Hepatic amino acid transport

Seminars in Liver Disease

Volumn 16, Issue 2, 1996, Pages 137-145

  Moseley, Richard H ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

alanine; arginine; glutamine

Indexed keywords

AMINO ACID; CARRIER PROTEIN;

AMINO ACID TRANSPORT; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; INTRACELLULAR TRANSPORT; LIVER CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; REVIEW; TISSUE DISTRIBUTION; TRANSPORT KINETICS;

EID: 0029888937     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007227     Document Type: Review

References (121)

1. Sips HJ, Groen AK, Tager JM: Plasma-membrane transport of alanine is rate-limiting for its metabolism in rat-liver parenchymal cells. FEBS Lett 119:271-4, 1980.
2. Katz J, Golden S, Wals PA: Stimulation of hepatic glycogen synthesis by amino acids. Proc Natl Acad Sci USA 73:3433-7, 1976.
3. Rinehart CA Jr, Canellakis ES: Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids. Proc Natl Acad Sci USA 82:4365-8, 1985.
4. Moseley RH: Hepatic uptake of amino acids. In: Tavoloni N, Berk PD (eds): Hepatic transport and bile secretion: Physiology and pathophysiology. New York, Raven Press, 1993, pp. 337-49.
5. Kilberg MS, Haussinger D (eds): Mammalian amino acid transport: Mechanisms and control. New York, Plenum Press, 1992.
6. Kilberg MS, Stevens BR, Novak DA: Recent advances in mammalian amino acid transport. Annu Rev Nutr 13:137-65, 1993.
7. McGivan JD, Pastor-Anglada M: Regulatory and molecular aspects of mammalian amino acid transport. Biochem J 299:321-34, 1994.
8. Mailliard ME, Stevens BR, Mann GE: Amino acid transport by small intestinal, hepatic, and pancreatic epithelia. Gastroenterology 108.888-910, 1995.
9. Mailliard ME, Kilberg MS: Sodium-dependent neutral amino acid transport by human liver plasma membrane vesicles. J Biol Chem 265:14321-6, 1990.
10. Pacitti AJ, Inoue Y, Souba WW: Tumor necrosis factor stimulates amino acid transport in plasma membrane vesicles from rat liver. J Clin Invest 91:474-83, 1993.
11. Gomez-Angelats M, Ruiz-Montasell B, Felipe A, et al: Effect of protein malnutrition on neutral amino acid transport by rat hepatocytes during development. Am J Physiol 268:E368-74, 1995.
12. Shay NF, Nick HS, Kilberg MS: Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells. J Biol Chem 265:17844-8, 1990.
13. Felig P, Marliss E, Ohman JL, Cahill GF: Plasma amino acid levels in diabetic ketoacidosis. Diabetes 19:727-34, 1970.
14. Wahren J, Felig P, Cerasi E, Luft R: Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J Clin Invest 51:1870-5, 1972.
15. Barber EF, Handlogten ME, Vida TA, Kilberg MS: Neutral amino acid transport in hepatocytes isolated from streptozotocin-induced diabetic rats. J Biol Chem 257:14960-7, 1982.
16. Rosenthal NR, Jacob R, Barrett E. Diabetes enhances activity of alanine transport in liver plasma membrane vesicles. Am J Physiol 248:E581-7, 1985.
17. Pastor-Anglada M, Remesar X, Bourdel G: Alanine uptake by liver at nudpregnancy in rats. Am J Physiol 252:E408-13, 1987.
18. Fricker G, Landmann L, Meier PJ: Ethinylestradiol induced structural and functional alterations of rat liver plasma membranes and their reversal by S-adenosylmethionine (Abstract). Hepatology 8:1224, 1988.
19. Le Cam A, Rey J-F, Fehlmann M, et al: Amino acid transport in isolated hepatocytes after partial hepatectomy in the rat. Am J Physiol 236:E594-602, 1979.
20. Dolais-Kitabgi J, Rey JF, Fehlmann M, et al: Effect of insulin and glucagon on amino acid transport in isolated hepatocytes after partial hepatectomy in the rat. Endocrinology 109:868-75, 1981.
