A novel guinea pig heart model for studying AV nodal conduction and triggered activity in vivo

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 5 39-5, 1996, Pages

  Xu, Jiang ^a   Pelleg, Amir ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

after depolarizations; cesium chloride; digoxin; monophasic action potential; ventricular arrhythmias

Indexed keywords

CESIUM CHLORIDE; DIGOXIN;

ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; GUINEA PIG; HEART ATRIOVENTRICULAR NODE; HEART DEPOLARIZATION; HEART MUSCLE POTENTIAL; HEART VENTRICLE ARRHYTHMIA; HIS BUNDLE; MUSCLE ACTION POTENTIAL; NONHUMAN; PRIORITY JOURNAL;

EID: 0029888824     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.5.h1850     Document Type: Article

References (21)

1. 1-adenosine receptor enhancer of the negative dromotropic action of adenosine in the guinea pig heart. J. Pharmacol. Exp. Ther. 266: 611-617, 1993.
2. Antzelevitch, C., and S. Sicouri. Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and Torsades de Pointes. J. Am. Cell. Cardiol. 23: 259-277, 1994.
3. Cambridge, D., C. R. Morgan, and G. Allen. Digoxin and digoxin derivative-induced arrhythmias: in vitro binding and in vivo abolition of arrhythmias by digoxin-immune Fab (digibind). Cardiovasc. Res. 26: 906-911, 1992.
4. Chen, S.-A., C.-E. Chiang, C.-J. Yang, C.-C. Cheng, T.-J. Wu, S.-P. Wang, B. N. Chiang, and M.-S. Chang. Sustained atrial tachycardia in adult patients. Electrophysiological characteristics, pharmacological response, possible mechanisms, and effects of radiofrequency ablation. Circulation 90: 1262-1278, 1994.
5. Cranefield, P. F., and R. S. Aronson. Cardiac Arrhythmias: The Role of Triggered Activity and Other Mechanisms. Mount Kisco, NY: Futura, 1988.
6. Ferrier, G. R. Digitalis arrhythmias: role of oscillatory afterdepolarizations. Prog. Cardiovasc. Dis. 19: p. 459-474, 1977.
7. Franz, M. R. Longterm recording of monophasic action potentials from human endocardium. Am. J. Cardiol. 51: 1629-1634, 1983.
8. Gorgels, A. P. M., M. A. Vos, J. L. R. M. Sweets, E. Kriek, P. Brugada, and A. J. J. Wellens. Delayed afterdepolarizations and atrial and ventricular arrhythmias. In: Cardiac Electrophysiology: A Textbook, edited by M. R. Rosen, M. J. Janse, and A. L. Wit. Mount Kisco, NY: Futura, 1990, p. 341-359.
9. Kanaan, N., J. Jenkins, K. Childs, Y.-Z. Ge, and A. Kadish. Monophasic action potential duration during programmed electrical stimulation. Pacing Clin. Electrophysiol. 14: 1049-1059, 1991.
10. Kollias-Baker, C., J. Xu, A. Pelleg, and L. Belardinelli. A novel approach to enhance the cardiac actions of endogenous adenosine. Circ. Res. 75: 972-980, 1994.
11. Lathrop, D. A., P. P. Nanasi, and A. Varro. In vitro cardiac model of dog Purkinje fibre triggered and spontaneous electrical activity: effects of nicorandil. Br. J. Pharmacol. 99: 119-123, 1990.
12. Levine, J. H., E. N. Moore, A. H. Kadish, T. Guarnieri, and J. F. Spear. The monophasic action potential upstroke: a means of characterizing local conduction. Circulation 74: 1147-1155, 1986.
13. Levine, J. H., J. F. Spear, T. Guarnieri, M. L. Weisfeldt, C. D. J. DeLangen, L. C. Becker, and E. N. Moore. Cesium chloride-induced long QT syndrome: demonstration of afterdepolarizations and triggered activity in vivo. Circulation 72: 1092-1103, 1985.
14. Moore, K. B., T. Kimball, and B. Steadman. Silver-silver chloride plunge electrode needles and chloriding monitor. IEEE Trans. Biomed. Eng. 37: 532-535, 1990.
15. Olsson, S. B., P. Blomström, C. Blomström-Lundqvist, and B. Wohlfart. Endocardial monophasic action potential. Ann. NY Acad. Sci. 601: 119-127, 1990.
16. Priori, S. G., M. Mantica, and P. J. Sehwartz. Delayed afterdepolarization elicited in vivo by left stellate ganglion stimulation. Circulation 78: 178-185, 1988.
17. Rosen, M. R., and S. Danilo. Digitalis induced delayed afterdepolarizations. In: Slow Inward Current and Cardiac Arrhythmias, edited by D. Zipes, J. Bailey, and V. Ellazari. The Hague: Martinus Nijhoff, 1980, p. 417-435.
18. Rosen, M. R., and R. F. Roden. Does triggered activity have a role in the genesis of cardiac arrhythmias? Ann. Intern. Med. 94: 794-801, 1981.
19. Xu, J., C. M. Hurt, and A. Pelleg. Digoxin-induced ventricular arrhythmias in the guinea-pig heart in vivo: evidence for a role of endogenous catecholamines in the genesis of delayed afterdepolarizations and triggered activity. Heart Vessels 10: 119-127, 1995.
20. 1-adenosine receptor and pertussis toxin sensitive guanine micleotide binding-protein mediate hypoxia-indueed atrioventricular nodal conduction block in the guinea-pig heart in vivo. Cardiovasc. Res. 27: 139-140, 1993.
21. - channels in the hypoxic guinea-pig ventricle in vivo. Circulation 89: 1209-1216, 1994.