Oxidative injury to isolated rat pancreatic acinar cells vs. isolated zymogen granules

Free Radical Biology and Medicine

Volumn 20, Issue 7, 1996, Pages 877-886

  Niederau, Claus ^a   Klonowski, Hanne ^b   Schulz, Hans Ulrich ^b   Sarbia, Mario ^b   Lüthen, Reinhard ^b   Häussinger, Dieter ^b  

^a Division of Gastroenterology   (Germany)

^b NONE

Author keywords

Acute pancreatitis; ATP; Autodigestion; Free radicals; Mitochondria; Oxidative stress; Trypsin; Zymogen granules

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMYLASE; CERULETIDE; DEOXYRIBOSE; FREE RADICAL; HYPOXANTHINE; IRON CHELATE; TRYPSIN; TRYPSINOGEN; XANTHINE OXIDASE; ZYMOGEN GRANULE;

ACINAR CELL; ACUTE PANCREATITIS; AMYLASE RELEASE; ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL FUNCTION; CELL ORGANELLE; CELL VACUOLE; CELL VIABILITY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

EID: 0029889032     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(95)02153-1     Document Type: Article

References (35)

1. Braganza, J. M. Free radicals and pancreatitis. In: Rice-Evans, C.; Dormandy, T., eds. Free radicals: Chemistry, pathology, and medicine. London: Richelieu Press; 1988:357-381.
2. Schönberg, M. H.; Büchler, M.; Beger, H. G. Oxygen radicals in experimental acute pancreatitis. Hepato-Gastroenterology 41:313-319; 1994.
3. Niederau, C.; Schulz, H, U.; Letko, G. Involvement of free radicals in the pathophysiology of chronic pancreatitis: potential of treatment with antioxidant and scavenger substances. Klin. Wochenschr. 69:1018-1024; 1991.
4. Uden, S.; Bilton, D.; Nathan, L.; Hunt, L. P.; Main, C.; Braganza, J. M. Antioxidant therapy for recurrent pancreatitis: placebo-controlled trial. Aliment. Pharmacol. Ther. 4:357-371; 1990.
5. Guyan, P. M.; Braganza, J. M.; Butler, J. The effect of oxygen metabolites on the zymogens of human pancreatic proteases. In: Rice-Evans, C.; Dormandy, T., eds. Free radicals: Chemistry, pathology and medicine. London: Richelieu Press; 1988:471-474.
6. Niederau, C.; Rothmann, S. S.; Grendell, J. H. Characteristics of rat pancreatic zymogen granules prepared by different methods. Am. J. Physiol. 251:G421-G429; 1986.
7. De Lisle, R. C.; Schulz, I.; Tyrakowski, T.; Hasse, W.; Hopfer, U. Isolation of stable pancreatic zymogen granules. Am. J. Physiol. 246:G411-G418; 1984.
8. Niederau, C.; Van Dyke, R. W.; Scharschmidt, B. F.; Grendell, J. H. Rat pancreatic zymogen granules: an actively acidified compartment. Gastroenterology 91:1433-1442; 1986.
9. + pump activity in pancreatic acinar cells. Am. J. Physiol. 245:G339-G346; 1983.
10. Klonowski, H.; Schulz, H. U.; Niederau, C. Mechanisms of free radical induced damage to pancreatic acinar cells. Digestion 54:A286; 1993.
11. Lowry, O. H.; Rosebrough, N. J.; Farr, A. L.; Randall, R. J. Protein measurements with Folin phenol reagent. J. Biol. Chem. 193:265-275; 1951.
12. Niederau, C.; Ferrell, L. D.; Grendell, J. H. Caerulein-induced acute necrotizing pancreatitis in mice: Protective effects of proglumide, benzotript, and secretin. Gastroenterology 88:1192-1204; 1985.
13. Labarca, C.; Paigen, K. A simple, rapid, and sensitive DNA assay procedure. Ana. Biochem. 102:344-352; 1990.
14. Halliwell, B.; Gutteridge, J. M. C. Formation of thiobarbituric acid-reactive substance from deoxyribose in the presence of iron salts - The role of superoxide and hydroxyl radicals. FEBS Lett. 128:347-351; 1981.
