Aromatase in breast cancer tissue - Localization and relationship with reproductive status of patients

Journal of Cancer Research and Clinical Oncology

Volumn 122, Issue 8, 1996, Pages 495-498

  Berstein, L M ^a   Larionov, A A ^a   Kyshtoobaeva, A Sh ^a   Pozharisski, K M ^a   Semiglazov, V F ^a   Ivanova, O A ^a  

^a N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

Author keywords

aromatase; breast cancer; immunohistochemistry

Indexed keywords

AROMATASE; POLYCLONAL ANTIBODY;

ARTICLE; BREAST CANCER; CONTROLLED STUDY; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; STAINING;

ANIMALS; AROMATASE; BREAST NEOPLASMS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; RABBITS;

EID: 0029889559     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01187162     Document Type: Article

References (22)

1. Adams JB, Li K (1975) Biosynthesis of I7β-oestradiol in human breast carcinoma tissue and a novel method for its characterization. Br J Cancer 31:429-433
2. Berstein L, Larionov A, Kyshtoobaeva A, Pozharisski K, Semiglazov V (1994) The role of cellular substrate in aromatase activity of breast cancer tissue. In: Abstracts of the 1st Baltic Congress on Oncology and Radiology, Tallinn: A54
3. Bezwoda WR, Mansoor N, Esser JD (1987) Aromatization of androstenedione by human breast cancer tissue: correlation with hormone receptor activity and possible biologic significance. Oncology 44:30-33
4. Bolufer P, Ricart E, Lluch AC, Rodriguez A, Ruiz A, Llopis F, Garcia Conde J, Romero R (1992) Aromatase activity and estradiol in human breast cancer: its relationship to estradiol and epidermal growth factor receptors and to tumor-node-metastasis staging. J Clin Oncol 10:438-446
5. Bradlow HL (1982) A reassessment of the role of breast tumor aromatization. Cancer Res 42 [Suppl]:3382s-3386s
6. Esteban JM, Warsi Z, Haniu M, Hall P, Shively JE, Chen S (1992) Detection of intratumoral aromatase in breast carcinomas. Am J Pathol 140:337-343
7. James VHT, McNeill J M, Newton CJ, Ghilchik MV, Reed MJ (1987) Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies. Steroids 50:269-279
8. Landeghem AAJ van, Poortman J, Nabuurs M, Thijssen JHH (1985) Endogenous concentration and subcellular distribution of estrogens in normal and malignant human breast tissue. Cancer Res 45:2900-2905
9. Longcope C (1982) Methods and results of aromatization studies in vivo. Cancer Res 42 [Suppl]:3307s-3311s
10. Lu O, Nakamura J, Savinov A, Brodie A (1995) Evidence of aromatase expression and proliferation in human breast cancers. In: Abstracts of the Endocrine Society (USA) 77th Annual Meeting. Washington, DC: P2-655
11. Miller WR (1991) Aromatase activity in breast tissue. J Steroid Biochem Mol Biol 39:783-790
12. Miller WR, Forrest APM (1976) Oestradiol synthesis from C19 steroids by human breast cancers. Br J Cancer 33:116-118
13. Perel E, Stolle KH, Kharlip L, Blackstein ME, Killinger DW (1984) The intracellular control of aromatase activity by 5α-reduced androgens in human breast carcinoma cells in culture. J Clin Endocrinol Metab 58:467-472
14. Reed MJ, Singh A, Ghilchik MW, Goldham NG, Purohit A (1991) Regulation of oestradiol 17β-hydroxysteroid dehydrogenase in breast tissues: the role of growth factors. J Steroid Biochem Mol Biol 39:791-798
15. Santen RJ, Leszczynski D, Tilson-Mallet N, Feil PD, Wright C, Manni A, Santner SJ (1986) Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways. Ann NY Acad Sci 464:126-137
16. Santen RJ, Martel J, Hoagland M, Naftolin F, Roa L, Harada N, Hafer L, Zaino R, Santner SJ (1994) Stromal spindle cells contain aromatase in human breast tumors. J Clin Endocrinol Metab 79:627-632
17. Sasano N, Nagura H, Harada N, Goukon Y, Kimura M (1994) Immunolocalization of aromatase and other steroidogenic enzymes in human breast disorders. Hum Pathol 25:530-535
18. Siiteri PK (1982) Review of studies on estrogen biosynthesis in the human. Cancer Res 42 [Suppl]:1269s-1273s
19. Silva MC, Rowlands MJ, Dowsett M, Gusterson B, McKinna JA, Fryatt I, Coombes RC (1989) Intra-tumoral aromatase as a prognostic factor in human breast carcinoma. Cancer Res 49:2588-2591
20. Simpson ER, Mendelson CR (1987) Effect of aging and obesity on aromatase activity of human adipose cells. Am J Clin Nutr 45:290-295
21. Varela RM, Dao TL (1978) Estrogen synthesis and estradiol binding by human mammary tumors. Cancer Res 38:2429-2433
22. Vermeulen A, Deslypere J P, Paridaens R, Leclercq G, Roy F, Heuson JC (1986) Aromatase, 17β-hydroxysteroid dehydrogenase and intratissular sex hormone concentrations in cancerous and normal glandular breast tissue in postmenopausal women. Eur J Cancer Clin Oncol 22:515-525