21. Fowler FC, Banks RK, Mailliard ME: Characterization of sodium-dependent amino acid transport activity during liver regeneration. Hepatology 16:1187-94, 1992.
22. Haussinger D, Lang F, Kilberg MS: Amino acid transport, cell volume and regulation of cell growth. In: Kilberg MS, Haussinger D (eds): Mammalian amino acid transport: Mechanisms and control. New York, Plenum Press, 1992 pp 113-20.
23. +/L-alanine co-transport in Xenopus laevis oocytes. Biochem J 270:189-95, 1990.
24. Tarnuzzer RW, Campa MJ, Qian N-X, et al: Expression of the mammalian system A neutral amino acid transporter in Xenopus oocytes. J Biol Chem 265:13914-7, 1990.
25. +/glucose cotransporters. J Biol Chem 268:1509-12, 1993.
26. +/glucose cotransporter and not an amino acid transporter. J Biol Chem 269: 22488-91, 1994.
27. Jones M, Gupta RS, Englesberg E: Enhancement in amount of P1 (hsp60) in mutants of Chinese hamster ovary (CHO-K1) cells exhibiting increases in the A system of amino acid transport. Proc Natl Acad Sci USA 91: 858-62, 1994.
28. Piccirillo VJ, Chambers JW: Inhibition of hepatic uptake of alpha aminoisobutyric acid by ethanol: Effects of pyrazole and metabolites of ethanol. Res Comm Chem Path Pharm 13:297-308, 1976.
29. Rosa J, Rubin E: Effects of ethanol on amino acid uptake by rat liver cells. Lab Invest 43:366-72, 1980.
30. Dorio RJ, Hoek JB, Rubin E: Ethanol treatment selectively decreases neutral amino acid transport in cultured hepatocytes. J Biol Chem 259:11430-5, 1984.
31. Moseley RH, Murphy SM: Effects of ethanol on amino acid transport in basolateral liver plasma membrane vesicles. Am J Physiol 256:G458-65, 1989.
32. Smith DJ, Ploch SA: Impaired alanine uptake by basolateral liver plasma membrane vesicles from rats consuming ethanol. Am J Physiol 261:G913-20, 1991.
33. Smith DJ, Daley GDS, Ploch SA: Ethanol consumption decreases alanine uptake by rat basolateral liver plasma membrane vesicles. Gastroenterology 98:429-36, 1990.
34. Mailliard ME, Cariappa R, Banks RK: Impairment of glucagon-induced hepatic system A activity by short-term ethanol administration in the rat. Gastroenterology 106:480-7, 1994.
35. Kilberg MS, Handlogten ME, Christensen HN: Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte. J Biol Chem 256:3304-12, 1981.
36. Kilberg MS, Christensen HN, Hadlogten ME. Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes. Biochem Biophys Res Comm 88:744-51, 1979.
37. Meier PJ, St. Meier-Abt A, Barrett C, Boyer JL: Mechanisms of taurocholate transport in canalicular and basolateral rat liver plasma membrane vesicles. J Biol Chem 259:10614-22, 1984.
38. Simmons TW, Anders MW, Ballatori N: L-Cysteine and S-(1,2-dichlorovinyl)-L-cysteine transport in rat liver canalicular membrane vesicles: Potential reabsorption mechanisms for biliary metabolites of glutathione and its S-conjugates. J Pharm Exp Ther 262: 1182-8, 1992.
39. Cariappa R, Kilberg MS: Plasma membrane domain localization and transcytosis of the glucagon-induced hepatic system A carrier. Am J Physiol 263:E1021-8, 1992.
40. Saiki H, Chan ET, Yamamuro W, et al: Zonal distribution of cysteine uptake in the perfused rat liver. J Biol Chem 267:192-6, 1992.
41. Arriza JL, Kavanaugh MP, Fairman WA, et al: Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J Biol Chem 268:15329-32, 1993.
42. +/glutamate cotransporters. J Biol Chem 268:15351-5, 1993.
43. Huxtable RJ: Physiological actions of taurine. Physiol Rev 72:101-63, 1992.
44. Hardison WGM, Weiner R: Taurine transport by rat hepatocytes in primary culture. Biochim Biophys Acta 598:145-52, 1980.
45. -dependent carrier on the basolateral plasma membrane. Am J Physiol 253:G351-8, 1987.
