Sublethal effects of prolonged exposure to disulfoton in rainbow trout (Oncorhynchus mykiss): Cytological alterations in the liver by a potent acetylcholine esterase inhibitor

Ecotoxicology and Environmental Safety

Volumn 34, Issue 1, 1996, Pages 43-55

  Arnold, Helge ^a   Pluta, Hans Jürgen ^b   Braunbeck, Thomas ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Experimental Station Marienfelde   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINESTERASE INHIBITOR; DISULFOTON;

ARTICLE; CYTOLOGY; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; LETHAL DOSE; LIVER METABOLISM; NONHUMAN; ONCORHYNCHUS; PEROXISOME; PROTEIN METABOLISM; RAINBOW TROUT; ROUGH ENDOPLASMIC RETICULUM;

EID: 0029889193     PISSN: 01476513     EISSN: None     Source Type: Journal    
DOI: 10.1006/eesa.1996.0043     Document Type: Article

References (63)

1. Arnold, H., and Braunbeck, T. (1994). Disulfoton as a major toxicant in the chemical spill at Basel in November 1986: Acute and chronic studies with eel and rainbow trout. In Sublethal and Chronic Effects of Pollutants on Freshwater Fish (R. Müller and R. Lloyd, Eds.), pp. 79-86. Blackwell, Oxford.
2. Arnold, H., Pluta, H. J., and Braunbeck, T. (1995a). Simultaneous exposure of fish to endosulfan and disulfoton in vivo: Ultrastructural, stereological and biochemical reactions in hepatocytes of male rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 33, 17-43.
3. Arnold, H., Zahn, T., and Braunbeck, T. (1995b). Sublethal mechanisms of organophosphates in hepatocytes of rainbow trout (Oncorhyuchus mykiss) and European eel (Anguilla anguilla). Verh. Dtsch. Zool. Ges. 88. 1, 252.
4. Benedeczky, I., and Nemcsok, J. (1990). Detection of phenol-induced subcellular alteration by electron microscopy in the liver and pancreas of carp. Environ. Monit. Assess. 14, 385-394.
5. Benedeczky, I., Biro, P., and Schaff, Z. (1984). The effect of 2,4-D-containing herbicide (Dikonirt) on the ultrastructure of carp (Cyprinus carpio) liver cells. Acta Biol. Hung. 30, 107-125.
6. Benedeczky, I., Nemcsok, J., and Halasy, K. (1986). Electron microscopic analysis of the cytopathological effect of pesticides in the liver, kidney and gill tissues of carp. Acta Biol. Szeged 32, 69-91.
7. Bowen, I. D. (1984). Laboratory techniques for demonstrating cell death. In Cell Ageing and Cell Death (I. Davies and D. C. Sigee, Eds.), pp. 5-40. Cambridge Univ. Press, Cambridge, UK.
8. Braunbeck, T. (1993). Cytological alterations in isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) exposed to 4-chloroaniline. Aquat. Toxicol. 25, 83-110.
9. Braunbeck, T. (1994). Detection of environmentally relevant pesticide concentrations using cytological parameters: Pesticide specificity in the reaction of rainbow trout liver? In Sublethal and Chronic Effects of Pollutants on Freshwater Fish. (R. Müller and R. Lloyd, Eds.), pp. 15-29. Blackwell, Oxford.
10. Braunbeck, T., and Völkl, A. (1991). Induction of biotransformation in the liver of eel (Anguilla anguilla L.) by sublethal exposure to dinitro-o-cresol: An ultrastructural and biochemical study. Ecotoxicol. Environ. Saf. 21, 109-127.
11. Braunbeck, T., and Völkl, A. (1993). Toxicant-induced cytological alterations in fish liver as biomarkers of environmental pollution? A case-study on hepatocellular effects of dinitro-o-cresol in golden ide (Leuciscus idus melanotus). In Fish in Ecotoxicology and Ecophysiology (T. Braunbeck, W. Hanke, and H. Segner, Eds.), pp. 55-80. VCH, Weinheim/New York.
