Bacteriophage T4 mutants hypersensitive to an antitumor agent that induces topoisomerase-DNA cleavage complexes

Genetics

Volumn 143, Issue 3, 1996, Pages 1081-1090

  Woodworth, Denise L ^a,b   Kreuzer, Kenneth N ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MUHLENBERG COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTINEOPLASTIC AGENT; BACTERIOPHAGE DNA; DNA TOPOISOMERASE; EXONUCLEASE;

ARTICLE; BACTERIOPHAGE T4; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; GENE DELETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; ULTRAVIOLET RADIATION;

AMINO ACID SEQUENCE; AMSACRINE; ANTINEOPLASTIC AGENTS; BACTERIOPHAGE T4; BASE SEQUENCE; DNA TOPOISOMERASES, TYPE II; DNA TRANSPOSABLE ELEMENTS; DNA, VIRAL; DNA-BINDING PROTEINS; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; RIBONUCLEASE H, CALF THYMUS; ULTRAVIOLET RAYS; VIRAL PROTEINS;

EID: 0029888199     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. BERNSTEIN, C., 1981 Deoxyribonucleic acid repair in bacteriophage. Microbiol. Rev. 45: 72-98.
2. CARLSON, K., E. A. RALEIGH and S. HATTMAN, 1994 Restriction and modification, pp. 369-381 in Molecular Biology of Bacteriophage T4, edited byj. D. KARAM. American Society for Microbiology, Washington, DC.
3. CHEN, A. Y., and L. F. Liu, 1994 DNA topoisomerases: essential enzymes and lethal targets. Annu. Rev. Pharmacol. Toxicol. 34: 191-218.
4. CONKLJN'G, M. A., and J. W. DRAKE, 1984 Isolation and characterization of conditional alleles of bacteriophage T4 genes itvsX and uvsY. Genetics 107: 505-523.
5. DERR, L. K., and K. N. KREUZER, 1990 Expression and function of the uvsW gene of bacteriophage T4. J. Mol. Biol. 214: 643-656.
6. DRAKE, J. W., 1994 UV irradiation of T4 (Appendix), p. 451 in Molecular Biology of Bacteriophage T4, edited byj. D. KARAM. American Society for Microbiology, Washington, DC.
7. EDGAR, R. S., G. H. DENIIARDT and R. H. EPSTEINJ, 1964 A comparative study of conditional lethal mutants of bacteriophage T4D. Genetics 49: 635-648.
8. ENG, W.-K., L. FAUCETTE, R. K. JOHNSON and R. STERNGLANZ, 1989 Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol. Pharmacol. 34: 755-760.
9. ENGMAN, H. W., and K. N. KRïUZER, 1993 Deletion of the essential gene 24 from the bacteriophage T4 genome. Gene 123: 69-74.
10. GLISSON, B. S., and W. E. Ross, 1987 DNA topoisomerase II: a primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy. Pharmac. Ther. 32: 89-106.
11. HAMLETT, N. V., and H. BERGER, 1975 Mutations altering genetic recombination and repair of DNA in bacteriophage T4. Virology 63: 539-567.
12. HANE, M. W., and T. H. WOOD, 1969 Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominance stud ies.J. Bacteriol. 99: 238-241.
13. HARRIS, L. D., and J. D. GRIFFITH, 1989 UvsY protein of bacteriophage T4 is an accessory protein for in vitro catalysis of strand exchange. J. Mol. Biol. 206: 19-27.
14. HOLUNGSWORTH, H. C, and N. G. NOSSAL, 1991 Bacteriophage T4 encodes an RNase H which removes RNA primers made by the T4 DNA replication system in vitro. J. Biol. Chem. 266: 1888-1897.
15. HsiEH, T., 1990 Mechanistic aspects of type-II DNA topoisomerases, pp. 243-263 in DNA Topology and Its Biological Effects, edited by N. R. COZZARELLI and J. C. WANG. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
16. HUFF, A. C., and K. N. KREUZER, 1990 Evidence for a common mechanism of action for antitumor and antibacterial agents that inhibit type II DNA topoisomerase. J. Biol. Chem. 265: 2049620505.