46. Berkowitz D, Hug P, Sleight RG, Bucuvalas JC: Fasting enhances taurine transport by rat liver plasma membrane vesicles. Am J Physiol 267:G932-7, 1994.
47. --dependent taurine transporter that is regulated by hypertonicity. Proc Natl Acad Sci USA 89:8230-4, 1992.
48. Smith KE, Borden LA, Wang C-HD. et al: Cloning and expression of a high affinity taurine transporter from rat brain. Mol Pharm 42:563-9, 1992.
49. Liu Q-R, López-Corcuera B, Nelson H, et al: Cloning and expression of a cDNA encoding the transporter of taurine and β-alanine in mouse brain. Proc Natl Acad Sci USA 89:12145-9, 1992.
50. Jhiang SM, Fithian L, Smanik P, et al: Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells. FEBS Lett 318:139-44, 1993.
51. Ramamoorthy S, Leibach FH, Mahesh VB, et al: Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem J 300:893-900, 1994.
52. Uhl GR, Hartig PR: Transporter explosion: Update on uptake. TIPS 13:421-5, 1992.
53. --dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene. J Clin Invest 91:1604-7, 1993.
54. Takenaka M, Bagnasco SM, Preston AS, et al: The canine betaine γ-amino-n-butyric acid transporter gene: Diverse mRNA isoforms are regulated by hypertonicity and are expressed in a tissue-specific manner. Proc Natl Acad Sci USA 92:1072-6, 1995.
55. Takenaka M, Preston AS, Kwon HM, Handler JS: The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress. J Biol Chem 269:29379-81, 1994.
56. Häussinger D, Lang F, Gerok W: Regulation of cell function by the cellular hydration state. Am J Physiol 267:E343-55, 1994.
57. Brand HS, Meijer AJ, Gustafson LA, et al: Cell-swelling-induced taurine release from isolated perfused rat liver. Biochem Cell Biol 72:8-11, 1993.
58. Gazzola GC, Dall'Asta V, Bussolati O, et al: A stereoselective anomaly in dicarboxylic amino acid transport. J Biol Chem 256:6054-9, 1981.
59. Makowske M, Christensen HN: Contrasts in transport sytems for anionic amino acids in hepatocytes and a hepatoma cell line HTC. J Biol Chem 257:5663-70, 1982.
60. Takada A, Bannai S: Transport of cystine in isolated rat hepatocytes in primary culture. J Biol Chem 259:2441-5, 1984.
61. Ballatori N, Moseley RH, Boyer JL: Sodium gradient-dependent L-glutamate transport is localized to the canalicular domain of liver plasma membranes. J Biol Chem 261:6216-21, 1986.
62. Low SY, Hundal HS, Taylor PMM, et al: Glutamate uptake in sinusoidal membrane vesicles isolated from rat liver: Effects of streptozocin diabetes. Biochem Soc Trans 18:1244-5, 1990.
63. Low SY, Taylor PM, Hundal HS, et al: Transport of L-glutamine and L-glutamate across sinusoidal membranes of rat liver. Biochem J 284:333-40, 1992.
64. Taylor PM, Rennie MJ: Perivenous localisation of Na-dependent glutamate transport in perfused rat liver. FEBS Lett 221:370-4, 1987.
65. 4. J Hepatol 4:381-98, 1987.
66. 13N-labeled glutamate, alanine, and glutamine (amide) in rat liver. J Biol Chem 263:12268-73, 1988.
67. Stoll B, McNelly S, Buscher H-P, Haussinger D: Functional hepatocyte heterogeneity in glutamate, aspartate and α-ketoglutarate uptake: A histoautoradiographical study. Hepatology 13:247-53, 1991.
68. Burger H-J, Gebhardt R, Mayer C, Mecke D: Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion. Hepatology 9:22-8, 1989.
69. Takeda H, Sipple SJ, Moseley RH: Glutamate transport by rat liver plasma membrane vesicles (Abstract). Gastroenterology 104:A1003, 1993.
70. +-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci USA 89:10955-9, 1992.
71. Pines G, Danbolt NC, Bjørås M, et al: Cloning and expression of a rat brain L-glutamate transporter. Nature 360:464-7, 1992.
72. Kanai Y, Hediger MA: Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360:467-71, 1992.
