Growth regulatory proteins that repress differentiation markers in melanocytes also downregulate the transcription factor Microphthalmia

Journal of Investigative Dermatology

Volumn 106, Issue 6, 1996, Pages 1266-1272

  Halaban, Ruth ^a   Böhm, Markus ^a   Dotto, Paolo ^b   Moellmann, Gisela ^a   Cheng, Elaine ^a   Zhang, Yuhua ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

basic FGF; dominantly acting oncogenes; E1A; FGF2; p300

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; ENDOGENOUS COMPOUND; MONOPHENOL MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; MELANOCYTE; MELANOMA; MOUSE; NONHUMAN; ONCOGENE NEU; ONCOGENE RAS; PIGMENT DISORDER; PRIORITY JOURNAL;

EID: 0029886566     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12348972     Document Type: Article

References (44)

1. Arany Z, Newsome D, Oldread E, Livingston DM, Eckner R: A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature 374:81-84, 1995
2. Arias S: Mutations of PAX3 unlikely in Waardenburg syndrome type 2. Nature Genet 5:8, 1993 (lett.)
3. Baldwin CT, Lipsky NR, Hoth CF, Cohen T, Mamuya W, Milunsky A: Mutations in PAX3 associated with Waardenburg syndrome type I. Hum Mutat 3:205-211, 1994
4. Bentley NJ, Eisen T, Goding CR: Melanocyte-specific expression of the human tyrosinase promoter: activation by the microphthalmia gene product and role of the initiator. Mol Cell Biol 14:7996-8006, 1994
5. 133 kinase in human melanocytes. Cell Growth & Differ 6:241-302, 1995
6. Boulukos KE, Ziff EB: Adenovirus 5 E1A proteins disrupt the neuronal phenotype and growth factor responsiveness of PC12 cells by a conserved region 1-dependent mechanism. Oncogene 8:237-248, 1993
7. Bradl M, Klein-Szanto A, Porter S, Mintz B: Malignant melanoma in transgenic mice. Proc Natl Acad Sci USA 88:164-168, 1991
8. Chakraborty AK, Platt JT, Kim KK, Kwon BS, Bennet DC, Pawelek JM: Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the Pmel 17 silver locus protein. Eur J Biochem 236:180-188, 1996
9. Cobrinik D, Whyte P, Peeper DS, Jacks T, Weinberg RA: Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev 7:2392-2404, 1993
10. Delezoide AL, Vekemans M: Waardenburg syndrome in man and splotch mutants in the mouse: a paradigm of the usefulness of linkage and synteny homologies in mouse and man for the genetic analysis of human congenital malformations. Biomed Pharmacother 48:335-339, 1994
11. Dooley TP, Wilson RE, Jones NC, Hart IR: Polyoma middle T abrogates TPA requirement of murine melanocytes and induces malignant melanoma. Oncogene 3:531-535, 1988
12. Dotto GP, Moellmann G, Ghosh S, Edwards M, Halaban R: Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. J Cell Biol 109:3115-3128, 1989
13. Dotto GP, Weinberg RA, Ariza A: Malignant transformation of mouse primary keratinocytes by HaSV and its modulation by surrounding normal cells. Proc Natl Acad Sci USA 85:6389-6393, 1988
14. Dyson N: pRB, p107 and the regulation of the E2F transcription factor. J Cell Sci 18(suppl):81-7, 1994 (review)
15. Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB, Livingston DM: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev 8:869-884, 1994
16. Fattaey AR, Harlow E, Helin K: Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol 13:7267-7277, 1993
17. Halaban R, Pomerantz SH, Marshall S, Lambert DT, Lerner AB: Regulation of tyrosinase in human melanocytes grown in culture. J Cell Biol 97:480-488, 1983
18. Harlow E, Whyte P, Franza B Jr, Schley C: Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol 6:1579-1589, 1986
19. Hemesath TJ, Steingrimsson E, McGill G, Hansen MJ, Vaught J, Hodgkinson CA, Arnheiter H, Copeland NG, Jenkins NA, Fisher DE: Microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev 8:2770-2780, 1994
20. Hoth CF, Milunsky A, Lipsky N, Sheffer R, Clarren SK, Baldwin CT: Mutations in the paired domain of the human PAX3 gene cause Klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I). Am J Hum Genet 52:455-462, 1993
