, S.C., Webb, S.I., Halliday, J.W. & Powell, L. (1993) Localisation of the hemochromatosis gene close to D6S105. American Journal of Human Genetics, 53, 347-352.
5. Jazwinska, E.C., Pyper, W.R., Burt, M.J., Francis, J.L., Goldwurm, S., Webb, S.I., Lee, S.C., Halliday, J.W. & Powell, L. (1995) Haplotype analysis in Australian hemochromatosis patients: evidence for a predominant ancestral haplotype exclusively associated with hemochromatosis. American Journal of Human Genetics, 56, 428-433.
6. Persijn, J-P., van der Slik, W. & Riethorst, A. (1971) Determination of serum iron and latent iron-binding capacity (LIBC). Clinica Chimica Acta, 35, 91-98.
7. Raha-Chowdhury, R., Bowen, D.J., Stone, C., Pointon, J.J., Terwilliger, J.D., Shearman, J.D., Robson, K.J.H., Bomford, A. & Worwood, M. (1995) New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105. Human Molecular Genetics, 4, 1869-1874.
8. Simon, M., Bourel, M., Fauchet, R. & Genetet, B. (1976) Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut, 17, 332-334.
9. Skikne, B., Lynch, S., Borek, D. & Cook, J. (1984) Iron and blood donation. Clinics in Haematology, 13, 271-287.
10. Worwood, M. (1994) Genetics of haemochromatosis. Bailliere's Clinical Haematology, 7, 903-918.
11. Worwood, M. & Darke, C. (1993) Serum ferritin, blood donation, iron stores and haemochromatosis. Transfusion Medicine, 3, 21-28.
12. Worwood, M., Raha-Chowdhury, R. & Darke, C. (1994a) Distribution of alleles at D6S105 and D6S265 with possible HLA haplotype associations. Tissue Antigens, 44, 322-325.
13. Worwood, M., Raha-Chowdhury, R., Dorak, M.T., Darke, C., Bowen, D.J. & Burnett, A.K. (1994b) Alleles at D6S265 and D6S105 define a haemochromatosis-specific genotype. British Journal of Haematology, 86, 863-866.