Local intestinal immune responses to infections with Trichinella spiralis: Real-time, continuous assay of cytokines in the intestinal (afferent) and efferent thoracic duct lymph of rats

Journal of Immunology

Volumn 156, Issue 11, 1996, Pages 4328-4337

  Ramaswamy, Kalyanasundanam ^a,b   Negrao Correa, Deborah ^a   Bell, Robin ^a  

^a Cornell University ^*  (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HELMINTHIASIS; IMMUNE RESPONSE; INTESTINE INFECTION; LYMPH LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THORACIC DUCT; TRICHINELLA SPIRALIS;

ANIMALS; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; IMMUNOGLOBULIN E; IMMUNOTHERAPY, ADOPTIVE; INTERFERON TYPE II; INTERLEUKIN-4; INTERLEUKIN-5; INTESTINES; LYMPH; MALE; RATS; TRICHINELLA SPIRALIS; TRICHINOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029886740     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. + T-cell subsets in the regulation of parasite immunity and disease. Immunol. Rev. 112:161.
2. Bottomly, K. 1988. A functional dichotomy in CD4 T lymphocytes. Immunol. Today 9:274.
3. Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
4. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151.
5. + thoracic duct cells in rats: secretion of IL-4 alone does not determine protective capacity. Parasite Immunol. 16:435.
6. Urban, J. F., K. B. Madden, A. Svetic, A. Cheever, P. P. Trotta, W. C. Gause, I. D. Katona, and F. Finkelman. 1992. The importance of Th2 cytokines in protective immunity to nematodes. Immunol. Rev. 12:205.
7. Pond, L., D. L. Wassom, and C. E. Hayes. 1992. Influence of resistant and susceptible genotype, IL-1 and lymphoid organ on Trichinella spiralis-induced cytokine secretion. J. Immunol. 149:957.
8. Grencis, R. K., L. Hultner, and K. J. Else. 1991. Host protective immunity to Trichinella spiralis: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology 74:329.
9. Bell, R. G., M. Korenaga, and C. H. Wang. 1987. Characterization of a cell population in thoracic duct lymph that adoptively transfers rejection of adult Trichinella spiralis to normal rats. Immunology 61:221.
10. - T helper cells that are generated in the intestine. Immunology 66:588.
11. Taverne, J. 1994. Transgenic mice and the study of cytokine function in infection. Parasitol. Today 10:258.
12. Coffman, R. L., B-W. Seymour, S. Hudak, J. Jackson, and D. Rennick. 1989. Antibody to interleukin 5 inhibits helminth induced eosinophilia in mice. Science 245:308.
13. Else, K. J., L. Hultner, and R. K. Grencis. 1992. Modulation of cytokine production and response phenotypes in murine trichuriasis. Parasite Immunol. 14: 441.
14. Hay, E. D. 1981. Cell biology of extracellular matrix. Plenum Press, New York, p. 262.
15. Steer, H. W. 1981. Study of acute localized inflammation of the gastrointestinal tract: the effluent lymph. Gut 22:827.
16. - cells requires MHC class II compatibility. J. Immunol. 145:1021.
17. + cells. Immunology 71:166.
18. Bell, R. G., and T. Issekutz. 1993. Expression of a protective intestinal immune response can be inhibited at 3 distinct sites by treatment with anti-α4 integrin. J. Immunol. 151:4790.
19. Bell, R. G., and D. D. McGregor. 1979. Trichinella spiralis: expression of rapid expulsion in rats exposed to an abbreviated enteral infection. Exp. Parasitol. 48:42.
20. Bell, R. G., and D. D. McGregor. 1980. Requirement for two discrete stimuli for the induction of the intestinal rapid expulsion response against Trichinella spiralis in rats. Infect. Immun. 29:186.
21. Ahmad, A., C. H. Wang, and R. G. Bell. 1991. A role for IgE in intestinal immunity: expression of rapid expulsion of Trichinella spiralis in rats transfused with IgE and thoracic duct lymphocytes. J. Immunol. 146:3563.
22. Brideau, R. J., P. B. Carter, W. R. McMaster, D. W. Mason, and A. F. Williams. 1980. Two subsets of rat T lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 10:609.
23. Spickett, G. P., M. R. Brandon, D. W. Mason, A. F. Williams, and G. R. Woollett. 1983. MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular form of the leukocyte-common antigen. J. Exp. Med. 158:795.
24. Bergstedt-Lindqvist, S., H. Moon, U. Persson, G. Moller, C. Heusser, and E. Severinson. 1988. Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG1 and IgE. Eur. J. Immunol. 18:1073.
25. Zsebo, K. M., J. Wypych, I. K. McNiece, H. S. Lu, K. A. Smith, S. B. Karkare, R. K. Sachdev, V. N. Yuschenkoff, N. C. Birkett, L. R. Williams, V. N. Satyagal, W. Tung, R. A. Bosselman, E. A. Mendiaz, and K. E. Langley. 1990. Identification, purification and biological characterization of haematopoietic stem cell factor from buffalo rat liver-conditioned medium. Cell 63:195.
26. van der Meide, P. H., M. Dubbed, K. Vijverberg, T. Kos, and H. Schellekens. 1986. The purification and characterization of rat gamma interferon by use of two monoclonal antibodies. J. Gen. Virol. 67:1059.
27. Mosmann, T. 1983. Rapid calorimetric assay for cellular growth and survival: application to proliferation and cytokine assays. J. Immunol. Methods 65:55.
28. Deitch, E. A., D. Xu, L. Franko, A. Ayala, and I. H. Chaudry. 1994. Evidence favoring the role of the gut as a cytokine-generating organ in rats subjected to hemorrhagic shock. Shock 1:141.
29. Punnonen, J., G. Aversa, B. G. Cocks, and J. E. de Vries. 1994. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells. Allergy 49:576.
30. Grotz, M. R. W., J. Y. Ding, W. D. Guo, Q. H. Huang, and E. A. Deitch. 1995. Comparison of plasma cytokine levels in rats subjected to superior mesenteric artery occlusion or hemorrhagic shock. Shock 3:1073.
31. Vilcek, J., and I. C. Oliveira. 1994. Recent progress in the elucidation of interferon-gamma actions- molecular biology and biological functions. Int. Arch. Allergy Appl. Immunol. 104:311.
32. Pond, L., D. L. Wassom, and C. E. Hayes. 1989. Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection. J. Immunol. 143:4232.
33. Grencis, R. K., and D. Wakelin. 1982. Short lived, dividing cells mediate adoptive transfer of immunity to Trichinella spiralis in mice. I. Availability of cells in primary and secondary infections in relation to cellular changes in the mesenteric lymph node. Immunology 46:443.
34. Svetic, A., K. B. Madden, X. D. Zhou, P. Lu, I. M. Katona, F. D. Finkelman, J. F. Urban, and W. C. Gause. 1993. A primary intestinal helminthic infection rapidly induces a gut-associated elevation of Th2-associated cytokines and IL-3. J. Immunol. 150:3434.
35. Urban, J. F., Jr., I. L. Katona, W. E. Paul, and F. D. Finkelman. 1991. Interleukin-4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc. Natl. Acad. Sci. USA 88:5513.
36. Behnke, J. M., F. N. Wahid, R. K. Grencis, K. J. Else, A. W. Smith, and P. K. Goyal. 1993. Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms. Parasite Immunol. 15:415.