73. Kanai Y, Smith CP, Hediger MA: A new family of neurotransmitter transporters: The high-affinity glutamate transporters. FASEB J 8:1450-9, 1994.
74. Gebhardt R, Kleemann E: Hormonal regulation of amino acid transport system N in primary cultures of rat hepatocytes. Eur J Biochem 16:339-44, 1987.
75. Kilberg MS, Handlogten ME, Christensen HN: Characteristics of an amino acid transport system in rat liver for glutamine. asparagine, histidine, and closely related analogs. J Biol Chem 255:4011-9, 1980.
76. Rémésy C, Morand C, Demigné C, et al: Control of hepatic utilization of glutamine by transport processes or cellular metabolism in rats fed a high protein diet. J Nutr 118:569-78, 1988.
77. Bode BP, Kilberg MS: Amino acid-dependent increase in hepatic system N activity is linked to cell swelling. J Biol Chem 266:7376-81, 1991.
78. Taylor PM, Mackenzie B, Low SY, Rennie MJ: Expression of rat liver glutamine transporters in Xenopus laevis oocytes. J Biol Chem 267:3873-7, 1992.
79. Tamarappoo BK, Kilberg MS: Functional reconstitution of the hepatic system N amino acid transport activity. Biochem J 274:97-101, 1991.
80. Tamarappoo BK, Handlogten ME, Laine RO, et al: Identification of the protein responsible for hepatic system N amino acid transport activity. J Biol Chem 267:2370-4, 1992.
81. Fafournoux P, Demigné C, Rémésy C, Le Cam A: Bidirectional transport of glutamine across the cell membrane in rat liver. Biochem J 216:401-8, 1983.
82. +-independent system for glutamine transport in rat liver basolateral membrane vesicles. Gastroenterology 101:1094-101, 1991.
83. +-independent glutamine transport in rat liver. Am J Physiol 265:G90-8, 1993.
84. Häussinger D: Nitrogen metabolism in liver: Structural and functional organization and physiological relevance. Biochem J 267:281-90, 1990.
85. Häussinger D, Soboll S, Meijer AJ, et al: Role of plasma membrane transport in hepatic glutamine metabolism. Eur J Biochem 152:597-603, 1985.
86. Burger H-J, Gebhardt R, Mayer C, Mecke D: Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion. Hepatology 9:22-8, 1989.
87. Kaiser S, Gerok W, Häussinger D: Ammonia and glutamine metabolism in human liver slices: New aspects on the pathogenesis of hyperammonaemia in chronic liver disease. Eur J Clin Invest 18:535-42, 1988.
88. Boon L, Blommaart PJE, Meijer AJ, et al: Acute acidosis inhibits liver amino acid transport: No primary role for the urea cycle in acid-base balance. Am J Physiol 267:F1015-20, 1994.
89. White MF: The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim Biophys Acta 822.355-74, 1985.
90. Wang H, Kavanaugh MP, North RA, Kabat D: Cell-surface receptor for ecotropic murine retroviruses is a basic amino-acid transporter. Nature 352:729-31, 1991.
91. Kim JW, Closs EI, Albritton LM, Cunningham JM: Transport of canonic amino acids by the mouse ecotropic retrovirus receptor. Nature 352:725-8, 1991.
92. Closs EI, Albritton JM, Kim JW, Cunningham JM: Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. J Biol Chem 268:7538-44, 1993.
93. Kavanaugh MP, Wang H, Zhang Z, et al: Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. J Biol Chem 269:15445-50, 1994.
94. Closs EI, Lyons CR, Kelly C, Cunningham JM: Characterization of the third member of the MCAT family of cationic amino acid transporters. J Biol Chem 268:20796-800, 1993.
95. Inoue Y, Bode BP, Beck DJ, et al: Arginine transport in human liver: Characterization and effects of nitric oxide synthase inhibitors. Ann Surg 218:350-63, 1993.
96. Wettstein M, Gerok W, Haussinger D: Endotoxin-induced nitric oxide synthesis in the perfused rat liver: Effects of L-arginine and ammonium chloride. Hepatology 19:641-7, 1994.
