Pancreatin preparations used in the treatment of cystic fibrosis - Lipase content and in vitro release

Alimentary Pharmacology and Therapeutics

Volumn 10, Issue 3, 1996, Pages 433-440

  Walters, M P ^a,b   Littlewood, J M ^a  

^a St James' Seacroft Univ Hospitals   (United Kingdom)

^b St Jame's and Seacroft University Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREON 25000; KREON; NUTRIZYM GR; PANCREAS ENZYME; PANCREASE HL; PANCREATIN; PANCRELIPASE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CYSTIC FIBROSIS; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; PRIORITY JOURNAL; SIMULATION;

BILE ACIDS AND SALTS; BODY FLUIDS; BUFFERS; CYSTIC FIBROSIS; DUODENUM; GASTROINTESTINAL AGENTS; HYDROGEN-ION CONCENTRATION; LIPASE; PANCREATIN; SOLUBILITY; TRYPSIN INHIBITORS;

EID: 0029885908     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-0673.1996.00433.x     Document Type: Article

References (20)

1. Shepherd RW, Holt TL, Wall C, et al. Nutrition in cystic fibrosis. Nutr Rev 1991; 4: 51-7.
2. Stead RJ, Skypala I, Hudson ME. Enteric coated microspheres of pancreatin in the treatment of cystic fibrosis: comparison with a standard enteric coated preparation. Thorax 1987; 42: 533-7.
3. Beverley DW, Kelleher J, MacDonald A, et al. Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis Child 1987; 62: 564-8.
4. Bowler IM, Wolle SP, Owens HM, et al. A double-blind lipase for lipase comparison of a high lipase and standard pancreatic enzyme preparation in cystic fibrosis. Arch Dis Child 1993; 68: 227-30.
5. Morrison G, Morrison JM, Redmond AO, et Al. Comparison between a standard pancreatic supplement and a high enzyme preparation in cystic fibrosis. Aliment Pharmacol Ther 1992; 6: 549-55.
6. Smyth RL, van Velzen D, Smyth AR, Lloyd DA, Heaf DP. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994; 343: 85-6.
7. Deasy P. Microencapsulation and related drug processes. In: Drugs and the Pharmaceutical Sciences. Vol. 20. New York: Dekker Press, 1984: 21-59.
8. Zentler-Munro PL, Northfield TC. Review article: pancreatic enzyme replacement, applied physiology and pharmacology. Aliment Pharmacol Ther 1987; 1: 575-91.
9. Youngberg CA, Berardi RR, Howatt WF. et al. Comparison of gastrointestinal pH in cystic fibrosis and healthy subjects. Dig Dis Sci 1987; 32: 472-80.
10. Gilbert J, Kelleher J, Littlewood JM, Evans DF. Ileal pH in cystic flbrosis. Scand J Gastroenterol 1988; 23: 132-4.
11. Robinson PJ, Smith AL, Sly PD. Duodenal pH in cystic fibrosis and its relationship to fat absorption. Dig Dis Sci 1990; 35: 1299-1304.
12. Walters MP. Cystic fibrosis: studies in faecal bile acid loss and the characterisation of pancreatic enzymes used in treatment. Thesis. Institute of Biomedical Science, 1994.
13. Otte M, Gutowski HD, Mackenroth T. In vitro testing of pancreatic enzyme preparations. In: Lankisch PG, ed. Pancreatic Enzymes in Health and Disease. New York: Springer, 1991: 65-70.
14. Burrell LM, Boyd EJ, Wormsley KG. Is the fluorescein dilaurate test suitable for monitoring the effectiveness of pancreatic enzyme replacement therapy? Scand J Clin Lab Invest 1991; 51: 675-80.
15. Adler G, Mundlos S, Kuhnelt P, Dreyer E. New methods for assessment of enzyme activity: do they help to optimize enzyme treatment? Digestion 1993; 54 (Suppl. 2): 3-9.
16. Littlewood JM, Kelleher J, Walters MP, Johnson AW. In vivo and in vitro studies of microsphere pancreatic supplements. J Pediatr Gastroenterol Nutr 1988; 7: S22.
17. Whitehead AM. Study to compare enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations. Pharm Weekbl (Sci) Ed. 1988; 10: 12-6.
18. Atkinson SN. A comparative study of the enzyme activity, acid resistance and dissolution characteristics of four enteric coated microsphere preparations of pancreatin. Eur J Clin Res 1991; 1: 37-45.
19. Thiruvengadam R, Di Mango EP. Inactivation of human lipase by proteases. Am J Physiol 1988; 255: G476-81.
20. Wrong OM, Edmonds CJ, Chadwick VS. The lipids. In: The Large Intestine. Lancaster: MTP Press, 1981: 131-2.