Haloperidol inhibits neuronal nitric oxide synthase activity by preventing electron transfer

Neuropsychobiology

Volumn 33, Issue 2, 1996, Pages 76-79

  Iwahashi, Kazuhiko ^a   Yoneyama, Hirohito ^a   Ohnishi, Taira ^a   Nakamura, Kazuhiko ^a   Miyatake, Ryosuke ^a   Suwaki, Hiroshi ^a   Hosokawa, Kiyoshi ^a   Ichikawa, Yoshiyuki ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Haloperidol; Inhibition; L Arginine; NADPH; NOS; Oxyhemoglobin; P45O

Indexed keywords

ARGININE; CITRULLINE; HALOPERIDOL; NEUROLEPTIC AGENT; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYHEMOGLOBIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SWINE;

ANIMALS; ARGININE; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; NADP; NITRIC OXIDE SYNTHASE; SWINE;

EID: 0029888026     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000119253     Document Type: Article

References (17)

1. Bredt DS, Snyder SH: Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme, Proc Natl Acad Sci USA 1990:87:682-685.
2. Bredt DS, Svnder SH: Nitric oxide, a novel neuronal messenger, Neuron 1992:8:3-11.
3. Forstermann U, Pollock JS, Schmidt HHW II, Heller M, Murad F: Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells, Proc Natl Acad Sci USA 1991,88: 1788-1792.
4. Ikcda M, Matsui K, Ishihara Y, Morita I, Mu-rota S, Yuasa T, Miyake T: Cerebellar nitric oxide synthase, cGMP and motor function in two lines of cerebellar mutant mice, Staggerer and Wriggle Mouse Sagarni, Ncurosci Lett 1994:168:65-68.
5. Izumi Y, Clifford DB, Zoruski CF: Inhibition of long-term potentiation by NMDA-mediatcd nitric oxide release, Science 1992:257:1273-1276.
6. Xie QW, Cho HG, Calavcay J, Mumford RA, Swiderek KM, Lee TD, Ding A, Troso T, Nathan C: Cloning and characterization of inducible nitric oxide synthase from mouse macrophages, Science 1992:256:225-228.
7. Marietta MA: Nitric oxide synthase structure and mechanism, J Biol Chem 1993;268: 12231-12234.
8. Wolff DJ, Datto GA, Samatovicz RA, Temp-sick RA: Calmodulin-dependent nitric oxide synthase, J Biol Chem 1993:268:9425-9429.
9. Ogura T, Yokoyama T, Fujisawa H, Kurashi-ma Y, Esumi H: Structural diversity of neuronal nitric oxide synthase mRNA in the nervous system, Biochem Biophys Res Commun 1993: 193:1014-1022.
10. Schmidt HHHW, Pollock S, Nakane M, Gorsky LD, Forstermann U, Murad F: Purification of a soluble isoform of guanylyl cyclase-activat-ing-factor synthase, Proc Natl Acad Sci USA 1991;88:365-369.
11. Okada D: Two pathways of cyclic GMP production through glutamate receptor-mediated nitric oxide synthesis, J Neurochem 1992:59: 1203-1210.
12. Garthwaite JG, Charles SL, Chcss-Williams R: Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain, Nature 1988:336:385-388.
13. Morris RRGM, Anderson E, Lynnch GS, Baundry M: Selective impairment of learning and blockade of long-term potentiation by a N-methyl-D-aspartate receptor antagonist, AP5, Nature 1986:319:774-776.
14. Kim JS, Komhuber FIH, Schniid-Burgk W, Holzmullar B: Low cerebrospinal fluid glutamate in schizophrenia patients and a new hypothesis on schizophrenia, Ncurosci Lett 1980; 20:379-382.
15. Feelish M, Noack F.A: Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase, Eur J Pharmacol 1987:139:19-30.
16. Koyama T, Ishikanc T: Mechanism of action of antideprcssanl treatments, Clin Psychiatry (Seishin Igaku) 1994;36:17-21.
17. Hu J, Lee J, El-Fakahany EE: Inhibition of neuronal nitric oxide synthase by antipsychotic drugs, Psychopharmacology 1994:114:161-166.