97. -mediated L-arginme transport by an inflammatory agent. Surgery 112:403-11, 1992.
98. Lumsden AB, Henderson JM, Kutner MH: Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis. Hepatology 8:232-6, 1988.
99. Vallance P, Moncsda S: Hyperdynamic circulation in cirrhosis: A role for nitric oxide? Lancet 337:776-8, 1991.
100. Matsumoto A, Ogura K, Hirata Y, et al: Increased nitric oxide in the exhaled air of patients with decompensated liver cirrhosis. Ann Intern Med 123:110-3, 1995.
101. Christensen HN, Handlogten ME: Role of system Gly in glycine transport in monolayer cultures of liver cells. Biochem Biophys Res Commun 98:102-7, 1981.
102. --glycine cotransport in canalicular liver plasma membrane vesicles. Am J Physiol 255:G253-9, 1988.
103. Bossard R, Stieger B, O'Neill B, et al: Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. J Clin Invest 91:2714-20, 1993.
104. Smith KE, Borden LA, Hartig PR, et al: Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors. Neuron 8:927-35, 1992.
105. Guastella J, Brecha N, Weigmann C, et al: Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc Natl Acad Sci USA 89:7189-93, 1992.
106. Liu Q-R, López-Corcuera B, Mandiyan S, et al: Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features. J Biol Chem 268:22802-8, 1993.
107. Kim K-M, Kingsmore SF, Han H, et al: Cloning of the human glycine transporter type 1: Molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. Mol Pharm 45:608-17, 1994.
108. Borowsky B, Mezey E, Hoffman BJ: Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene. Neuron 10:851-63, 1993.
109. Núñez E, Aragón C: Structural analysis and functional role of the carbohydrate component of glycine transporter. J Biol Chem 269:16920-4, 1994.
110. Olivares L, Aragón C, Giménez C, Zafra F: The role of N-glycosylation in the targeting and activity of the GLYT1 glycine transporter. J Biol Chem 270: 9437-42, 1995.
111. Shotwell MA, Kilberg MS, Oxender DL: The regulation of neutral ammo acid transport in mammalian cells. Biochim Biophys Acta 737:267-84, 1983.
112. +-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. J Biol Chem 257:12006-11, 1982.
113. Novak DA, Kilberg MS, Beveridge MJ: Ontogeny and plasma-membrane domain localization of amino acid transport system L in rat liver. Biochem J 301:671-4, 1994.
114. Salter M, Knowles RG, Pogson CI: Transport of the aromatic amino acids into isolated rat liver cells. Biochem J 233:499-506, 1986.
115. Wells RG, Hediger MA: Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases. Proc Natl Acad Sci USA 89:5596-600, 1992.
116. --independent neutral amino acid transporter from rat kidney. Proc Natl Acad Sci USA 89:1-5, 1992.
117. Pickel VM, Nirenberg MJ, Chan J, et al: Ultrastructural localization of a neutral and basic amino acid transporter in rat kidney and intestine. Proc Natl Acad Sci USA 90:7779-83, 1993.
118. Bertran J, Werner A, Moore ML, et al: Expression cloning of a cDNA from rabbit kidney cortex that induces a single transport system for cystine and dibasic and neutral amino acids. Proc Natl Acad Sci USA 89:5601-5, 1992.
119. Bertran J, Werner A, Chillarón J, et al: Expression cloning of a human renal cDNA that induces high affinity transport of L-cystine shared with dibasic amino acids in Xenopus oocytes. J Biol Chem 268:14841-9, 1993.
120. --like amino acid transport by the heavy chain of human 4F2 surface antigen in Xenopus laevis oocytes. Proc Natl Acad Sci USA 89:5606-10, 1992.
121. Wells RG, Lee W-S, Kanai Y, et al: The 4F2 antigen heavy chain induces uptake of neutral and dibasic amino acids in Xenopus oocytes. J Biol Chem 267:15285-8, 1992.