21. Jambrosic J, Mancianti ML, Ricciardi R, Sela B-A, Koprowski H, Herlyn M: Transformation of normal human melanocytes and non-malignant nevus cells by adenovirus 12-SV40 hybrid virus. Int J Cancer 44:1117-1123, 1989
22. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR: E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 69:2491-2500, 1995
23. Kwon BS, Kim KK, Halaban R, Pickard RT: Characterization of mouse pmel 17 gene and silver locus. Pigm Cell Res 7:394-397, 1994
24. Larue L, Dougherty N, Bradl M, Mintz B: Melanocyte culture lines from Tyr-SV40E transgenic mice: models for the molecular genetic evolution of malignant melanoma. Oncogene 8:523-531, 1993
25. Lee ZH, Hou L, Moellmann G, Kuklinska E, Antol K, Fraser M, Halaban R, Kwon BS: Characterization and subcellular localization of human Pmel 17/silver, a 100-kDa (pre)melanosomal membrane protein associated with DHICA converting activity. J Invest Dermatol 106:605-610, 1996
26. Li Y, Graham C, Lacy S, Duncan AM, Whyte P: The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev 7:2366-2377, 1993
27. Lowings P, Yavuzer U, Goding CR: Positive and negative elements regulate a melanocyte-specific promoter. Mol Cell Biol 12:3653-3662, 1992
28. Lundblad JR, Kwok RP, Laurance ME, Harter ML, Goodman RH: Adenoviral E1A-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374:85-88, 1995
29. Missero C, Filvaroff E, Dotto GP: Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins. Proc Natl Acad Sci USA 88:3489-3493, 1991
30. Nevins JR: Disruption of cell-cycle control by viral oncoproteins. Biochem Soc Trans 21:935-938, 1993 (review)
31. Orlow SJ, Hearing VJ, Sakai C, Urabe K, Zhou BK, Silvers WK, Mintz B: Changes in expression of putative antigens encoded by pigment genes in mouse melanomas at different stages of malignant progression. Proc Natl Acad Sci USA 92:10152-10156, 1995
32. Peeper DS, Zantema A: Adenovirus-E1A proteins transform cells by sequestering regulatory proteins. Mol Biol Rep 17:197-207, 1993 (review)
33. Pierpont JW, Doolan LD, Amann K, Snead GR, Erickson RP: A single base pair substitution within the paired box of PAX3 in an individual with Waardenburg syndrome type 1 (WS1). Hum Mutat 4:227-228, 1994
34. Rosemblat S, Durham-Pierre D, Gardner JM, Nakatsu Y, Brilliant MH, Orlow SJ: Identification of a melanosomal membrane protein encoded by the pink-eyed dilution (type II oculocutaneous albinism) gene. Proc Natl Acad Sci USA 91:12071-12075, 1994
35. Shibahara S, Taguchi H, Muller RM, Shibata K, Cohen T, Tomira Y, Tagami H: Structural organization of the pigment cell-specific gene located at the brown locus in mouse: its promoter activity and alternatively spliced transcript. J Biol Chem 266:15895-15901, 1991
36. Shin EK, Shin A, Paulding C, Schaffhausen B, Yee AS: Multiple change in E2F function and regulation occur upon muscle differentiation. Mol Cell Biol 15:2252-2262, 1995
37. Tamura A, Halaban R, Moellmann G, Cowan JM, Lerner MR, Lerner AB: Normal murine melanocytes in culture. In Vitro Cell Dev Biol 23:519-522, 1987
38. Fassabehji M, Read AP, Newton VE, Patton M, Gruss P, Harris R, Strachan T: Mutations in the PAX3 gene causing Waardenburg syndrome type 1 and type 2. Nature Genet 3:26-30, 1993
39. Tsai LH, Harlow E, Meyerson M: Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature 353:174-177, 1991
40. Tsukamoto K, Jackson I, Hearing V: DOPAchrome tautomerase: identification of its gene and catalytic activity. EMBO J 11:519-526, 1992
41. White E: Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus. Proc Soc Exp Biol Med 204:30-39, 1993 (review)
42. Wilson RE, Dooley TP, Hart IR: Induction of tumorigenicity and lack of in vitro growth requirement for 12-O-tetradecamoylphorbol-13-acetate by transfection of murine melanocytes with v-Ha-ras. Cancer Res 49:711-716, 1989
43. Yasumoto KI, Yokoyama K, Shibata K, Tomita Y, Shibahara S: Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol 14:8058-8070, 1994
44. Yavuzer U, Keenan E, Towings P, Vachtenhenn J, Currie G, Goding CR: The microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription. Oncogene 10:123-134, 1995