Intestinal intraepithelial lymphocytes: Identification of an inhibitory subpopulation

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 123-127

  Teitelbaum, Daniel H ^a   Reyes, Brian C ^a   Merion, Robert M ^b   Mosley, R Lee ^b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN;

ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; INTESTINE EPITHELIUM CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MIXED LYMPHOCYTE CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL;

EID: 0029886985     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0234     Document Type: Conference Paper

References (26)

1. Trejdosiewicz, L. Intestinal intraepithelial lymphocytes and lymphoepithelial interaction in the human gastrointestinal mucosa. Immunol. Lett. 32: 13-20, 1992.
2. Guy-Grand, D., and Vassalli, P. Gut intraepithelial T lymphocytes. Curr. Opin. Immunol. 5(2): 247-52, 1993.
3. Mowat, A. M., MacKenzie, S., Baca, M. E., Felstein, M. V., and Parrott, D. M. Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli. Immunology 58(4): 627-34, 1986.
4. Lefrancois, L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147(6): 1746-51, 1991.
5. Mowat, A. M. Human intraepithelial lymphocytes. Springer Semin. Immunopathol. 12(2-3): 165-90, 1990.
6. Brandtzaeg, P., Halstensen, T. S., Kett, K., et al. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology 97(6): 1562-84, 1989.
7. Teitelbaum, D., Neideck, B., Lee, J., and Merion, R. Inhibitory activity of intesinal intraepithelial lymphocytes. Surgery 118: 378-384, 1995.
8. Mosley, R. L., and Klein, J. R. A rapid method for isolating murine intestine intraepithelial lymphocytes with high yield and purity. J. Immunol. Methods 156(1): 19-26, 1992.
9. Shapiro, H. Practical Flow Cytometry (2nd ed.). New York: Alan R. Liss, Inc., 1988.
10. Teitelbaum, D., Narasimhan, A., Chenault, R., and Merion, R. Lymphocyte immunologic interactions in intestinal transplantation. Transplant. Proc. 26(3): 1525-1526, 1994.
11. Turka, L., Ledbetter, J., Lee, K., June, C., and Thompson, C. CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD8+ mature thymocytes. J. Immunol. 144: 1646-1653, 1990.
12. Klein, J., and Mosley, R. Phenotypic and cytotoxic characteristics of intraepithelial lymphocytes. In H. Kiyono and J. McGhee (Eds.), Advances in Host Defense Mechanisms, vol. 9, pp. 33-60. New York: Raven Press, 1994.
13. Takimoto, H., Nakamura, T., Takeuchi, M., et al. Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats. Eur. J. Immunol. 22(1): 159-64, 1992.
14. Mosley, R. L., and Klein, J. R. Repopulation kinetics of intestinal intraepithelial lymphocytes in murine bone marrow radiation chimeras. Transplantation 53(4): 868-74, 1992.
15. Rocha, B., Vassalli, P., and Guy-Grand, D. Thymic and extrathymic origins of the gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 180: 681-686, 1994.
16. Fangmann, J., Schwinzer, R., Hedrich, H. J., and Wonigeit, K. Demonstration of RT6 expression on a CD3-population of intestinal intraepithelial lymphocytes of athymic nude rats. Transplant. Proc. 25(5): 2789-90, 1993.
17. Trejdosiewicz, L. K. What is the role of human intestinal intraepithelial lymphocytes? [editorial; comment]. Clin. Exp. Immunol. 94(3): 395-7, 1993.
18. Ebert, E. C. Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. Gastroenterology 97(6): 1372-81, 1989.
19. Hoang, P., Dalton, H., and Jewell, D. Human colonic intraepithelial lymphocytes are suppressor cells. Clin. Exp. Immunol. 82: 81-5, 1991.
20. Ebert, E. Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities. Clin. Exp. Immunol. 82: 81-85, 1990.
21. Dalton, H. R., Dipaolo, M. C., Sachdev, G. K., Crotty, B., Hoang, P., and Jewell, D. P. Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens. Clin. Exp. Immunol. 93(1): 97-102, 1993.
22. Pang, G., Clancy, R., and Saunders, H. Dual mechanisms of inhibition of the immune response by enterocytes isolated from the rat small intestine. Immunol. Cell Biol. 68(6): 387-96, 1990.
23. Poussier, P., Edouard, P., Lee, C., Binnie, M., and Julius, M. Thymus-independent development and negative selection of T cells expressing T cell receptor αβ in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes. J. Exp. Med. 176: 187-199, 1992.
24. Dorf, M., Kuchroo, V., and Collins, M. Suppresor T cells: some answers but more questions. Immunol. Today 13(7): 241-243, 1992.
25. Koide, J., and Engelman, E. Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones. J. Immunol. 144: 32-40, 1990.
26. Lombardi, G., Sidhu, S., Batchelor, R., and Lechler, R. Anergic T cells as suppressor cells in vitro. Science 264: 1587-1589, 1994.