17. HUFF, A. C., J. K. LEATIIER\VOOD and K. N. KREUZER, 1989 Bacteriophage T4 topoisomerase is the target of antitumor agent 4'(9-acridinyIamino)methanesulfon-n-anisidide (m-AMSA) in T4infected Escherichia coli. Proc. Nad. Acad. Sei. USA 86: 13071311.
18. HUFF, A. C., R. E. WARD IV and K. N. KREUZER, 1990 Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent mAMSA. Mol. Gen. Genet. 221: 27-32.
19. JEGGO, P.A., K. CALDECOTT, S. PiDSLEYand G. R. BANKS, 1989 Sensitivity of Chinese hamster ovary mutants defective in DNA double strand break repair to topoisomerase II inhibitors. Cancer Res. 49: 7057-7063.
20. KARAM, J. D., 1994 Molecular Biology of Bacteriophage T4. American Society for Microbiology, Washington, DC.
21. KODADEK, T., D.-C. GAN and K. STEMKE-HALE, 1989 The phage T4 uvsY recombination protein stabilizes presynaptic filaments. J. Biol. Chem. 264: 16451-16457.
22. KOGOMA, T., X. HONG, G. W. CADNT.LL, K. G. BARNARD and T. ASAI, 1993 Requirement of homologous recombination functions for viability of the Escherichia coli cell that lacks RNase HI and exonuclease V activities. Biochimie 75: 89-99.
23. KöNIGSBERG, W., and G. N. GODSON, 1983 Evidence for use of rare codons in the dnaG gene and other regulatory genes of Escherichia coli. Proc. Nail. Acad. Sei. USA 80: 687-691.
24. KREUZER, K. N., and B. M. ALBERTS, 1984 Site-specific recognition of bacteriophage T4 DNA by T4 type II DNA topoisomerase and Escherichia coli DNA gyrase. J. Biol. Chem. 259: 5339-5346.
25. KREUZER, K. N., andj. W. DRAKE, 1994 Repair of lethal DNA damage, pp. 89-97 in Molecular Biology of Bacteriophage T4, edited byj. D. KARAM. American Society for Microbiology, Washington, DC.
26. KREUZER, K. N., and C. V. JONGENEEL, 1983 Escherichia coli phage T4 topoisomerase. Methods Enzymol. 100: 144-160.
27. KREUZER, K. N., and S. W. MORRICAL, 1994 Initiation of DNA replication, pp. 28-42 in Molecular Biology of Bacteriophage T4, edited by J. D. KARAM. American Society for Microbiology, Washington, DC.
28. KREUZER, K. N., and H. E. SEUCK, 1994 Directed insertion/substitution mutagenesis, pp. 452-454 in Molecular Biology of Bacteriophage T4, edited byj. D. KARAM. American Society for Microbiology, Washington, DC.
29. KREUZER, K. N., H. W. ENGMAN and W. Y. YAP, 1988 Tertiary initiation of replication in bacteriophage T4. J. Biol. Chem. 263: 11348-11357.
30. KUTTER, E., T. STIDIIAM, B. GUTTMAN, D. BATTS, S. PETERSON et al., 1994 Genomic map of bacteriophage T4, pp. 491-519 in Molecular Biology of Bacteriophage T4, edited byj. D. KARAM. American Society for Microbiology, Washington, DC.
31. Liu, L. F., 1989 DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 58: 351-375.
32. Liu, L. F., C.-C. Liu and B. M. ALBERTS, 1979 T4 DNA topoisomerase: a new ATP-dependent enzyme essential for initiation of T4 bacteriophage DNA replication. Nature 281: 456-461.
33. MATSON, S. W., 1989 Escherichia coli DNA helicase II (uvrD gene product) catalyzes the unwinding of DNA-RNA hybrids in vitro. Proc. Nad. Acad. Sei. USA 86: 4430-4434.
34. McDANiEL, L. S., L. H. ROGERS and W: E. HILL, 1978 Survival of recombination-deficient mutants of Escherichia coli during incubation with nalidixic acid. J. Bacteriol. 134: 1195-1198.
35. MICKELSON, G., andj. S. WlBERG,'i981 Membrane-associated DNase activity controlled by genes 46 and 47 of bacteriophage T4D and derated DNase activity associated with the T4 das mutation. J. Virol. 40: 65-77.