12. Braunbeck, T., Gorgas, K., Storch, V., and Völkl, A. (1987). Ultrastructure of hepatocytes in golden ide (Leuciscus idus melanotus L.; Cyprinidae: Teleostei) during thermal adaptation. Anat. Embryol. 175, 303-313.
13. Braunbeck, T., Storch, V., and Nagel, R. (1989). Sex-specific reaction of liver ultrastructure in zebra fish (Brachydanio rerio) after prolonged sublethal exposure to 4-nitrophenol. Aquat. Toxicol. 14, 185-202.
14. Braunbeck, T., Storch, V., and Bresch, H. (1990a). Species-specific reaction of liver ultrastructure of zebra fish (Brachydanio rerio) and trout (Salmo gairdneri) after prolonged exposure to 4-chloroaniline. Arch. Environ. Contam. Toxicol. 19, 405-418.
15. Braunbeck, T., Görge, G., Storch, V., and Nagel, R. (1990b). Hepatic steatosis in zebra fish (Brachydanio rerio) induced by long-term exposure to γ-hexachlorocyclohexane. Ecotoxicol. Environ. Saf. 19, 355-374.
16. Braunbeck, T., Burkhardt-Holm, P., and Storch, V. (1990c). Liver pathology in eel (Anguilla anguilla L.) from the Rhine river exposed to the chemical spill at Basle in November 1986. Limnologie aktuell 1, 371-392.
17. Braunbeck, T., Arnold, H., and Burkhardt-Holm, P. (1994). Subletale Veränderungen bei Fischen durch Pestizide. In Sandoz Rheinfonds-Forschung und Naturschutz (H. Weidmann and H. Meder, Eds.), pp. 60-67. Sandoz International, Basel.
18. Coppage, D. L., and Braidech, T. (1976). River pollution by anticholinesterase agents. Water Res. 10, 19-24.
19. Coppage, D. L., and Matthews, E. (1974). Short-term effects of organophosphate pesticides on cholinesterase of estuarine fishes and pink shrimp. Bull. Environ. Contam. Toxicol. 11, 483-488.
20. Costa, L. G., Shao, M., Basker, K., and Murphy, S. D. (1984). Chronic administration of an organophosphorus insecticide to rats alters cholinergic muscarinic receptors in the pancreas. Chem. Biol. Interact. 48, 261-269.
21. Deutsche Kommission zur Reinhaltung des Rheins (1986). Deutscher Bericht zum Sandoz-Unfall mit Meßprogramm.
22. Dutta, H., Marcelino, J., and Richmonds, C. (1992). Brain acetylcholine esterase activity and optomotor behavior in bluegills, Lepomis macrochirus, exposed to different concentrations of diazinon. Arch. Int. Physiol. Biochim. Biophys. 100, 331-334.
23. Ghadially, F. N. (1988). Ultrastructural Pathology of the Cell and Matrix. Butterworths, London.
24. Gluth, G., and Hanke, W. (1985). A comparison of physiological changes in carp, Cyprinus carpio, induced by several pollutants at sublethal concentrations. Ecotoxicol. Environ. Saf. 9, 179-188.
25. Hajjar, N. P., and Hodgson, E. (1982). Sulfoxidation of thioether-containing pesticides by the flavin-adenine dinucleotide-dependent monooxygenase of pig liver microsomes. Biochem. Pharmacol. 31, 745-752.
26. Hanke, W., Gluth, G., Bubel, H., and Müller, R. (1983). Physiological changes in carps induced by pollution. Ecotoxicol. Environ. Saf. 7, 229-241.
27. Hawkes, J. W. (1980). The effects of xenobiotics on fish tissues: Morphological studies. Fed. Proc. 39, 3230-3236.
28. Heining, P., and Hoffmann, R. W. (1993). Light- and electron microscopical studies on the prolonged toxicity of trichlorethylene on rainbow trout (Oncorhynchus mykiss). Exp. Toxicol. Pathol. 45, 167-176.
