Overexpression of the c-myc proto-oncogene in colorectal carcinoma is associated with a reduced mortality that is abrogated by point mutation of the p53 tumor suppressor gene

Clinical Cancer Research

Volumn 2, Issue 6, 1996, Pages 1049-1053

  Smith, Duncan R ^a,b   Goh, Hak Su ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b TAN TOCK SENG HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER MORTALITY; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE C MYC; POINT MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; FEMALE; GENES, MYC; GENES, P53; HUMANS; MALE; MIDDLE AGED; POINT MUTATION; SURVIVAL RATE;

EID: 0029888182     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Venstrom, B., Sheiness, D., Zabielski, J., and Bishop, J. Isolation and characterisation of c-myc, a cellular homologue of the oncogene (v-myc) of avian myelocytomatosis virus, strain 29. J. Virol., 42: 773-779, 1982.
2. DePinho, R. A., Mitsock, L., Hatton, K., Ferrier, P., Zimmerman, K., LeGouy, E., Tesfaye, A., Collum, R., Yancopoulos, G., Nisen, P., Kriz, R , and Alt, F. myc family of cellular oncogenes. J. Cell. Biochem., 33: 257-266, 1987.
3. DePinho, R. A., Schreiber-Agus, N., and Alt, F. W. myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res., 57: 1-46, 1991.
4. Morgenbesser, S. D., and DePinho, R. A. Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer. Semin. Cancer Biol., 5: 21-36, 1994.
5. Canman, C. E., and Kastan, M. B. Induction of apoptosis by tumour suppressor genes and oncogenes. Semin. Cancer Biol., 6: 17-25, 1995.
6. Erisman, M. D., Litwin, S., Ketchan, R. D., Cornis, R. L., and Astrin, S. M. Noncorrelation of the expression of the c-myc oncogene in colorectal carcinoma with recurrence of the disease or patient survival. Cancer Res., 48: 1350-1355, 1988.
7. Tsuboi, K., Hirayoshi, K., Takeuchi, K., Sabe, H., Shimada, Y., Ohshio, G., Tobe, T., and Hatanaka, M. Expression of c-myc gene in human gastrointestinal malignancies. Biochem. Biophys. Res. Commun., 146: 699-704, 1987.
8. Smith, D. R., Myint, T., and Goh, H-S. Over-expression of the c-myc proto- oncogene in colorectal carcinoma. Br. J. Cancer, 68: 407-413, 1993.
9. Meek, D. W. Post-translational modification of p53. Semin. Cancer Biol., 5: 203-210, 1994.
10. Deppert, W. The yin and yang of p53 in cellular proliferation. Semin. Cancer Biol., 5: 187-202, 1994.
11. Zambetti, G. P., Bargonetti, J., Walker, K., Prives, C., and Levine, A. J. Wild type p53 mediates positive regulation of gene expression through a specific DNA element. Genes & Dev., 6: 1143-1152, 1992.
12. Oren, M Relationship of p53 to the control of apoptotic cell death. Semin. Cancer Biol., 5: 221-227, 1994.
13. Blondal, J. A., and Benchimol, S. The role of p53 in tumour progression. Semin. Cancer Biol., 5: 177-186, 1994.
14. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. p53 mutations in human cancers. Science (Washington DC), 253: 49-53, 1991.
15. Baker, S. J., Preisinger, A. C., Jessup, J. K., Paraskeva, C., Markowitz, S., Willson, J. K., Hamilton, S., and Vogelstein, B. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res., 50: 7717-7722, 1990.
16. Goh, H-S., Chan, C-S., Rhine, K., and Smith, D. R. p53 and behaviour of colorectal cancer. Lancet, 344: 233-234, 1994.
17. Goh, H-S., Yao, J., and Smith, D. R. p53 point mutation and survival in colorectal cancer patients. Cancer Res., 55: 5217-5221, 1995.
18. Hamelin, R., Laurent-Puig, P., Olshwang, S., Jego, N., Asselain, B., Remvikos, Y., Girodet, J., Salmon, R. J., and Thomas, G. Association of p53 mutations with short survival in colorectal cancer. Gastroenterology, 106: 42-48, 1994.
19. Orita, M., Iwahana, H., Hayashi, K., and Sekiya, T. Detection of polymorphisms of human DNA by gel electrophoresis as single strand conformational polymorphisms. Proc. Natl. Acad. Sci. USA, 86: 2766-2770, 1989.
20. Sakai, E., and Tsuchida, N. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumour suppressor genes. Oncogene, 7: 927-933, 1992.
21. Smith, D. R., Chan, C-S., and Goh, H-S. A detailed study of p53 mutation in colorectal cancer in Singapore. Ann. Acad Med. Singapore, 23: 803-809, 1994.
22. Smith, D. R., Khine, K., Chan, C-S., and Goh, H-S. Tumour suppressor genes in colorectal carcinomas: p53 inactivation is highly associated with allelic loss of chromosome 5q. Int. J. Oncol., 5: 539-546, 1994.
23. Kaplan, E. L., and Meier, P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc., 53: 475-481, 1958.
24. Bellamy, C. O. C., Malcomson, R. D. G., Harrison, D. J., and Wyllie, A. H. Cell death in health and disease: the biology and regulation of apoptosis. Semin. Cancer Biol., 6: 3-16, 1995.
25. Eastman, A. Survival factors, intracellular signal transduction, and the activation of endonucleases in apoptosis. Semin. Cancer Biol., 6: 45-52, 1995.
26. Wyllie, A. H., Rose, K. A., Morris, R. G., Steel, C. M., Foster, E., and Spandidos, D. A. Rodent fibroblast tumours expressing human myc and ras genes: growth, metastasis and endogenous oncogene expression. Br. J. Cancer, 56: 251-259, 1987.
27. Arrends, M. J., McGregor, A. H., and Wyllie, A. H. Apoptosis is inversely related to necrosis and determines net growth in tumours bearing constitutively expressed myc, ras and HPV oncogenes. Am J. Pathol., 144: 1045-1057, 1994.
28. Lowe, S. W., Bodis, S., McClatchey, A., Remington, L., Ruley, H. E., Fisher, D. E., Houseman, D. E., and Jacks, T p53 status and the efficiency of cancer therapy in vivo. Science (Washington DC), 266: 807-810, 1994.
29. Hermeking, H., and Eick, D. Mediation of c-Myc induced apoptosis by p53 Science (Washington DC), 265: 2091-2093, 1994.