Pindolol and methylphenidate in children with attention-deficit hyperactivity disorder. Clinical efficacy and side-effects

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 37, Issue 5, 1996, Pages 587-595

  Buitelaar, Jan K ^a,b   Van Der Gaag, Rutger Jan ^a   Swaab Barneveld, Hanna ^a   Kuiper, Marga ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b Department of Child Psychiatry ^*  (Netherlands)

Author keywords

blocker treatment; Attention deficit hyperactivity disorder; Methylphenidate; Pindolol; Side effects

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; METHYLPHENIDATE; PINDOLOL; PSYCHOSTIMULANT AGENT;

ADOLESCENT; ANOREXIA; ANXIETY; ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFICACY; DYSPHORIA; FATIGUE; FEMALE; HALLUCINATION; HEADACHE; HUMAN; INSOMNIA; IRRITABILITY; MAJOR CLINICAL STUDY; MALE; MINIMAL BRAIN DYSFUNCTION; NAUSEA; NIGHTMARE; PARENT; PARESTHESIA; PSYCHOLOGIC TEST; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCHOOL; SOCIAL ISOLATION; SPEECH DISORDER; STOMACH PAIN; TEACHER; TIC;

ADOLESCENT; ADRENERGIC BETA-ANTAGONISTS; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; METHYLPHENIDATE; PERSONALITY ASSESSMENT; PINDOLOL; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 0029889751     PISSN: 00219630     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7610.1996.tb01445.x     Document Type: Article

References (33)