29. Hinton, D. E., Couch, J. A., Teh, S. J., and Courtney, L. A. (1988). Cytological changes during progression of neoplasia in selected fish species. Aquat. Toxicol. 11, 77-112.
30. Hodgson, E. (1982). Production of pesticide metabolites by oxidative reactions. J. Toxicol. Clin. Toxicol. 19, 609-621.
31. Holcombe, G. W., Phipps, G. L., and Tanner, D. K. (1982). The acute toxicity of kelthane, dursban, disulfoton, pyridin and permethrin to fathead minnows, Pimephales promelas, and rainbow trout, Salmo gairdneri. Environ. Pollut. 29, 167-178.
32. Howard, P. H. (1991). Handbook of Environmental Fate and Exposure Data for Organic Chemicals. Vol. III, pp. 309-318. Lewis, Michigan.
33. Ingelman-Sundberg, M. (1980). Bioactivation or inactivation of toxic compounds. Tips 2, 176-179.
34. Karnovsky, M. J. (1971). Use of ferrocyanide-reduced osmium tetroxide in electron microscopy. J. Cell Biol. 51, 146A.
35. Klaunig, J. E., Lipsky, M. M., Trump, B. F., and Hinton, D. E. (1979). Biochemical and ultrastructural changes in teleost liver following sub-acute exposure to PCB. J. Environ. Pathol. Toxicol. 2, 953-963.
36. Le Hir, M., Herzog, V., and Fahimi, H. D. (1979). Cytochemical detection of catalase with 3,3′-diaminobenzidine. A quantitative reinvestigation of the optimal assay conditions. Histochemistry 64, 51-66.
37. Lester, S. M., Braunbeck, T., Teh, S. J., Stegeman, J. J., Miller, M. R., and Hinton, D. E. (1993). Hepatic cellular distribution of cytochrome CYP 1A in rainbow trout (Oncorhynchus mykiss): An immunohisto- and cytochemical study. Cancer Res. 53, 3700-3706.
38. Levi, P. E., Hollingworth, R. M., and Hodgson, E. (1988). Differences in oxidative dearylation and desulfuration of fenitrothion by cytochrome P-450 isoenzymes and in the subsequent inhibition of monooxygenase activity. Pestic. Biochem. Physiol. 32, 224-231.
39. Lindström-Seppä, P., Koivusaari, U., and Hänninen, O. (1981). Extrahepatic xenobiotic metabolism in North-European freshwater fish. Comp. Biochem. Physiol. 69, 259-263.
40. Mayer, F. L., and Ellersieck, M. R. (1986). Manual of Acute Toxicity: Interpretation and Data Base for 410 Chemicals and 66 Species of Freshwater Animals. U.S. Department of the International Fish and Wildlife Service Research Publication 160.
41. Rajasekaran, A. K., Morimoto, T., Hanzel, D. K., Rodriguez-Boulan, E., and Kreibich, G. (1993). Structural reorganization of the rough endoplasmic reticulum without size expansion accounts for dexamethasone-induced secretory activity in AR42J cells. J. Cell Sci. 105, 333-345.
42. Reynolds, E. S. (1963). The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208-212.
43. Richardson, K. C., Jarett, L., and Finke, E. H. (1960). Embedding in epoxy resins for ultrathin sectioning in electron microscopy. Stain Technol. 35, 313-323.
44. Schlenk, D., and Buhler, D. R. (1991a). Flavin-containing monooxygenase activity in liver microsomes from rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 20, 13-24.
45. Schlenk, D., and Buhler, D. R. (1991b). Role of flavin-containing monooxygenase in the in vitro biotransformation of aldicarb in rainbow trout (Oncorhynchus mykiss). Xenobiotica 21, 1583-1589.
46. Schoor, W. P., and Couch, J. A. (1979). Correlation of mixed-function activity with ultrastructural changes in the liver of a marine fish. Cancer Biochem. Biophys. 4, 95-103.
47. Schwab, B.W., Costa, L. G., and Murphy, S. D. (1983). Muscarinic receptor alterations as a mechanism of anticholinesterase tolerance. Toxicol. Appl. Pharmacol. 71, 14-23.