15. Kvietys, P. R.; Inauen, W.; Bacon, B. R.; Grisham, M. B. Xanthine oxidase-induced injury to endothelium: Role of intracellular iron and hydroxyl radical. Am. J. Physiol. 257:H1640-H1646; 1989.
16. Winterbourn, C. C. Factors that influence the deoxyribose oxidation assay for Fenton reaction products. Free Radic. Biol. Med. 11:353-360; 1991.
17. Hurley, P. R.; Cook, A.; Jehanli, A.; Austen, B. M.; HermonTaylor, J. Development of radioimmunoassays for free tetra-L-aspartyl-lysine trypsinogen activation peptides (TAP). J. Immunol Methods 111:195-203; 1988.
18. Littauer, A.; DeGroot, H. Release of oxygen species by hepatocytes on reoxygenation: three phases and role of mitochondria. Am. J. Physiol. 267:G1015-G1020; 1992.
19. Wymann, M. P.; von Tscharner, V.; Deranleau, D.; Bagiolini, M. The onset of respiratory burst in human neutrophils. J. Biol. Chem. 262:12048-12053; 1987.
20. Adler, G.; Hahn, C.; Kern, H. F.; Rao, K. N. Caerulein-induced pancreatitis in rats: Increased lysosomal enzyme activity and autophagocytosis. Digestion 32:10-18; 1985.
21. Niederau, C.; Grendell, J. H. Intracellular vacuoles in experimental acute pancreatitis are an acidified compartment. J. Clin. Invest. 88:229-235; 1988.
22. Byrkit, D. R. Analysis of variance. In: Byrkit, D. R., ed. Elements of statistics. New York: Van Nostrand; 1980:305-358.
23. Duncan, D. B. Multiple rank tests for correlated and heteroscedastic means. Biometrics 13:164-176; 1957.
24. Holm, S. A simple sequentially rejective multiple test procedure. Scand. J. Stat. 6:65-70; 1979.
25. Saluja, A. K.; Hashimoto, S.; Saluja, M.; Powers, R. E.; Meldolesi, J.; Steer, M. L. Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis. Am. J. Physiol. 253:G508-G516; 1987.
26. Steer, M. L.; Saluja, A. K. Etiology and pathogenesis of acute pancreatitis. In: Beger, H. G.; Büchler, M.; Malfertheiner, P., eds. Standards in pancreatic surgery. Berlin: Springer Verlag; 1993:13-24.
27. Niederau, C. Experimentelle Pankreatitis. Internist 27:681-696; 1986.
28. Fernandez-del Castillo, C.; Schmidt, J.; Rattner, D. W.; Lewandrowki, K.; Compton, C. C.; Jehali, A.; Patel, G.; Hermon-Taylor, J.; Warshaw, A. I. Generation and possible significance of trypsinogen activation peptides in experimental acute pancreatirtis in the rat. Pancreas 7:263-270; 1992.
29. Grady, T.; Saluja, A.; Saluja, M.; Kaiser, A.; Steer, M. Temporal relationship between trypsinogen activation and the onset of acute pancreatitis. Pancreas 9:A789; 1994.
30. Lüthen, R.; Owen, R. L.; Sarbia, M.; Grendell, J. H.; Niederau, C. Premature zymogen activation inside pancreatic acinar cells during experimental acute pancreatitis: Morphological evidence by labelling of trypsinogen activating peptide. Pancreas 9:A795; 1994.
31. Lüthen, R.; Niederau, C.; Grendell, J. H. Intrapancreatic activation of digestive enzymes during caerulein pancreatitis in rats: a possible role for changes in ATP and glutathione levels. Am. J. Physiol. 268:6592-6604; 1995.
32. Parks, D. A.; Williams, T. K.; Beckman, J. S. Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: a reevaluation. Am. J. Physiol. 254:G768-G774; 1988.
33. McCord, J. M. Oxygen-derived free radicals in postischemic tissue injury. N. Engl. J. Med. 312:159-163; 1985.
34. DeGroot, H.; Littauer, A. Hypoxia, reactive oxygen, and cell injury. Free Radic. Biol. Med. 6:541-551; 1989.
35. Yokoyama, Y.; Parks, D. A. Circulating xanthine oxidase: Release of xanthine oxidase from isolated rat liver. Gastroenterology 94:A607; 1989.