Tubulointerstitial nephritis with renal tubular acidosis and asymptomatic primary biliary cirrhosis accompanied by antibody to a 52-kDa mitochondrial protein alone

Clinical Nephrology

Volumn 45, Issue 6, 1996, Pages 401-405

  Kodama, T ^a   Imai, H ^a   Wakui, H ^a   Ohtani, H ^a   Komatsuda, A ^a   Miura, A B ^a  

^a AKITA UNIVERSITY   (Japan)

Author keywords

Anti mitochondrial antibody; Dihydrolipoamide acyltransferase of the branched chain keto acid dehydrogenase complex; PBC; RTA; Tubulointerstitial nephritis

Indexed keywords

2 OXOACID DEHYDROGENASE; DIHYDROLIPOAMIDE ACETYLTRANSFERASE; IMMUNOGLOBULIN G; MITOCHONDRION ANTIBODY; MULTIENZYME COMPLEX; PROTEIN;

ADULT; AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; ANTIBODY DETECTION; ARTICLE; CASE REPORT; ENZYME IMMUNOASSAY; FEMALE; HUMAN; IMMUNOFLUORESCENCE TEST; INTERSTITIAL NEPHRITIS; KIDNEY BIOPSY; KIDNEY INTERSTITIUM; KIDNEY TUBULE ACIDOSIS; LIVER BIOPSY; LIVER FUNCTION TEST; LYMPHOCYTIC INFILTRATION; MOLECULAR WEIGHT; PRIMARY BILIARY CIRRHOSIS; PROTEIN PURIFICATION; SWINE;

ACIDOSIS, RENAL TUBULAR; ACYLTRANSFERASES; ADULT; AMINO ACID SEQUENCE; AUTOANTIBODIES; BIOPSY; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; HUMANS; IMMUNOBLOTTING; LIVER CIRRHOSIS, BILIARY; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NEPHRITIS, INTERSTITIAL; PEPTIDE FRAGMENTS;

EID: 0029889507     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
2. Cameron JS 1988 Allergic interstitial nephritis: Clinical features and pathogenesis. Q J Med 250: 97-115
3. Fregeau DR, Davis PA, Danner DJ, Ansari A, Coppel RL, Dickson ER, Gershwin ME 1989 Antimitochondrial antibodies of primary biliary cirrhosis recognized dihydrolipoamide acyltransferase and inhibit enzyme function of the branched chain α-ketoacid dehydrogenase complex. J Immunol 142: 3815-3820
4. Gershwin ME, Coppel RL, Mackay IR 1988 Primary biliary cirrhosis and mitochondrial autoantigen - Insights from molecular biology. Hepatology 8: 147-151
5. Gershwin ME, Mackay IR 1991 Primary biliary cirrhosis: Paradigm or paradox for autoimmunity. Gastroenterology 100: 822-833
6. Griffin TA, Chuang DT 1990 Genetic reconstruction and characterization of the recombinant transacylase (E2b) component of bovine branched-chain α keto acid dehydrogenase complex. J Biol Chem 265: 13174-13180
7. Hogeboom GH 1955 Fraction of cell components of animal tissues. Methods in Enzymol 1: 16-19
8. Kamouchi M, Tsuji H, Hirakata H, Okamura K, Ishitsuka T, Murai M, Onoyama K, Fujishima M 1991 Tubulointerstitial disorders in the kidney associated with primary biliary cirrhosis (PBC). Clin Nephrol 35: 134-135
9. Kawasaki H, Emori Y, Suzuki K 1990 Production and separation of peptides from proteins stained with Coomassie brilliant blue R-250 after separation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal Biochem 191: 332-336
10. Krams SM, Surh CD, Coppel RL, Ansari A, Ruebner B, Gershwin ME 1989 Immunization of experimental animals with dihydrolipoamide acetyltransferase, as a purified recombinant polypeptide, generates mitochondrial antibodies but not primary biliary cirrhosis. Hepatology 9: 411-416
11. Laemmli UK 1970 Cleavage of structure proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
12. Lau KS, Chuang JL, Herring WJ, Danner DJ, Cox RP, Chuang DT 1992 The complete cDNA sequence for dihydrolipoyl transacylase (E2) of human branched-chain α-keto acid dehydrogenase complex. Biochemica Biophysica Acta 1132: 319-321
13. Macdougall IC, Isles CG, Whitworth JA, More LAR, MacSween RNM 1987 Interstitial nephritis and primary biliary cirrhosis: A new association? Clin Nephrol 27: 36-40
14. Ohta Y 1993 Subgroup of autoimmune hepatitis/primary biliary cirrhosis. Gastroenterol Jap 28 (Suppl 4): 128-133
15. Pares A, Rimola A, Bruguera M, Mas E, Rodes J 1981 Renal tubular acidosis in primary biliary cirrhosis. Gastroenterology 80: 681-686
16. Pettit FH, Yeaman SJ, Reed LJ 1978 Purification and characterization of branched-chain α-keto acid dehydrogenase complex of bovine kidney. Proc Natl Acad Sci USA 75: 4881-4885
17. Surh CD, Danner DJ, Ahmed A, Coppel RJ, Mackay I, Dickson ER, Gershwin ME 1989 Reactivity of primary biliary cirrhosis sera with a human fetal liver cDNA clone of branched-chain α-keto acid dehydrogenase dihydrolipoamide acyltransferase, the 52 kD mitochondrial autoantigen. Hepatology 9: 63-68
18. Toblli JE, Findor J, Sorda J, Bruch Igartua E, Hasenclever K, Collado HD 1993 Latent distal renal tubular acidosis (dRTA) in primary biliary cirrhosis (PBC) and chronic autoimmune hepatitis (CAH). Acta Gastroenterol Latinoam 23: 235-238
19. Towbin H, Staehelin T, Gordon J 1979 Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications. Proc Natl Acad Sci USA 76: 4350-4354
20. Van de Water J, Cooper A, Surh CD, Coppel R, Donner D, Ansari A, Dickson R, Gershwin ME 1989 Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis. N Engl J Med 320: 1377-1380
21. Van de Water J, Ansari AA, Surh CD, Coppel R, Roche T, Bonkovsky H, Kaplan M, Gershwin ME 1991 Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis. J Immunol 146: 89-94