48. Segner, H. (1985). Influence of starvation and refeeding with different diets on the hepatocyte ultrastructure of juvenile Siganus guttatus Bloch (Teleostei: Siganidae). Zool. Anz. 214, 81-90.
49. Segner, H., and Braunbeck, T. (1990). Adaptive changes of liver composition and structure in golden ide during winter acclimatization. J. Exp. Zool. 255, 171-185.
50. Singh, I. (1964). A modification of the Masson-Hamperl method for staining of argentaffin cells. Anat. Anz. 115, 81-82.
51. Smolowitz, R. M., Hahn, M. E., and Stegeman, J. J. (1991). Immunohistochemical localization of cytochrome P-450IA1 induced by 3,3,4,4-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzoafuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (Scup). Drug Metab. Dispos. 19, 113-123.
52. Spurr, A. R. (1969). A low viscosity embedding medium for electron microscopy. J. Ultrastruct. Res. 26, 31-43.
53. Takase, I., and Oyama, H. (1985). Uptake and bioconcentration of disulfoton and its oxidation compounds in carp, Cyprinus carpio L. J. Pestic. Sci. 10, 47-54.
54. Weibel, E. R. (1979). Stereological Methods. Vol. I. Academic Press, New York.
55. Weibel, E. R., Stäubli, W., Gnägi, H. R., and Hess, F. A. (1969). Correlated morphometric and biochemical studies on the liver cell. I. Morphometric model, stereologic methods, and normal morphometric data for rat liver. J. Cell Biol. 42, 68-91.
56. World Health Organization (WHO) (1986). Organophosphorus pesticides: A general introduction. In Environmental Health Criteria, Vol. 63. WHO, Geneva.
57. Wyllie, A. H., Duvall, E., and Blow, J. J. (1984). Intracellular mechanisms in cell death in normal and pathological tissues. In Cell Ageing and Cell Death (I. Davies and D. C. Sigee, Eds.), pp. 269-294. Cambridge Univ. Press, Cambridge, UK.
58. Yamamoto, M., and Egami, N. (1974). Sexual differences and age changes in the fine structure of hepatocytes in the medaka, Oryzias latipes. J. Fac. Sci. Univ. Tokio, Sec. IV 13, 199-210.
59. Zahn, T., and Braunbeck, T. (1993). Isolated fish hepatocytes as a tool in aquatic toxicology - Sublethal effects of dinitro-o-cresol and 2,4-dichlorophenol. Sci. Total Environ. (Suppl. 1993), 721-734.
60. Zahn, T., and Braunbeck, T. (1995). Acute and sublethal toxicity of seepage water from garbage dumps to permanent cell cultures and primary cultures of hepatocytes from rainbow trout (Oncorhynchus mykiss): A novel approach to environmental risk assessment for chemicals and chemical mixtures. Zbl. Hyg. 196, 455-479.
61. Zahn, T., Hauck, C., and Braunbeck, T. (1993). Cytological alterations in fish fibrocytic R1 cells as an alternative test system for the detection of sublethal effects of environmental pollutants: A case-study with 4-chloroaniline. In Fish in Ecotoxicology and Ecophysiology (T. Braunbeck, W. Hanke, and H. Segner, Eds.), pp. 103-126. VCH, Weinheim/New York.
62. Zahn, T., Arnold, H., and Braunbeck, T. (1996). Cytological and biochemical response of R1 cells and isolated hepatocytes from rainbow trout (Oncorhynchus mykiss) to subacute in vitro exposure to disulfoton. Exp. Toxicol. Pathol. 48, 47-64.
63. Zepp, R. G., Baughman, G. L., and Schlotzhauer, P. (1981). Comparison of photochemical behaviour of various humic substances in water: I. Sunlight-induced reactions of aquatic pollutants photosensitized by humic substances. Chemosphere 10, 109-117.