1. Achenbach, T. M. & Edelbrock, C. S. (1983). Manual for the child behavior checklist and revised profile. Burlington, VT: University of Vermont, Department of Psychology.
2. Arnold, L. E. & Aman, M. G. (1991). Beta blockers in mental retardation and developmental disorders. Journal of Child and Adolescent Psychopharmacology, 1, 361-373
3. Bainbridge, J. G. & Greenwood, D. T. (1971). Tranquillizing effects of propranolol demonstrated in rats. Neuropsychopharmacology, 10, 453
4. Barkley, R. A. (1988). Child behavior rating scales and checklists. In M. Rutter, A. H. Tuma, & I. S. Lann (Eds), Assessment and diagnosis in child psychopathology (pp. 113-155). New York: Guilford Press.
5. Barkley, R. A. (1990). Attention deficit hyperactivity disorder: A handbook for diagnosis and treatment. New York: Guildford Press.
6. Biederman, J., Baldessarini, R. J., Wright, V., Knee, D. & Harmatz, J. S. (1989). A double-blind placebo controlled study of desipramine in the treatment of ADD: I. Efficacy. Journal of the American Academy of Child Adolescent Psychiatry, 28, 777-784
7. Blöte, A. W. & Curfs, L. M. G. (1986). Het gebruik van de Conners Teacher Rating Scale in Nederland, Enige psychometrische gegevens. Nederlands Tijdschrift voor de Psychologie, 41, 226-236
8. Cohen, J. (1977). Statistical power analysis for the behavioral sciences. New York: Academic Press.
9. Conners, C. K. (1985a). Teacher questionnaire. Psychopharmacology Bulletin, 21, 823-828
10. Conners, C. K. (1985b). Parent symptom questionnaire. Psychopharmacology Bulletin, 21, 816-822
11. Connor, D. F. (1993). Beta blockers for aggression: A review of the pediatric experience. Journal of Child and Adolescent Psychopharmacology, 3, 99-114
12. Cools, A. R., Van den Bos, R., Ploeger, G. & Ellenbroek, B. A. (1991). Gating function of noradrenaline in the ventral striahim: Its role in behavioural responses to environmental and pharmacological challenges. In P. Willner & J. Scheel-Kruger (Eds.), The mesolimbic dopamine system: From motivation to action (pp. 141-171). New York: John Wiley & Sons.
13. DuPaul, G. J. & Rapport, M. D. (1993). Does methylphenidate normalize the classroom performance of children with attention deficit disorder? Journal of the American Academy of Child Adolescent Psychiatry, 32, 190-198
14. Famularo, R., Kinscherff, R. & Fenton, T. (1988). Propranolol treatment for childhood post traumatic stress disorder, acute type. American Journal of Diseases in Children, 142, 1244-1247
15. Greendyke, P. M. & Kanter, D. R. (1986). Therapeutic effects of pindolol on behavioral disturbances associated with organic brain disease: A double-blind study. Journal of Clinical Psychiatry, 47, 423-426
16. Greenhill, L. L. (1992). Pharmacotherapy: Stimulants. Child and Adolescent Psychiatric Clinics of North America, 1, 411-448
17. Gunning, W. B. (1992). A controlled trial of clonidine in hyperkinetic children. Unpublished thesis, Erasmus University, Rotterdam.
18. Hills, M. & Armitage, P. (1979). The two-period cross-over clinical trial. British Journal of Clinical Pharmacology, 8, 7-20
19. Hunt, R. D., Minderaa, R. B. & Cohen, D. J. (1985). Clonidine benefits children with attention deficit disorder and hyperactivity: Report of a double-blind placebo-crossover therapeutic trial. Journal of the American Academy of Child Psychiatry, 24, 617-629
20. Johnston, C., Pelham, W. E., Hoza, J. & Sturges, J. (1988). Psychostimulant rebound in attention deficit disordered boys. Journal of the American Academy of Child and Adolescent Psychiatry, 27, 806-810
21. Klein, R. G. & Mannuzza, S. (1991). Long-term outcome of hyperactive children: A review. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 383-387
22. Kuperman, S. & Stewart, M. A. (1987). Use of propranolol to decrease aggressive outbursts in younger patients. Psychosomatics, 28, 315-319
23. Neppe, V, M. (1989). Innovative psychopharmacotherapy. New York: Raven Press.
24. NIMH (1985a). CGI (Clinical Global Impression) Scale. Psychopharmacology Bulletin, 21, 839-842
25. NIMH (1985b). DOTES (Dosage Record Treatment Emergent Symptom Scale). Psychopharmacology Bulletin, 21, 1067-1068
26. Rapport, M. D., Denney, C., DuPaul, G. J. & Gardner, M. J. (1994). Attention Deficit Disorder and methylphenidate: Normalizaiton rates, clinical effectiveness, and response prediction in 76 children. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 882-893
27. Sandyk, R., Gillman, M. A., Iacono, R. P. & Bamford, C. R. (1987). Clonidine in neuropsychiatric disorders: A review. International Journal of Neuroscience, 35, 205-215
28. Sims, J. & Galvin, M. R. (1990). Pediatric psychopharmacologic use of propranolol. Journal of Child and Adolescent Psychiatric Mental Health Nursing, 3, 18-24
29. Sverd, J., Cohen, S. & Camp, J. A. (1983). Brief report: Effect of propranolol in Tourette syndrome. Journal of Autism and Developmental Disorders, 13, 207-213
30. Tyrer, P. (1992). Anxiolytics not acting at the benzodiazepine receptor: Beta blockers. Progress in Neuropsychopharmacology and Biological Psychiatry, 16, 17-26
31. Verhulst, F. C., Berden, G. F. M. G. & Sanders-Woudstra, J. A. R. (1985). Mental health in Dutch children: II. The prevalence of psychiatric disorder and relationship between measures. Acta Psychiatrica Scandinavica, 72 suppl. 342,
32. Weinstock, M. & Speizer, Z. (1974). Modification by propranolol and related compounds of motor activity and stereotyped behaviour induced in the rat by amphetamine. European Journal of Pharmacology, 25, 29
33. Williams, D. T., Mehl, R., Yudofsky, S., Adams, D. & Roseman, B. (1982). The effect of propranolol on uncontrolled rage outbursts in children and adolescents with organic brain dysfunction. Journal of the American Academy of Child Psychiatry, 21, 129-135