Anti-agrin staining is absent at abandoned synaptic sites of frog neuromuscular junctions

Journal of Neurobiology

Volumn 30, Issue 2, 1996, Pages 293-302

  Werle, Michael J ^a   Sojka, Anne M ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

AChRs; agrin; in vivo observations; neuromuscular junction; synapse elimination

Indexed keywords

ACETYLCHOLINESTERASE; AGRIN; BUNGAROTOXIN; CHOLINERGIC RECEPTOR; MONOCLONAL ANTIBODY;

ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; FROG; IMMUNOCYTOCHEMISTRY; MALE; NERVE CELL DIFFERENTIATION; NERVE ENDING; NERVE FIBER TRANSECTION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; SYNAPTIC TRANSMISSION;

ACETYLCHOLINESTERASE; AGRIN; ANIMALS; ANTIBODIES, MONOCLONAL; ANURA; BUNGAROTOXINS; IMMUNOHISTOCHEMISTRY; MALE; NEUROMUSCULAR JUNCTION; RECEPTORS, CHOLINERGIC; STAINING AND LABELING; SYNAPSES;

EID: 0029889364     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4695(199606)30:2<293::AID-NEU10>3.0.CO;2-L     Document Type: Article

References (27)

1. BALICE-GORDON, R. J. and LICHTMAN, J. W. (1993). In vivo visualization of pre- and postsynaptic changes during the transition from multiple to single innervation at developing junctions. J. Neurosci. 13:834-855.
2. BALICE-GORDON, R. J. and LICHTMAN, J. W. (1994). Long-term synapse loss induced by focal blockade of postsynaptic receptors. Nature 372:519-524.
3. BIRKS, R., KATZ, B., and MILEDI, R. (1960). Physiological and structural changes at the amphibian myoneural junction in the course of nerve degeneration. J. Physiol. 150:145-168.
4. BOWE, M. A., DEYST, K. A., LESZYK, J. D., and FALLON, J. R. (1994). Identification and purification of an agrin receptor from torpedo postsynaptic membranes: a heteromeric complex related to the dystroglycans. Neuron 12:1173-1180.
5. BRENNER, H. R. and RUDIN, W. (1989). On the effect of muscle activity on the end-plate membrane in denervated mouse muscle. J. Physiol. 410:501-512.
6. CAMPANELLI, J. T., ROBERDS, S. L., CAMPBELL, K. P., and SCHELLER, R. H. (1994). A role for dystrophin-associated glycoproteins and utrophin in agrin-induced AChR clustering. Cell 77:663-674.
7. CHEN, L., FOLSOM, D. B., and Ko, C.-P. (1991). The remodeling of synaptic extracellular matrix and its dynamic relationship with nerve terminals at living frog neuromuscular junctions. J. Neurosci. 11:2920-2930.
8. GEE, S. H., MONTANARO, F., LINDENBAUM, M. H., and CARBONETTO, S. (1994). Dystroglycan-α, a dystrophin associated glycoprotein. is a functional agrin receptor. Cell 77:675-686.
9. GRINNELL, A. D. and Do, J. (1991). Effect of denervation and regeneration on the stability of junctional ACh receptors in mature frog muscles. In: Plasticity of Motoneuronal Connections; Restorative Neurology, Vol. 5, A. Wernig, Ed. Elsevier Science Publishers, New York.
10. HALL, Z. W. and SANES, J. R. (1993). Synaptic structure and development: the neuromuscular junction. Cell. 72(Suppl.):99-121.
11. HERRERA, A. A., BANNER, L. R., and NAGAYA, N. (1990). Repeated, in vivo observation of frog neuromuscular junctions: remodelling involves concurrent growth and retraction. J. Neurocytol. 19:85-99.
12. KARNOVSKY, M. J. and ROOTS, L. (1964). A "directcoloring" thiocholine method for cholinesterases. J. Histochem. Cytochem. 12:219-221.
13. KRAUSE, M. and WERNIG, A. (1985). The distribution of acetylcholine receptors in the normal and denervated neuromuscular junction of the frog. J. Neurocytol. 14:765-780.
14. LETINSKY, M. S., FISCHBECK, K. H., and MCMAHAN, U. J. (1976). Precision of rein nervation of original postsynaptic sites in frog muscle after a nerve crush. J. Neurocytol. 5:691-718.
15. LIU, Y., FIELDS, R. D., FITZGERALD, S., FESTOFF, B. W., and NELSON, P. G. (1994). Proteolytic activity, synapse elimination and the Hebb synapse. J. Neurobiol. 25:325-335.
16. MCMAHAN, U. J. (1990). The agrin hypothesis. Cold Spring Harbor Symp. Quant. Biol. 50:407-418.
17. O'BRIEN, R. A. D., OSTBERG, A. J. C., and VRBOVA, G. (1984). Protease inhibitors reduce the loss of nerve terminals induced by activity and calcium in developing rat soleus muscles in vitro. J. Neurosci. 12:637-646.
18. REDFERN, P. A. (1970). Neuromuscular transmission in new-born rats. J. Physiol. 209:701-709.
19. REIST, N. E., MAGILL, C., and MCMAHAN, U. J. (1987). Agrin molecules at synaptic sites in normal, denervated, and damaged skeletal muscles. J. Cell Biol. 105: 2457-2469.
20. RUPP, F., PAYAN, D. G., MAGILL-SOLC, C., COWAN, D. M., and SCHELLER, R. H. (1991). Structure and expression of a rat agrin. Neuron 6:811-823.
21. SEALOCK, R. and FROEHNER, S. C. (1994). Dystrophin-associated proteins and synapse formation: is α-dystroglycan the agrin receptor? Cell 77:617-619.
22. SMITH, M. A., MAGILL-SOLC, C., RUPP, F., YAO, Y. M., SCHILLING, J. W., SNOW, P., and MCMAHAN, U. J. (1992). Isolation and characterization of an agrin homolog in the marine ray. Mol. Cell. Neurosci. 3:406-417.
23. SUGIYAMA, J., BOWEN, D. C., and HALL, Z. W. (1994). Dystroglycan binds nerve and muscle agrin. Neuron 13:103-115.
24. TSEN, G., HALFTER, W., KROGER, S., and COLE, G. J. (1995). Agrin is a heparan sulfate proteoglycan. J. Biol. Chem. 270:3392-3399.
25. TSIM, K. W. K., RUEGG, M. A., ESCHER, G., KRÖGER, S., and MCMAHAN, U. J. (1992). cDNA that encodes active agrin. Neuron 8:677-689.
26. ++and phorbol ester. J. Cell Biol. 107:267-278.
27. WERNIG, A. and HERRERA, A. A. (1986). Sprouting and remodelling at the nerve-muscle junction. Prog. Neurobiol. 21:251-291.