36. NEECE, S. H., K. CARLES-KINCH, D. J. TOMSO and K. N. KREUZER, 1996 Role of recombinational repair in sensitivity to an antitumor agent that inhibits bacteriophage T4 type II DNA topoisomerase. Mol. Microbiol. (In press).
37. NELSON, E. M., K. M. TEWEY and L. F. Liu, 1984 Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesuIfon-m-anisidide. Proc. Natl. Acad. Sei. USA 81: 1361-1365.
38. Nmss.J., and J. G. WANG, 1988 DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc. Natl. Acad. Sei. USA 85: 7501-7505.
39. Nmss.J. L., Y. X. Liu, P. HARBURY, M. JANNATIPOUR, R. WASSER.MAN et al, 1992 Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II. Cancer Res. 52: 4467-4472.
40. REECE, R. J., and A. MAXWELL, 1991 DNA gyrase: structure and function. CRC Crit. Rev. Biochem. Mol. Biol. 26: 335-375.
41. SELICK, H. E., K. N. KREUZER and B. M. ALBERTS, 1988 The bacteriophage T4 insertion/substitution vector system. J. Biol. Chem. 263: 11336-11347.
42. SEUCK, H. E., G. D. STORMO, R. L. D\SON and B. M. ALBERTS, 1993 Analysis of five presumptive protein-coding sequences clustered between the primosome genes, 41 and 61, of bacteriophages T4, T2, and T6. J. Virol. 67: 2305-2316.
43. SNUSTAD, D. P., L. SNYDER and E. M. KUTTER, 1983 Effects on host genome structure and expression, pp. 40-57 in Bacteriophage T-t, edited by C. K. MATHEWS, E. M. KUTTER, G. MosiG and P. B. BERGET. American Society for Microbiology, Washington, DC.
44. STETLER, G. L., G. J. KING and W. M. HUANG, 1979 T4 DNA-delay proteins, required for specific DNA replication, form a complex that has ATP-dependent DNA topoisomerase activity. Proc. Natl. Acad. Sei. USA 76: 3737-3741.
45. STUDIER, F. W., A. H. ROSENBERG, J. J. DüNN and J. W. DUBENDORFF, 1990 Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol. 185: 60-89.
46. SYMONDS, N., H. HEINDL and P. WHITE, 1973 Radiation sensitive mutants of phage T4. A comparative study. Mol. Gen. Genet. 120: 253-259.
47. TAKAIIASHI,H.,M.KOBAYASHI,T.NOGUCHI and H.SAITO, 1985 Nucleotide sequence of bacteriophage T4 uvsY gene. Virology 147: 349-353.
48. TSENG, M.-J., P. HE, J. M. HILFINGER and G. R. GREENBERG, 1990 Bacteriophage T4 nrrfAand nrdBgenes, encoding ribonucleotide reductase, are expressed both separately and coordinately: characterization of the nrdB promoter. J. Bacteriol. 172: 6323-6332.
49. WANG, J. C., 1991 DNA topoisomerases: why so many. J. Biol. Chem. 266: 6659-6662.
50. WANG, J. C., P. R. CARON and R. A. KIM, 1990 The role of DNA topoisomerases in recombination and genome stability: a doubleedged sword. Cell 62: 403-406.
51. WIEGAND, T. W., and W. S. REZNIKOFF, 1992 Characterization of two hypertransposing Tn.5 mutants. J. Bacteriol. 174: 1229-1239.
52. WIRAK, D. O., K. S. COOK and G. R. GREENBERG, 1988 Defect in synthesis of deoxyribonucleotides by a bacteriophage T4 nrdB mutant is suppressed on mutation of T4 DNA topoisomerase gene.J. Biol. Chem. 263: 6193-6201.
53. WOODWORTH, D. L., and K. N. KREUZER, 1992 A system of transposon mutagenesis for bacteriophage T4. Mol. Microbiol. 6: 12891296.
54. YAP, W. Y., and K. N. KREUZER, 1991 Recombination hotspots in bacteriophage T4 are dependent on replication origins. Proc. Natl. Acad. Sei. USA 88: 6043-6047.
55. YEII, Y. C., and I. TESSMAN, 1972 Control of pyrimidine biosynthesis by phage T4. II. In vitro complementation between ribonucleotide reductase mutants. Virology 47: 767-772.
56. YONESAKI, T., and T. MlNAGAWA, 1989 Synergistic action of three recombination gene products of bacteriophage T4, uvsX, uvsY, and gene 32 proteins. J. Biol. Chem. 264: 7814-7820.